Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 3/20 | 0.50 |
| ▸ | MEN1 | O00255 | 2/20 | 0.50 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.50 |
| ▸ | HDAC2 | Q92769 | 2/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.50 |
| ▸ | GRM5 | P41594 | 1/20 | 0.43 |
| ▸ | MGAM | O43451 | 1/20 | 0.42 |
| ▸ | GAA | P10253 | 1/20 | 0.42 |
| ▸ | SI | P14410 | 1/20 | 0.42 |
| ▸ | MGAM2 | Q2M2H8 | 1/20 | 0.42 |
| ▸ | TP53BP1 | Q12888 | 1/20 | 0.42 |
| ▸ | SYK | P43405 | 1/20 | 0.40 |
| ▸ | NLRP3 | Q96P20 | 2/20 | 0.40 |
| ▸ | TSHR | P16473 | 2/20 | 0.40 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.40 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.40 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.40 |
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2958248 | 0.85 | ALDH1A1 (0.54) | HDAC1HDAC2ALDH1A1GRM5GAA | |
| SCHEMBL1167294 | 0.84 | KMT2A (0.53) | KMT2AMEN1ALDH1A1KDM4EHDAC8 | |
| SCHEMBL290760 | 0.83 | RXFP1 (0.52) | KMT2AMEN1ALDH1A1KDM4ETSHR | |
| SCHEMBL29902970 | 0.83 | KDM4E (0.51) | KMT2AMEN1ALDH1A1KDM4EMGAM | |
| SCHEMBL11772465 | 0.83 | KDM4E (0.51) | KMT2AMEN1ALDH1A1KDM4EMGAM | |
| SCHEMBL1167035 | 0.81 | NPC1 (0.55) | KMT2AMEN1HDAC1ALDH1A1KDM4E | |
| SCHEMBL1167517 | 0.81 | ERCC5 (0.58) | KMT2AMEN1ALDH1A1KDM4EGAA | |
| SCHEMBL4628989 | 0.81 | KMT2A (0.50) | KMT2AMEN1ALDH1A1KDM4EHDAC8 | |
| SCHEMBL4206161 | 0.81 | KDM4E (0.54) | KMT2AMEN1ALDH1A1KDM4ETSHR | |
| SCHEMBL13249005 | 0.81 | KDM4E (0.50) | KMT2AMEN1ALDH1A1KDM4EMGAM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 53 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2822940-B1 | NOVEL COMPOUNDS FOR THE TREATMENT OF DYSLIPIDEMIA AND RELATED DISEASES | CADILA HEALTHCARE LTD (IN) | 2017-02-15 | — | — | EP | claimed |
| US-9273041-B2 | Compounds for the treatment of dyslipidemia and related diseases | CADILA HEALTHCARE LIMITED (IN) | 2016-03-01 | — | — | US | claimed |
| US-20150099696-A1 | NOVEL COMPOUNDS FOR THE TREATMENT OF DYSLIPIDEMIA AND RELATED DISEASES | CADILA HEALTHCARE LIMITED (IN) | 2015-04-09 | — | — | US | claimed |
| EP-2822940-A1 | NOVEL COMPOUNDS FOR THE TREATMENT OF DYSLIPIDEMIA AND RELATED DISEASES | Cadila Healthcare Limited (IN) | 2015-01-14 | — | — | EP | claimed |
| WO-2013132509-A1 | NOVEL COMPOUNDS FOR THE TREATMENT OF DYSLIPIDEMIA AND RELATED DISEASES | CADILA HEALTHCARE LIMITED (IN) | 2013-09-12 | — | — | WO | claimed |
| US-20220324814-A1 | CALPAIN MODULATORS AND THERAPEUTIC USES THEREOF | BLADE THERAPEUTICS INC (US) | 2022-10-13 | — | — | US | disclosed |
| US-11339130-B1 | Calpain modulators and therapeutic uses thereof | BLADE THERAPEUTICS, INC. (US) | 2022-05-24 | — | — | US | disclosed |
| CN-105980386-B | Pyrazolo compounds and uses thereof | 基因泰克公司 | 2021-08-13 | — | — | CN | disclosed |
