Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.34 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.34 |
| ▸ | P2RX7 | Q99572 | 4/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.33 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | PKM | P14618 | 1/20 | 0.33 |
| ▸ | POLB | P06746 | 1/20 | 0.33 |
| ▸ | MGLL | Q99685 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 2/20 | 0.32 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.32 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.32 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.32 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.32 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.32 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.32 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.32 |
| ▸ | GRM5 | P41594 | 1/20 | 0.32 |
| ▸ | AVPR2 | P30518 | 1/20 | 0.32 |
| ▸ | AVPR1A | P37288 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5599340 | 0.88 | L3MBTL1 (0.36) | ALDH1A1L3MBTL1SMN1; SMN2TDP1KDM4E | |
| SCHEMBL5598980 | 0.87 | LMNA (0.38) | ALDH1A1L3MBTL1POLBMGLLLMNA | |
| SCHEMBL5784243 | 0.71 | GNRHR (0.42) | KDM4ELMNASMYD3HCRTR1HCRTR2 | |
| SCHEMBL5599571 | 0.70 | PTGDR2 (0.37) | ALDH1A1L3MBTL1P2RX7SMN1; SMN2TDP1 | |
| SCHEMBL5599289 | 0.70 | DRD2 (0.37) | ALDH1A1L3MBTL1P2RX7CHRM2CHRM4 | |
| SCHEMBL5600563 | 0.70 | TSHR (0.36) | ALDH1A1L3MBTL1P2RX7SMN1; SMN2TDP1 | |
| SCHEMBL5599763 | 0.69 | DRD2 (0.38) | ALDH1A1L3MBTL1P2RX7MGLLCHRM2 | |
| SCHEMBL5780173 | 0.68 | DRD2 (0.36) | ALDH1A1L3MBTL1P2RX7CHRM2CHRM4 | |
| SCHEMBL5782306 | 0.67 | HTR2A (0.40) | LMNASMYD3HCRTR1HCRTR2 | |
| SCHEMBL5599363 | 0.67 | CHRM1 (0.38) | CHRM2CHRM4CHRM5CHRM1CHRM3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1716148-A2 | NOVEL SPIROINDOLINE OR SPIROISOQUINOLINE COMPOUNDS, METHODS OF USE AND COMPOSITIONS THEREOF | Arena Pharmaceuticals, Inc. (US) | 2006-11-02 | — | — | EP | claimed |
| WO-2005063745-A2 | NOVEL SPIROINDOLINE OR SPIROISOQUINOLINE COMPOUNDS, METHODS OF USE AND COMPOSITIONS THEREOF | ARENA PHARMACEUTICALS, INC. (US) | 2005-07-14 | — | — | WO | claimed |