Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
| ▸ | GSK3A | P49840 | 1/20 | 0.40 |
| ▸ | GSK3B | P49841 | 1/20 | 0.40 |
| ▸ | NCOA1 | Q15788 | 1/20 | 0.40 |
| ▸ | NCOA3 | Q9Y6Q9 | 1/20 | 0.40 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.39 |
| ▸ | RAB9A | P51151 | 2/20 | 0.38 |
| ▸ | USP2 | O75604 | 1/20 | 0.38 |
| ▸ | LTA4H | P09960 | 1/20 | 0.38 |
| ▸ | CYP11B1 | P15538 | 3/20 | 0.38 |
| ▸ | CYP19A1 | P11511 | 2/20 | 0.38 |
| ▸ | CYP11B2 | P19099 | 2/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | GRK2 | P25098 | 1/20 | 0.37 |
| ▸ | IDO1 | P14902 | 1/20 | 0.37 |
| ▸ | LOXL2 | Q9Y4K0 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27575289 | 0.92 | ALDH1A1 (0.40) | L3MBTL1SMN1; SMN2ALDH1A1HTTGSK3A | |
| SCHEMBL8202649 | 0.85 | CYP3A4 (0.48) | SMN1; SMN2ALDH1A1RAB9ACYP11B1CYP19A1 | |
| SCHEMBL8364378 | 0.85 | TRPA1 (0.45) | TRPA1RAB9AKMT2AIDO1LOXL2 | |
| SCHEMBL8210813 | 0.79 | NFE2L2 (0.52) | L3MBTL1SMN1; SMN2ALDH1A1TRPA1MEN1 | |
| SCHEMBL6456118 | 0.79 | G6PC1 (0.49) | SMN1; SMN2ALDH1A1HTTCYP19A1CYP11B2 | |
| SCHEMBL16178490 | 0.76 | MAPT (0.49) | SMN1; SMN2ALDH1A1HTTTRPA1RAB9A | |
| SCHEMBL3274573 | 0.76 | NFE2L2 (0.57) | SMN1; SMN2ALDH1A1HTTTRPA1RAB9A | |
| SCHEMBL5966235 | 0.75 | CYP1A2 (0.46) | SMN1; SMN2ALDH1A1HTTCYP11B1CYP19A1 | |
| SCHEMBL654153 | 0.75 | NFE2L2 (0.52) | L3MBTL1SMN1; SMN2ALDH1A1TRPA1MEN1 | |
| SCHEMBL6632469 | 0.73 | MAPT (0.62) | L3MBTL1SMN1; SMN2ALDH1A1RAB9ACYP19A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7169787-B2 | 7-azaindoles, use thereof as phosphodiesterase 4 inhibitors and method for producing the same | ELBION AG (DE) | 2007-01-30 | — | — | US | disclosed |
| CN-1247576-C | Novel 7-azaindoles, their use as inhibitors of phosphodiesterase 4 and process for their preparation | ELBION AG (DE) | 2006-03-29 | — | — | CN | disclosed |
| CN-1484644-A | Novel 7-azaindoles, their use as inhibitors of phosphodiesterase 4 and process for their preparation | �����ɷ� | 2004-03-24 | — | — | CN | disclosed |