Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGD | P15428 | 4/20 | 0.41 |
| ▸ | GAA | P10253 | 2/20 | 0.41 |
| ▸ | TSHR | P16473 | 5/20 | 0.41 |
| ▸ | MEN1 | O00255 | 2/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.40 |
| ▸ | NPC1 | O15118 | 2/20 | 0.39 |
| ▸ | RAB9A | P51151 | 2/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 2/20 | 0.38 |
| ▸ | USP2 | O75604 | 1/20 | 0.38 |
| ▸ | GFER | P55789 | 1/20 | 0.37 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5599793 | 0.81 | LMNA (0.44) | HPGDGAAMEN1KMT2AALDH1A1 | |
| SCHEMBL5600810 | 0.81 | NPC1 (0.43) | HPGDGAATSHRKMT2AALDH1A1 | |
| SCHEMBL5599295 | 0.76 | TSHR (0.47) | HPGDGAATSHRALDH1A1L3MBTL1 | |
| SCHEMBL5783881 | 0.75 | TSHR (0.49) | HPGDGAATSHRALDH1A1RAB9A | |
| SCHEMBL5781699 | 0.74 | GLA (0.39) | KMT2AALDH1A1NPC1L3MBTL1LMNA | |
| SCHEMBL5599176 | 0.74 | GLA (0.39) | KMT2AALDH1A1NPC1L3MBTL1LMNA | |
| SCHEMBL5599670 | 0.71 | CYP2C19 (0.44) | HPGDMEN1KMT2AALDH1A1NPC1 | |
| SCHEMBL5599866 | 0.70 | CHRM5 (0.35) | MEN1KMT2A | |
| SCHEMBL5779846 | 0.69 | KMT2A (0.40) | MEN1KMT2AALDH1A1SMN1; SMN2 | |
| SCHEMBL5785402 | 0.67 | GABRD (0.31) | SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2005063745-A9 | NOVEL SPIROINDOLINE OR SPIROISOQUINOLINE COMPOUNDS, METHODS OF USE AND COMPOSITIONS THEREOF | ARENA PHARM INC (US) | 2007-02-01 | — | — | WO | claimed |