Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DPP4 | P27487 | 1/20 | 0.36 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.35 |
| ▸ | GNRHR | P30968 | 1/20 | 0.35 |
| ▸ | PRKAG1 | P54619 | 1/20 | 0.35 |
| ▸ | PRKAA1 | Q13131 | 1/20 | 0.35 |
| ▸ | PRKAB1 | Q9Y478 | 1/20 | 0.35 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.33 |
| ▸ | CNR1 | P21554 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | PKM | P14618 | 1/20 | 0.33 |
| ▸ | CTSS | P25774 | 3/20 | 0.33 |
| ▸ | KIF11 | P52732 | 1/20 | 0.33 |
| ▸ | CTSL | P07711 | 1/20 | 0.32 |
| ▸ | CTSK | P43235 | 1/20 | 0.32 |
| ▸ | FKBP1A | P62942 | 1/20 | 0.32 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5600486 | 0.92 | GNRHR (0.36) | DPP4GNRHRALDH1A1KMT2AMEN1 | |
| SCHEMBL5599362 | 0.86 | TPSAB1 (0.37) | DPP4AKR1C3PRKAG1PRKAA1PRKAB1 | |
| SCHEMBL5786885 | 0.82 | GNRHR (0.33) | DPP4GNRHRCNR1KMT2AMEN1 | |
| SCHEMBL5778387 | 0.79 | OPRM1 (0.35) | DPP4GNRHR | |
| SCHEMBL5599105 | 0.79 | CHRNB2 (0.34) | DPP4GNRHR | |
| SCHEMBL5780824 | 0.79 | GNRHR (0.37) | DPP4GNRHRHDAC6 | |
| SCHEMBL5786887 | 0.77 | GNRHR (0.41) | GNRHR | |
| SCHEMBL5599768 | 0.77 | GNRHR (0.36) | DPP4GNRHR | |
| SCHEMBL5780422 | 0.77 | P2RX7 (0.36) | DPP4GNRHRALDH1A1 | |
| SCHEMBL5599230 | 0.77 | TPSAB1 (0.38) | DPP4GNRHRALDH1A1CTSS |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2005063745-A9 | NOVEL SPIROINDOLINE OR SPIROISOQUINOLINE COMPOUNDS, METHODS OF USE AND COMPOSITIONS THEREOF | ARENA PHARM INC (US) | 2007-02-01 | — | — | WO | claimed |