Sugi Predict

Sugi Predict / Compounds / SCHEMBL5598204

SCHEMBL5598204

SCHEMBL5598204

COc1ccc(C=CC(=O)c2ccco2)cc1

nearest known ligand 0.73

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ MAOB P27338 6/20 0.73
▸ MAOA P21397 3/20 0.73
▸ MAPT P10636 6/20 0.67
▸ RAB9A P51151 4/20 0.67
▸ MEN1 O00255 3/20 0.67
▸ KMT2A Q03164 3/20 0.67
▸ LMNA P02545 2/20 0.67
▸ PSMD14 O00487 1/20 0.67
▸ CRHBP P24387 1/20 0.67
▸ CRHR2 Q13324 1/20 0.67
▸ CAPN1 P07384 1/20 0.66
▸ CTSB P07858 1/20 0.66
▸ HTT P42858 2/20 0.62
▸ F3 P13726 2/20 0.60
▸ ALDH1A1 P00352 3/20 0.60
▸ KDM4E B2RXH2 2/20 0.60
▸ HPGD P15428 2/20 0.60
▸ TP53 P04637 1/20 0.60
▸ TDP1 Q9NUW8 1/20 0.60
▸ L3MBTL1 Q9Y468 1/20 0.60

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL1820821 1.00 MAOB (0.73) MAOBMAOAMAPTRAB9AMEN1
SCHEMBL5598009 0.84 MAPT (0.66) MAOBMAOAMAPTRAB9AMEN1
SCHEMBL16810345 0.83 MAOB (1.00) MAOBMAOAMAPTRAB9AMEN1
SCHEMBL5597968 0.81 MAPT (0.74) MAOBMAOAMAPTRAB9AMEN1
SCHEMBL2053346 0.81 MAPT (0.79) MAOBMAOAMAPTRAB9AMEN1
SCHEMBL979280 0.81 MAPT (0.79) MAOBMAOAMAPTRAB9AMEN1
SCHEMBL11080373 0.81 ABCG2 (0.65) MAOBMAOAMAPTRAB9AMEN1
SCHEMBL11080376 0.81 ABCG2 (0.65) MAOBMAOAMAPTRAB9AMEN1
SCHEMBL3096975 0.80 MAPT (0.77) MAOBMAOAMAPTRAB9AMEN1
SCHEMBL13721173 0.80 MAPT (1.00) MAOBMAOAMAPTRAB9AMEN1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 18 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2810198-B1 ANTI-INVASIVE COMPOUNDS UNIV GENT (BE) 2023-07-12 — — EP disclosed
US-11375716-B2 Acetyl-CoA carboxylase modulators MONSANTO TECHNOLOGY LLC (US) 2022-07-05 — — US disclosed
US-20200214289-A1 ACETYL-COA CARBOXYLASE MODULATORS MONSANTO TECHNOLOGY LLC (US) 2020-07-09 — — US disclosed
US-10548313-B2 Acetyl-CoA carboxylase modulators MONSANTO TECHNOLOGY LLC (US) 2020-02-04 — — US disclosed
US-20180070589-A1 ACETYL-COA CARBOXYLASE MODULATORS MONSANTO TECHNOLOGY LLC (US) 2018-03-15 — — US disclosed
US-9844218-B2 Acetyl-CoA carboxylase modulators MONSANTO TECHNOLOGY LLC (US) 2017-12-19 — — US disclosed
US-20160130229-A1 ACETYL-COA CARBOXYLASE MODULATORS MONSANTO TECHNOLOGY LLC (US) 2016-05-12 — — US disclosed
US-9290427-B2 Anti-invasive compounds UNIVERSITEIT GENT (BE) 2016-03-22 — — US disclosed
US-20150011620-A1 ANTI-INVASIVE COMPOUNDS UNIVERSITEIT GENT (BE) 2015-01-08 — — US disclosed
WO-2014201326-A1 ACETYL-COA CARBOXYLASE MODULATORS MONSANTO TECHNOLOGY LLC (US) 2014-12-18 — — WO disclosed
EP-2810198-A1 ANTI-INVASIVE COMPOUNDS Universiteit Gent (BE) 2014-12-10 — — EP disclosed
WO-2013113722-A1 ANTI-INVASIVE COMPOUNDS UNIVERSITEIT GENT (BE) 2013-08-08 — — WO disclosed
EP-1815860-A2 Phosphate transport inhibitors GENZYME CORPORATION (US) 2007-08-08 — — EP disclosed
US-20070021509-A1 Phosphate transport inhibitors JOZEFIAK THOMAS H 2007-01-25 — — US disclosed
US-7119120-B2 Phosphate transport inhibitors GENZYME CORPORATION (US) 2006-10-10 — — US disclosed
EP-1465638-A2 PHOSPHATE TRANSPORT INHIBITORS GENZYME CORPORATION (US) 2004-10-13 — — EP disclosed
US-20040019113-A1 Phosphate transport inhibitors GELTEX PHARMACEUTICALS, INC. 2004-01-29 — — US disclosed
WO-2003057225-A2 PHOSPHATE TRANSPORT INHIBITORS GENZYME CORPORATION (US) 2003-07-17 — — WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (8 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20160130229-A1 ACETYL-COA CARBOXYLASE MODULATORS ACACA, ACACB, ACAT2 MAOB 2334/4885MAOA 1948/4885MAPT 2150/4885
US-20040019113-A1 Phosphate transport inhibitors SLC34A1, SLC34A2, SLC20A1 MAOB 675/4885MAOA 735/4885MAPT 3148/4885
US-11375716-B2 Acetyl-CoA carboxylase modulators ACACA, ACACB, ACAT2 MAOB 2334/4885MAOA 1948/4885MAPT 2150/4885
US-10548313-B2 Acetyl-CoA carboxylase modulators ACACA, ACACB, ACAT2 MAOB 2334/4885MAOA 1948/4885MAPT 2150/4885
US-20200214289-A1 ACETYL-COA CARBOXYLASE MODULATORS ACACA, ACACB, ACAT2 MAOB 2334/4885MAOA 1948/4885MAPT 2150/4885
US-20150011620-A1 ANTI-INVASIVE COMPOUNDS MMP3, MMP10, MIF MAOB 4150/4885MAOA 4248/4885MAPT 3571/4885
US-20070021509-A1 Phosphate transport inhibitors SLC34A2, SLC34A1, SLC20A1 MAOB 698/4885MAOA 1058/4885MAPT 3058/4885
US-20180070589-A1 ACETYL-COA CARBOXYLASE MODULATORS ACACA, ACACB, ACAT2 MAOB 2334/4885MAOA 1948/4885MAPT 2150/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.