Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRK5 | P34947 | 1/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.45 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.45 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.45 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.45 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.44 |
| ▸ | BRD4 | O60885 | 2/20 | 0.44 |
| ▸ | LIN28A | Q9H9Z2 | 1/20 | 0.44 |
| ▸ | LMNA | P02545 | 2/20 | 0.43 |
| ▸ | MAPT | P10636 | 2/20 | 0.43 |
| ▸ | HPGD | P15428 | 2/20 | 0.43 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.43 |
| ▸ | HTT | P42858 | 1/20 | 0.42 |
| ▸ | PIM1 | P11309 | 2/20 | 0.42 |
| ▸ | DPP4 | P27487 | 3/20 | 0.41 |
| ▸ | DCTPP1 | Q9H773 | 1/20 | 0.41 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29617977 | 0.84 | DPP4 (0.54) | KDM4EHSD17B10CYP1A2CYP2C9CYP2C19 | |
| SCHEMBL24401671 | 0.84 | DPP4 (0.54) | KDM4EHSD17B10CYP1A2CYP2C9CYP2C19 | |
| SCHEMBL32665417 | 0.81 | DYRK3 (0.58) | KDM4EHSD17B10CYP1A2CYP2C9CYP2C19 | |
| SCHEMBL15365501 | 0.79 | KDM4E (0.65) | KDM4EHSD17B10CYP1A2CYP2C9CYP2C19 | |
| SCHEMBL12874554 | 0.79 | DYRK3 (0.60) | KDM4EHSD17B10CYP1A2CYP2C9CYP2C19 | |
| SCHEMBL32665401 | 0.78 | PIM1 (0.62) | KDM4EHSD17B10CYP1A2CYP2C9CYP2C19 | |
| SCHEMBL15365361 | 0.78 | PIM1 (0.62) | KDM4EHSD17B10CYP1A2CYP2C9CYP2C19 | |
| SCHEMBL4784567 | 0.78 | BRD4 (0.65) | KDM4EHSD17B10ALDH1A1SMN1; SMN2BRD4 | |
| SCHEMBL29555051 | 0.77 | DYRK1A (0.69) | DYRK3CCNT1CCNA2CDK2CDK9 | |
| SCHEMBL26915251 | 0.77 | DYRK1A (0.69) | DYRK3CCNT1CCNA2CDK2CDK9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7173033-B2 | Nitrogen-containing heterocyclic compound | ASTELLAS PHARMA INC. (JP) | 2007-02-06 | — | — | US | disclosed |
| US-20060173009-A1 | Agent inducing increase in bone mass | ASTELLAS PHARMA INC. (JP) | 2006-08-03 | — | — | US | disclosed |
| EP-1640010-A1 | AGENT INDUCING INCREASE IN BONE MASS | Astellas Pharma Inc. (JP) | 2006-03-29 | — | — | EP | disclosed |
| US-20050261297-A1 | Nitrogen-containing heterocyclic compound | YAMANOUCHI PHARMACEUTICAL CO., LTD | 2005-11-24 | — | — | US | disclosed |
| US-20050096322-A1 | Nitrogen-containing heterocyclic compound | ASTELLAS PHARMA INC. (JP) | 2005-05-05 | — | — | US | disclosed |
| EP-1481977-A1 | NITROGEN-CONTAINING HETEROCYCLIC COMPOUND | YAMANOUCHI PHARMACEUTICAL CO. LTD. (JP) | 2004-12-01 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050096322-A1 | Nitrogen-containing heterocyclic compound | BMP2, BMP1, BMP4 | GRK5 489/4885KDM4E 2532/4885HSD17B10 3828/4885 |
| US-20050261297-A1 | Nitrogen-containing heterocyclic compound | BMP2, BMP1, BMP4 | GRK5 489/4885KDM4E 2532/4885HSD17B10 3828/4885 |
| US-20060173009-A1 | Agent inducing increase in bone mass | SOST, CALCB, BMP4 | GRK5 527/4885KDM4E 2584/4885HSD17B10 3567/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.