Known targets — ChEMBL curated mechanism
ACHEBDKRB2CHRM1CHRM2CHRM3CHRNA1CHRNB1CHRNDCHRNECHRNGGUCY1A1GUCY1A2GUCY1B1GUCY1B2NAMPTPTAFRSLC10A2SLC6A2SLC6A3TACR1dacAdacBdacCftsImrcAmrcBmrdA
The experimentally established mechanism targets of Hydrochloric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRM2 known ✓ | P08172 | 1/20 | 0.30 |
| ▸ | CHRM1 known ✓ | P11229 | 1/20 | 0.30 |
| ▸ | CHRM3 known ✓ | P20309 | 1/20 | 0.30 |
| ▸ | SLC6A2 known ✓ | P23975 | 1/20 | 0.30 |
| ▸ | HTR2A | P28223 | 2/20 | 0.39 |
| ▸ | GPR3 | P46089 | 1/20 | 0.32 |
| ▸ | POLB | P06746 | 1/20 | 0.32 |
| ▸ | MLNR | O43193 | 1/20 | 0.30 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.30 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.30 |
| ▸ | HTR1A | P08908 | 1/20 | 0.30 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.30 |
| ▸ | DRD2 | P14416 | 1/20 | 0.30 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.30 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.30 |
| ▸ | DRD1 | P21728 | 1/20 | 0.30 |
| ▸ | HTR2C | P28335 | 1/20 | 0.30 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.30 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.30 |
| ▸ | HRH1 | P35367 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL3352462 | 0.73 | GPR3 (0.32) | GPR3POLB | |
| Hydrochloric Acid SCHEMBL5616477 | 0.72 | HTR1A (0.38) | HTR2AHTR1ADRD2 | |
| Hydrochloric Acid SCHEMBL5616436 | 0.69 | ALDH1A1 (0.31) | HTR2AGPR3POLB | |
| SCHEMBL18590940 | 0.67 | HTR2A (0.40) | HTR2ASLC6A2HTR2CSLC6A4PDK2 | |
| Hydrochloric Acid SCHEMBL5616377 | 0.66 | BRD4 (0.31) | — | |
| SCHEMBL283246 | 0.64 | HTR2A (0.48) | HTR2AMLNRNR1I2CHRM2ADRB1 | |
| SCHEMBL29363404 | 0.64 | HTR2A (0.48) | HTR2AMLNRNR1I2CHRM2ADRB1 | |
| SCHEMBL24729587 | 0.62 | HTR2A (0.47) | HTR2AMLNRNR1I2CHRM2ADRB1 | |
| Benzene SCHEMBL28919541 | 0.62 | PGR (0.48) | HTR2AMLNRNR1I2CHRM2ADRB1 | |
| Lithium SCHEMBL30363455 | 0.62 | HTR2A (0.47) | HTR2AMLNRNR1I2CHRM2ADRB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2007023618-A1 | HOMOPOLYMER AND COPOLYMER, AND PRODUCTION PROCESS THEREOF | SUMITOMO CHEMICAL COMPANY, LIMITED (JP) | 2007-03-01 | — | — | WO | disclosed |