Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | TSHR | P16473 | 1/20 | 0.42 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.39 |
| ▸ | ADORA3 | P0DMS8 | 2/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | HSD17B1 | P14061 | 1/20 | 0.39 |
| ▸ | HSD17B2 | P37059 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.39 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.39 |
| ▸ | IDO1 | P14902 | 1/20 | 0.39 |
| ▸ | PDE5A | O76074 | 1/20 | 0.38 |
| ▸ | PDE4A | P27815 | 1/20 | 0.38 |
| ▸ | PDE1A | P54750 | 1/20 | 0.38 |
| ▸ | PDE1B | Q01064 | 1/20 | 0.38 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.38 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.38 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10692521 | 0.81 | KDM4E (0.40) | ALDH1A1KMT2AMEN1TSHRMAPT | |
| SCHEMBL7771748 | 0.76 | HSD17B1 (0.46) | ALDH1A1KMT2AMEN1TSHRMAPT | |
| SCHEMBL1355596 | 0.76 | ALDH1A1 (0.45) | ALDH1A1KMT2AMEN1TSHRMAPT | |
| SCHEMBL6774791 | 0.74 | BRD4 (0.55) | ALDH1A1KMT2AMEN1TSHRADORA3 | |
| SCHEMBL76231 | 0.72 | ACHE (0.48) | ALDH1A1KMT2AMEN1MAPTKDM4E | |
| SCHEMBL7140477 | 0.72 | TUBB4A (0.46) | ALDH1A1KMT2AMEN1TSHRMAPT | |
| SCHEMBL11456734 | 0.71 | KDM4E (0.49) | ALDH1A1KMT2ATSHRMAPTKDM4E | |
| SCHEMBL7959158 | 0.71 | PDE5A (0.45) | ALDH1A1KMT2AMEN1TSHRABCB1 | |
| SCHEMBL26850914 | 0.71 | ABCB1 (0.47) | ALDH1A1KMT2AMEN1TSHRABCB1 | |
| SCHEMBL8531955 | 0.71 | MEN1 (0.48) | ALDH1A1KMT2AMEN1TSHRABCB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1673092-B1 | HETEROCYCLE-SUBSTITUTED PTERIDINE DERIVATIVES AND THEIR USE IN THERAPY | 4 AZA IP NV (BE) | 2007-08-15 | — | — | EP | disclosed |
| EP-1673092-A1 | HETEROCYCLE-SUBSTITUTED PTERIDINE DERIVATIVES AND THEIR USE IN THERAPY | 4 AZA Bioscience nv (BE) | 2006-06-28 | — | — | EP | disclosed |
| WO-2005039587-A1 | HETEROCYCLE-SUBSTITUTED PTERIDINE DERIVATIVES AND THEIR USE IN THERAPY | 4 AZA BIOSCIENCE NV (BE) | 2005-05-06 | — | — | WO | disclosed |