Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GNRHR | P30968 | 2/20 | 0.34 |
| ▸ | SMYD3 | Q9H7B4 | 2/20 | 0.33 |
| ▸ | PAX8 | Q06710 | 1/20 | 0.33 |
| ▸ | DRD2 | P14416 | 1/20 | 0.32 |
| ▸ | DRD3 | P35462 | 1/20 | 0.32 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.32 |
| ▸ | TP53 | P04637 | 1/20 | 0.32 |
| ▸ | TSHR | P16473 | 1/20 | 0.32 |
| ▸ | HTT | P42858 | 1/20 | 0.32 |
| ▸ | ACHE | P22303 | 2/20 | 0.31 |
| ▸ | BCHE | P06276 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5783958 | 0.90 | PAX8 (0.41) | SMYD3PAX8TP53 | |
| SCHEMBL5778222 | 0.85 | SMYD3 (0.34) | GNRHRSMYD3PAX8KCNH2TSHR | |
| SCHEMBL5599482 | 0.83 | HTT (0.37) | SMYD3TSHRHTT | |
| SCHEMBL5780422 | 0.79 | P2RX7 (0.36) | GNRHRDRD2KCNH2 | |
| SCHEMBL5786885 | 0.78 | GNRHR (0.33) | GNRHRDRD2KCNH2TP53 | |
| SCHEMBL5599667 | 0.78 | ATM (0.37) | DRD2TSHRHTTBCHE | |
| SCHEMBL5786887 | 0.77 | GNRHR (0.41) | GNRHRDRD2KCNH2 | |
| SCHEMBL5788788 | 0.75 | ALDH1A1 (0.38) | GNRHRKCNH2TP53TSHRHTT | |
| SCHEMBL5781243 | 0.74 | CYP1A2 (0.36) | TP53 | |
| SCHEMBL5599757 | 0.74 | SIGMAR1 (0.40) | DRD2TP53TSHRHTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2005063745-A9 | NOVEL SPIROINDOLINE OR SPIROISOQUINOLINE COMPOUNDS, METHODS OF USE AND COMPOSITIONS THEREOF | ARENA PHARM INC (US) | 2007-02-01 | — | — | WO | claimed |