Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRM4 | Q14833 | 1/20 | 0.35 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.31 |
| ▸ | LMNA | P02545 | 1/20 | 0.31 |
| ▸ | TP53 | P04637 | 1/20 | 0.31 |
| ▸ | MAPT | P10636 | 1/20 | 0.31 |
| ▸ | HPGD | P15428 | 1/20 | 0.31 |
| ▸ | TSHR | P16473 | 1/20 | 0.31 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.31 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.31 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL156897 | 0.68 | POLB (0.47) | GRM4KDM4EALDH1A1LMNATP53 | |
| SCHEMBL69609 | 0.67 | NOTUM (0.39) | KDM4EMAPTHPGDTSHRHSD17B10 | |
| SCHEMBL6072194 | 0.67 | NOTUM (0.41) | GRM4KDM4EALDH1A1LMNATP53 | |
| SCHEMBL5759656 | 0.66 | ALDH1A1 (0.33) | ALDH1A1HPGDSMN1; SMN2HSD17B10 | |
| SCHEMBL16719635 | 0.65 | MAOA (0.39) | KDM4EALDH1A1LMNAMAPTHPGD | |
| SCHEMBL1907451 | 0.65 | SMN1; SMN2 (0.48) | GRM4FGFR1KDM4EALDH1A1LMNA | |
| SCHEMBL10417623 | 0.65 | HSD17B10 (0.35) | GRM4KDM4EALDH1A1LMNATP53 | |
| SCHEMBL4205737 | 0.65 | LMNA (0.37) | KDM4EALDH1A1LMNAMAPTHPGD | |
| SCHEMBL21129389 | 0.64 | GRM4 (0.50) | GRM4KDM4EALDH1A1LMNATP53 | |
| SCHEMBL19961716 | 0.63 | GRM4 (0.43) | GRM4KDM4EALDH1A1LMNATP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 465 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2908824-B1 | TRICYCLIC SUBSTITUTED THIADIAZINE DIOXIDE COMPOUNDS AS BACE INHIBITORS, COMPOSITIONS, AND THEIR USE | MERCK SHARP & DOHME (US) | 2018-05-02 | — | — | EP | claimed |
| EP-2908825-B1 | TRICYCLIC SUBSTITUTED THIADIAZINE DIOXIDE COMPOUNDS AS BACE INHIBITORS, COMPOSITIONS, AND THEIR USE | MERCK SHARP & DOHME (US) | 2018-04-18 | — | — | EP | claimed |
| EP-2672819-B1 | PESTICIDAL COMPOSITIONS AND PROCESSES RELATED THERETO | DOW AGROSCIENCES LLC (US) | 2017-11-29 | — | — | EP | claimed |
| EP-3194414-A1 | METHODS FOR THE PREPARATION OF DIASTEREOMERICALLY PURE PHOSPHORAMIDATE PRODRUGS | MEDIVIR AB (SE) | 2017-07-26 | — | — | EP | claimed |
| US-9422277-B2 | Tricyclic substituted thiadiazine dioxide compounds as BACE inhibitors, compositions and their use | MERCK SHARP & DOHME CORP. (US) | 2016-08-23 | — | — | US | claimed |
| US-9416129-B2 | Tricyclic substituted thiadiazine dioxide compounds as BACE inhibitors, compositions and their use | MERCK SHARP & DOHME CORP. (US) | 2016-08-16 | — | — | US | claimed |
| US-20160135464-A1 | PESTICIDAL COMPOSITIONS AND PROCESSES RELATED THERETO | DOW AGROSCIENCES LLC (US) | 2016-05-19 | — | — | US | claimed |
| EP-2694509-B1 | PYRROLO[2,3-D]PYRIMIDINE DERIVATIVES AS INHIBITORS OF TROPOMYOSIN-RELATED KINASES | PFIZER LTD (GB) | 2016-05-18 | — | — | EP | claimed |
| WO-2016041877-A1 | METHODS FOR THE PREPARATION OF DIASTEREOMERICALLY PURE PHOSPHORAMIDATE PRODRUGS | MEDIVIR AB (SE) | 2016-03-24 | — | — | WO | claimed |
