Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 3/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.39 |
| ▸ | PKM | P14618 | 1/20 | 0.39 |
| ▸ | CNR1 | P21554 | 1/20 | 0.38 |
| ▸ | CNR2 | P34972 | 1/20 | 0.38 |
| ▸ | ELANE | P08246 | 2/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.37 |
| ▸ | SRC | P12931 | 1/20 | 0.36 |
| ▸ | HTT | P42858 | 2/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.35 |
| ▸ | TP53 | P04637 | 2/20 | 0.35 |
| ▸ | GAA | P10253 | 1/20 | 0.35 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.34 |
| ▸ | AKR1C2 | P52895 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5559414 | 0.90 | LMNA (0.40) | MAPTKMT2AELANEALDH1A1SRC | |
| SCHEMBL5800049 | 0.87 | KMT2A (0.37) | MAPTKMT2ASRCHTTKDM4E | |
| SCHEMBL5560264 | 0.86 | PTGS2 (0.35) | MAPTKMT2APKMELANEABCB11 | |
| SCHEMBL5559667 | 0.86 | PTGS2 (0.35) | MAPTABCB11SRCHTTKDM4E | |
| SCHEMBL6025282 | 0.84 | PTGS1 (0.47) | MAPTKMT2APKMCNR1CNR2 | |
| SCHEMBL5553811 | 0.84 | MAPT (0.40) | MAPTKMT2APKMALDH1A1SRC | |
| SCHEMBL5814619 | 0.81 | CNR1 (0.38) | MAPTKMT2APKMCNR1CNR2 | |
| SCHEMBL5822002 | 0.80 | CNR2 (0.58) | MAPTKMT2ACNR1CNR2ABCB11 | |
| SCHEMBL5558604 | 0.80 | SRC (0.47) | KMT2AALDH1A1SRCKDM4EHSD17B10 | |
| SCHEMBL5547116 | 0.79 | PTGS2 (0.43) | KMT2ACNR1CNR2ELANEALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1643961-A4 | COX-2 AND FAAH INHIBITORS | MICROBIA INC (US) | 2007-09-12 | — | — | EP | disclosed |
| EP-1643961-A2 | COX-2 AND FAAH INHIBITORS | Microbia, Inc. (US) | 2006-04-12 | — | — | EP | disclosed |
| WO-2005002525-A2 | COX-2 AND FAAH INHIBITORS | MICROBIA, INC. (US) | 2005-01-13 | — | — | WO | disclosed |