Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 2/20 | 0.38 |
| ▸ | MAPT | P10636 | 2/20 | 0.38 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | MGLL | Q99685 | 1/20 | 0.34 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | SMYD3 | Q9H7B4 | 2/20 | 0.34 |
| ▸ | HCRTR1 | O43613 | 1/20 | 0.33 |
| ▸ | HCRTR2 | O43614 | 1/20 | 0.33 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.33 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.33 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.33 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.33 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.33 |
| ▸ | GNRHR | P30968 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5599340 | 0.90 | L3MBTL1 (0.36) | LMNATSHRHTTPOLBL3MBTL1 | |
| SCHEMBL5777915 | 0.87 | ALDH1A1 (0.34) | LMNAPOLBL3MBTL1ALDH1A1MGLL | |
| SCHEMBL5784243 | 0.75 | GNRHR (0.42) | LMNAMAPTTSHRHTTSMYD3 | |
| SCHEMBL5599571 | 0.72 | PTGDR2 (0.37) | TSHRHTTL3MBTL1ALDH1A1CHRM2 | |
| SCHEMBL5780173 | 0.72 | DRD2 (0.36) | TSHRL3MBTL1ALDH1A1HCRTR1HCRTR2 | |
| SCHEMBL5599289 | 0.71 | DRD2 (0.37) | L3MBTL1ALDH1A1SMYD3HCRTR1HCRTR2 | |
| SCHEMBL5600563 | 0.71 | TSHR (0.36) | TSHRHTTL3MBTL1ALDH1A1CHRM2 | |
| SCHEMBL5599363 | 0.71 | CHRM1 (0.38) | TSHRCHRM2CHRM4CHRM5CHRM1 | |
| SCHEMBL5599763 | 0.71 | DRD2 (0.38) | L3MBTL1ALDH1A1MGLLCHRM2CHRM4 | |
| SCHEMBL5780283 | 0.70 | PTGDR2 (0.36) | LMNAMAPTMEN1KMT2ACHRM2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2005063745-A9 | NOVEL SPIROINDOLINE OR SPIROISOQUINOLINE COMPOUNDS, METHODS OF USE AND COMPOSITIONS THEREOF | ARENA PHARM INC (US) | 2007-02-01 | — | — | WO | claimed |