Known targets — ChEMBL curated mechanism
ABCC9ABL1ACEACHEACVR1ADORA1ADORA2AADORA2BADORA3ADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ADRB3AGTR1ALOX5ATP4AATP4BBCRBTKCACNA1ACACNA1BCACNA1CCACNA1DCACNA1ECACNA1FCACNA1GCACNA1HCACNA1ICACNA1SCACNA2D1CACNA2D2CACNA2D3CACNA2D4CACNB1CACNB2CACNB3CACNB4CACNG1CACNG2CACNG3CACNG4CACNG5CACNG6CACNG7CACNG8CALCRLCFBCHRM1CHRM2CHRM3CHRM4CHRM5CHRNA1CHRNB1CHRNDCHRNECHRNGCRBNCUL4ACXCR1CXCR2DDB1DDCDHFRDPP4DRD2DRD3DRD4EGFRERBB2ERBB4ESR1ESR2FDPSFKBP1AFLT1FLT3FLT4GARTGHSRGRIA1GRIA2GRIA3GRIA4GRIK1GRIK2GRIK3GRIK4GRIK5GRIN2AGSK3AGSK3BHDAC1HDAC10HDAC11HDAC2HDAC3HDAC4HDAC5HDAC6HDAC7HDAC8HDAC9HRH1HTR1AHTR1BHTR1DHTR1EHTR1FHTR2AHTR2BHTR2CHTR3AHTR3BHTR3CHTR3DHTR3EHTR4HTR5AHTR6HTR7IDH1IDH2IMPA1ITGA2BITGB3JAK1JAK2JAK3KCNJ11KCNK3KCNK9KDRKITMEN1METMMP1MMP13MMP7MMP8NANOD2NS5bODC1OPG057OPRD1OPRK1OPRM1PPARP1PARP2PDE3APDE3BPDE4APDE4BPDE4CPDE4DPDGFRBPIK3CAPIK3CBPIK3CDPIK3CGPIK3R1PIK3R2PIK3R3PIK3R5PKLRPPARDPPATPTGS1PTGS2RBX1ROCK1ROCK2RRM1RRM2RRM2BSCN10ASCN11ASCN1ASCN2ASCN3ASCN4ASCN5ASCN7ASCN8ASCN9ASCNN1ASCNN1BSCNN1GSIGMAR1SLC10A2SLC5A2SLC6A2SLC6A3SLC6A4SLC9A3SYKTACR1THRATHRBTOP1TUBA1ATUBA1BTUBA1CTUBA3CTUBA3ETUBA4ATUBBTUBB1TUBB2ATUBB2BTUBB3TUBB4ATUBB4BTUBB6TUBB8TYK2TYMSVDRampCblablaT-3blaT-4blaT-5blaT-6blaUOE-1dacAdacBdacCfolAfolPftsIgyrAgyrBileSmecAmrcAmrcBmrdAparCparEpbp2pbp4pbpApbpFrplArplBrplCrplDrplErplFrplIrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmE2rpmFrpmGrpmG1rpmG2rpmG3rpmHrpmIrpmJrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUthyAykgMykgO
The experimentally established mechanism targets of Phenolsulfonic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 known ✓ | O00255 | 1/20 | 0.44 |
| ▸ | THRB known ✓ | P10828 | 1/20 | 0.44 |
| ▸ | ESR1 known ✓ | P03372 | 2/20 | 0.43 |
| ▸ | LMNA | P02545 | 2/20 | 0.94 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.56 |
| ▸ | CA2 | P00918 | 4/20 | 0.56 |
| ▸ | CA12 | O43570 | 3/20 | 0.56 |
| ▸ | CA9 | Q16790 | 3/20 | 0.56 |
| ▸ | TSHR | P16473 | 2/20 | 0.56 |
| ▸ | CA1 | P00915 | 2/20 | 0.56 |
| ▸ | NT5E | P21589 | 1/20 | 0.56 |
| ▸ | ENPP2 | Q13822 | 1/20 | 0.56 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.55 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.50 |
| ▸ | HSD17B10 | Q99714 | 4/20 | 0.47 |
| ▸ | HPGD | P15428 | 3/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.47 |
| ▸ | POLB | P06746 | 1/20 | 0.46 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.46 |
| ▸ | GAA | P10253 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Phenolsulfonic Acid SCHEMBL687364 | 1.00 | LMNA (0.94) | LMNAALDH1A1CA2CA12CA9 | |
| Phenolsulfonic Acid SCHEMBL28288398 | 0.97 | LMNA (0.90) | LMNAALDH1A1CA2CA12CA9 | |
| Phenolsulfonic Acid SCHEMBL710821 | 0.97 | LMNA (0.90) | LMNAALDH1A1CA2CA12CA9 | |
| Phenolsulfonic Acid SCHEMBL1115419 | 0.97 | LMNA (0.90) | LMNAALDH1A1CA2CA12CA9 | |
| Phenolsulfonic Acid SCHEMBL18275 | 0.97 | LMNA (1.00) | LMNAALDH1A1CA2CA12CA9 | |
| Phenolsulfonic Acid SCHEMBL29965481 | 0.97 | LMNA (1.00) | LMNAALDH1A1CA2CA12CA9 | |
| Phenolsulfonic Acid SCHEMBL10622999 | 0.97 | LMNA (1.00) | LMNAALDH1A1CA2CA12CA9 | |
| Phenolsulfonic Acid SCHEMBL2518117 | 0.94 | LMNA (0.94) | LMNAALDH1A1CA2CA12CA9 | |
| Phenolsulfonic Acid SCHEMBL20815893 | 0.94 | LMNA (0.94) | LMNAALDH1A1CA2CA12CA9 | |
| Phenolsulfonic Acid SCHEMBL9682015 | 0.94 | LMNA (0.94) | LMNAALDH1A1CA2CA12CA9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 58 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3091053-B1 | OPTICAL FLUORESCENT IMAGING USING CYANINE DYES | LI COR INC (US) | 2020-12-23 | — | — | EP | disclosed |