| US-20150284379-A1 | TRICYCLIC SUBSTITUTED THIADIAZINE DIOXIDE COMPOUNDS AS BACE INHIBITORS, COMPOSITIONS AND THEIR USE | MERCK SHARP & DOHME CORP. (US) | 2015-10-08 | — | — | US | claimed |
| US-7271283-B2 | High refractive index, UV-curable monomers and coating compositions prepared therefrom | GENERAL ELECTRIC COMPANY (US) | 2007-09-18 | — | — | US | claimed |
| JP-2007517887-A | — | — | 2007-07-05 | — | — | JP | claimed |
| EP-1709047-A2 | AZABENZOFURAN SUBSTITUTED THIOUREAS AS INHIBITORS OF VIRAL REPLICATION | Achillion Pharmaceuticals, Inc. (US) | 2006-10-11 | — | — | EP | claimed |
| US-20060014836-A1 | Substituted aryl thioureas and related compounds; inhibitors of viral replication | CHEN DAWEI | 2006-01-19 | — | — | US | claimed |
| US-20050228013-A1 | Azabenzofuran substituted thioureas; inhibitors of viral replication | ACHILLION PHARMACEUTICALS, INC. | 2005-10-13 | — | — | US | claimed |
| EP-1562895-A1 | SUBSTITUTED ARYL ACYLTHIOUREAS AND RELATED COMPOUNDS; INHIBITORS OF VIRAL REPLICATION | Achillion Pharmaceuticals, Inc. (US) | 2005-08-17 | — | — | EP | claimed |
| WO-2005067900-A2 | AZABENZOFURAN SUBSTITUTED THIOUREAS AS INHIBITORS OF VIRAL REPLICATION | ACHILLION PHARMACEUTICALS, INC. (US) | 2005-07-28 | — | — | WO | claimed |
| US-20050049376-A1 | High refractive index, uv-curable monomers and coating compositions prepared therefrom | GENERAL ELECTRIC COMPANY | 2005-03-03 | — | — | US | claimed |
| US-20040138205-A1 | Substituted aryl thioureas and related compounds; inhibitors of viral replication | ACHILLION PHARMACEUTICALS, INC. | 2004-07-15 | — | — | US | claimed |
| WO-2004046095-A1 | SUBSTITUTED ARYL THIOUREAS AND RELATED COMPOUNDS; INHIBITORS OF VIRAL REPLICATION | ACHILLION PHARMACEUTICALS, INC. (US) | 2004-06-03 | — | — | WO | claimed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (6 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040138205-A1 | Substituted aryl thioureas and related compounds; inhibitors of viral replication | NAT1, PIGS, TPMT | GRM4 4770/4885FGFR1 1904/4885KDM4E 1098/4885 |
| US-20060014836-A1 | Substituted aryl thioureas and related compounds; inhibitors of viral replication | NAT1, PIGS, SLC10A1 | GRM4 4816/4885FGFR1 1947/4885KDM4E 1559/4885 |
| US-20160135464-A1 | PESTICIDAL COMPOSITIONS AND PROCESSES RELATED THERETO | CYP19A1, CYP1A1, AR | GRM4 1486/4885FGFR1 2877/4885KDM4E 3406/4885 |
| US-20050049376-A1 | High refractive index, uv-curable monomers and coating compositions prepared therefrom | MACF1, WASF2, THEM6 | GRM4 1048/4885FGFR1 2285/4885KDM4E 3417/4885 |
| US-20050228013-A1 | Azabenzofuran substituted thioureas; inhibitors of viral replication | NAT1, PIGS, ADORA1 | GRM4 4573/4885FGFR1 3160/4885KDM4E 626/4885 |
| US-20150284379-A1 | TRICYCLIC SUBSTITUTED THIADIAZINE DIOXIDE COMPOUNDS AS BACE INHIBITORS, COMPOSITIONS AND THEIR USE | BACE1, BACE2, APP | GRM4 3667/4885FGFR1 926/4885KDM4E 2120/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.