Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAOA | P21397 | 1/20 | 0.39 |
| ▸ | CHKA | P35790 | 1/20 | 0.35 |
| ▸ | BCHE | P06276 | 1/20 | 0.34 |
| ▸ | FLT3 | P36888 | 1/20 | 0.33 |
| ▸ | GSK3B | P49841 | 1/20 | 0.33 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.32 |
| ▸ | NCF1 | P14598 | 1/20 | 0.32 |
| ▸ | PLD1 | Q13393 | 1/20 | 0.32 |
| ▸ | NOTUM | Q6P988 | 2/20 | 0.31 |
| ▸ | LMNA | P02545 | 1/20 | 0.31 |
| ▸ | MAPT | P10636 | 1/20 | 0.31 |
| ▸ | EP300 | Q09472 | 1/20 | 0.31 |
| ▸ | KAT2B | Q92831 | 1/20 | 0.31 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.30 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.30 |
| ▸ | HPGD | P15428 | 1/20 | 0.30 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.30 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.30 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL344002 | 0.78 | NOTUM (0.48) | FLT3GSK3BNOTUMLMNAMAPT | |
| SCHEMBL6650803 | 0.77 | MAPT (0.42) | LMNAMAPTKDM4EALDH1A1HPGD | |
| SCHEMBL7229166 | 0.77 | NOTUM (0.47) | FLT3NOTUMLMNAMAPTKDM4E | |
| SCHEMBL1896258 | 0.77 | NOTUM (0.47) | FLT3NOTUMLMNAMAPTKDM4E | |
| SCHEMBL17710270 | 0.70 | MGLL (0.42) | MAOAMAPTKDM4EALDH1A1SMN1; SMN2 | |
| SCHEMBL2753713 | 0.69 | RXRA (0.36) | LMNAMAPTKAT2B | |
| SCHEMBL28011574 | 0.69 | RXRA (0.40) | MAOAMAPTKDM4EALDH1A1L3MBTL1 | |
| SCHEMBL6683072 | 0.68 | HTR1A (0.37) | — | |
| SCHEMBL2751668 | 0.64 | AR (0.41) | NOTUMALDH1A1 | |
| SCHEMBL4473412 | 0.64 | NOTUM (0.63) | CHKANOTUMLMNAMAPTKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9206175-B2 | Substituted 6,6-fused nitrogenous heterocyclic compounds and uses thereof | GENENTECH, INC. (US) | 2015-12-08 | — | — | US | claimed |
| CN-105408322-B | Terazololine-one compound and application thereof | 住友化学株式会社 | 2019-04-19 | — | — | CN | disclosed |
| EP-3029038-B1 | TETRAZOLINONE COMPOUND AND USE THEREOF | SUMITOMO CHEMICAL CO (JP) | 2019-03-27 | — | — | EP | disclosed |
| US-9781933-B2 | Tetrazolinone compound and use thereof | SUMITOMO CHEMICAL COMPANY, LIMITED (JP) | 2017-10-10 | — | — | US | disclosed |
| EP-3068758-A1 | EBNA1 INHIBITORS AND THEIR METHOD OF USE | The Wistar Institute Of Anatomy And Biology (US) | 2016-09-21 | — | — | EP | disclosed |
| US-20160174558-A1 | TETRAZOLINONE COMPOUND AND USE THEREOF | SUMITOMO CHEMICAL COMPANY, LIMITED (JP) | 2016-06-23 | — | — | US | disclosed |
| EP-3029038-A1 | TETRAZOLINONE COMPOUND AND USE THEREOF | Sumitomo Chemical Company Limited (JP) | 2016-06-08 | — | — | EP | disclosed |
| CN-105408322-A | Tetrazolinone compound and use thereof | SUMITOMO CHEMICAL CO | 2016-03-16 | — | — | CN | disclosed |
| WO-2015073864-A1 | EBNA1 INHIBITORS AND THEIR METHOD OF USE | THE WISAR INSTITUTE OF ANATOMY AND BIOLOGY (US) | 2015-05-21 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20160174558-A1 | TETRAZOLINONE COMPOUND AND USE THEREOF | MT-CO1, KCNA5, MT-CO2 | MAOA 961/4885CHKA 3934/4885BCHE 3248/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.