| EP-3091053-A1 | OPTICAL FLUORESCENT IMAGING USING CYANINE DYES | LI-COR, INC. (US) | 2016-11-09 | — | — | EP | disclosed |
| US-20160280650-A1 | NOVEL BENZENESULFONAMIDE COMPOUNDS, METHOD FOR SYNTHESIZING SAME, AND USE THEREOF IN MEDICINE AS WELL AS IN COSMETICS | GALDERMA RESEARCH & DEVELOPMENT (FR) | 2016-09-29 | — | — | US | disclosed |
| US-9365529-B2 | Benzenesulfonamide compounds, method for synthesizing same, and use thereof in medicine as well as in cosmetics | GALDERMA RESEARCH & DEVLOPMENT (FR) | 2016-06-14 | — | — | US | disclosed |
| EP-2035505-B1 | OPTICAL FLUORESCENT IMAGING USING CYANINE DYES | LI COR INC (US) | 2016-03-16 | — | — | EP | disclosed |
| EP-2968314-A2 | NOVEL BENZENESULFONAMIDE COMPOUNDS, METHOD FOR SYNTHESIZING SAME, AND USE THEREOF IN MEDICINE AS WELL AS IN COSMETICS | Galderma Research & Development (FR) | 2016-01-20 | — | — | EP | disclosed |
| CN-105228624-A | Novel benzenesulfonamide compounds, method for the synthesis thereof and use thereof in medicine and cosmetics | GALDERMA RES & DEV | 2016-01-06 | — | — | CN | disclosed |
| US-9110069-B2 | Luminescent compounds | SETA BIOMEDICALS, LLC (US) | 2015-08-18 | — | — | US | disclosed |
| CN-103059640-B | Inkjet ink, inkjet recording method, ink cartridge, recording unit, and inkjet recording apparatus | CANON KK | 2015-06-24 | — | — | CN | disclosed |
| US-20150158834-A1 | NOVEL BENZENESULFONAMIDE COMPOUNDS, METHOD FOR SYNTHESIZING SAME, AND USE THEREOF IN MEDICINE AS WELL AS IN COSMETICS | GALDERMA RESEARCH & DEVELOPMENT (FR) | 2015-06-11 | — | — | US | disclosed |
| EP-1202961-A1 | ARYLSULFONAMIDO-SUBSTITUTED HYDROXAMIC ACID DERIVATIVES | Novartis AG (CH) | 2002-05-08 | — | — | EP | disclosed |
| WO-2002024815-A1 | CYANINE DYES | LI-COR, INC. (US) | 2002-03-28 | — | — | WO | disclosed |
| WO-2001010827-A1 | ARYLSULFONAMIDO-SUBSTITUTED HYDROXAMIC ACID DERIVATIVES | NOVARTIS AG (CH) | 2001-02-15 | — | — | WO | disclosed |
| EP-0979104-A1 | SONODYNAMIC THERAPY USING AN ULTRASOUND SENSITIZER COMPOUND | NYCOMED IMAGING A/S (NO) | 2000-02-16 | — | — | EP | disclosed |
| WO-1998052609-A1 | SONODYNAMIC THERAPY USING AN ULTRASOUND SENSITIZER COMPOUND | NYCOMED IMAGING AS (NO) | 1998-11-26 | — | — | WO | disclosed |
| EP-0383995-B1 | Aromatic thermosetting resins and preparation thereof | SUMIKIN CHEMICAL (JP) | 1997-10-15 | — | — | EP | disclosed |
| US-5536626-A | CYCLOALKENYLENE CONTAINING CYANINE DYE | E. I. DU PONT DE NEMOURS AND COMPANY (US) | 1996-07-16 | — | — | US | disclosed |
| US-5519145-A | CATIONIC INDOLIUM DYES FOR PHOTOGRAPHY | E. I. DU PONT DE NEMOURS AND COMPANY (US) | 1996-05-21 | — | — | US | disclosed |
| US-5017683-A | Organic acid catalyst | SUMIKIN CHEMICAL CO., LTD. (JP) | 1991-05-21 | — | — | US | disclosed |
| EP-0383995-A2 | Aromatic thermosetting resins and preparation thereof | SUMIKIN CHEMICAL CO., LTD. (JP) | 1990-08-29 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20160280650-A1 | NOVEL BENZENESULFONAMIDE COMPOUNDS, METHOD FOR SYNTHESIZING SAME, AND USE THEREOF IN MEDICINE AS WELL AS IN COSMETICS | TYR, ARSA, NISCH | MEN1 2111/4885THRB 4458/4885ESR1 3085/4885 |
| US-20150158834-A1 | NOVEL BENZENESULFONAMIDE COMPOUNDS, METHOD FOR SYNTHESIZING SAME, AND USE THEREOF IN MEDICINE AS WELL AS IN COSMETICS | TYR, ARSA, NISCH | MEN1 2111/4885THRB 4458/4885ESR1 3085/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.