Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGD | P15428 | 1/20 | 0.34 |
| ▸ | GRM5 | P41594 | 1/20 | 0.33 |
| ▸ | HCRTR1 | O43613 | 1/20 | 0.33 |
| ▸ | HCRTR2 | O43614 | 1/20 | 0.33 |
| ▸ | DRD2 | P14416 | 1/20 | 0.31 |
| ▸ | ATM | Q13315 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5599667 | 0.81 | ATM (0.37) | HPGDGRM5HCRTR1HCRTR2DRD2 | |
| SCHEMBL5780422 | 0.79 | P2RX7 (0.36) | HPGDGRM5HCRTR1HCRTR2DRD2 | |
| SCHEMBL5599482 | 0.74 | HTT (0.37) | — | |
| SCHEMBL5778222 | 0.72 | SMYD3 (0.34) | — | |
| SCHEMBL5781243 | 0.70 | CYP1A2 (0.36) | — | |
| SCHEMBL5783958 | 0.70 | PAX8 (0.41) | — | |
| SCHEMBL5780173 | 0.69 | DRD2 (0.36) | HPGDHCRTR1HCRTR2DRD2 | |
| SCHEMBL5783150 | 0.68 | PTGDR2 (0.36) | HPGDHCRTR1HCRTR2DRD2 | |
| SCHEMBL5579040 | 0.68 | HPGD (0.38) | HPGDGRM5HCRTR1HCRTR2DRD2 | |
| SCHEMBL5599317 | 0.67 | GNRHR (0.34) | DRD2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2005063745-A9 | NOVEL SPIROINDOLINE OR SPIROISOQUINOLINE COMPOUNDS, METHODS OF USE AND COMPOSITIONS THEREOF | ARENA PHARM INC (US) | 2007-02-01 | — | — | WO | claimed |
| EP-1716148-A2 | NOVEL SPIROINDOLINE OR SPIROISOQUINOLINE COMPOUNDS, METHODS OF USE AND COMPOSITIONS THEREOF | Arena Pharmaceuticals, Inc. (US) | 2006-11-02 | — | — | EP | claimed |
| WO-2005063745-A2 | NOVEL SPIROINDOLINE OR SPIROISOQUINOLINE COMPOUNDS, METHODS OF USE AND COMPOSITIONS THEREOF | ARENA PHARMACEUTICALS, INC. (US) | 2005-07-14 | — | — | WO | claimed |