| US-10934261-B2 | Calpain modulators and therapeutic uses thereof | BLADE THERAPEUTICS, INC. (US) | 2021-03-02 | — | — | US | disclosed |
| US-10894776-B2 | — | — | 2021-01-19 | — | — | US | disclosed |
| US-20200123114-A1 | CALPAIN MODULATORS AND THERAPEUTIC USES THEREOF | BLADE THERAPEUTICS, INC. (US) | 2020-04-23 | — | — | US | disclosed |
| EP-2970307-B1 | PYRAZOLO COMPOUNDS AND USES THEREOF | GENENTECH INC (US) | 2020-03-11 | — | — | EP | disclosed |
| US-20140066404-A1 | PYRAZOLE DERIVATIVES, PREPARATION METHOD THEREOF, AND COMPOSITION FOR PREVENTION AND TREATMENT OF OSTEOPOROSIS CONTAINING SAME | EWHA UNIVERSITY-INDUSTRY COLLABORATION FOUNDATION (KR) | 2014-03-06 | — | — | US | disclosed |
| US-8604210-B2 | Pyrazole derivatives, preparation method thereof, and composition for prevention and treatment of osteoporosis containing same | EWHA UNIVERSITY-INDUSTRY COLLABORATION FOUNDATION (KR) | 2013-12-10 | — | — | US | disclosed |
| WO-2013131931-A1 | AMINOMETHYLENE PYRAZOLONES WITH THERAPEUTIC ACTIVITY | COMPOUND HANDLING B.V. (NL) | 2013-09-12 | — | — | WO | disclosed |
| WO-2013132509-A1 | NOVEL COMPOUNDS FOR THE TREATMENT OF DYSLIPIDEMIA AND RELATED DISEASES | CADILA HEALTHCARE LIMITED (IN) | 2013-09-12 | — | — | WO | disclosed |
| US-20120220550-A1 | PYRAZOLE DERIVATIVES, PREPARATION METHOD THEREOF, AND COMPOSITION FOR PREVENTION AND TREATMENT OF OSTEOPOROSIS CONTAINING SAME | EWHA UNIVERSITY- INDUSTRY COLLABORATION FOUNDATION (KR) | 2012-08-30 | — | — | US | disclosed |
| US-7169797-B2 | Protein-tyrosine phosphatase inhibitors and uses thereof | ABBOTT LABORATORIES (US) | 2007-01-30 | — | — | US | disclosed |
| US-20040214870-A1 | Controlling gene expression; antidiabetic agents; insulin resistance; autoimmune disease; 5-(3-((1E)-3-(3-hydroxy-2-(methoxycarbonyl)phenoxy)prop-1-enyl)phenyl)isoxazole-3-carboxylic acid | ABBVIE INC. | 2004-10-28 | — | — | US | disclosed |
| US-20040167188-A1 | Controlling gene expression; antidiabetic agents; insulin resistance; autoimmune disease; | ABBOTT LABORATORIES | 2004-08-26 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (10 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20200123114-A1 | CALPAIN MODULATORS AND THERAPEUTIC USES THEREOF | CAPNS1, CAPN9, CAPN1 | KMT2A 4418/4885MEN1 4845/4885HDAC1 517/4885 |
| US-10934261-B2 | Calpain modulators and therapeutic uses thereof | CAPNS1, CAPN9, CAPN1 | KMT2A 4418/4885MEN1 4845/4885HDAC1 517/4885 |
| US-10894776-B2 | — | CAPNS1, CAPN9, CAPN2 | KMT2A 4469/4885MEN1 4832/4885HDAC1 568/4885 |
| US-20150099696-A1 | NOVEL COMPOUNDS FOR THE TREATMENT OF DYSLIPIDEMIA AND RELATED DISEASES | PCSK9, LIPC, LCAT | KMT2A 3673/4885MEN1 1538/4885HDAC1 1056/4885 |
| US-20120220550-A1 | PYRAZOLE DERIVATIVES, PREPARATION METHOD THEREOF, AND COMPOSITION FOR PREVENTION AND TREATMENT OF OSTEOPOROSIS CONTAINING SAME | PTH1R, VDR, SOST | KMT2A 3628/4885MEN1 1308/4885HDAC1 607/4885 |
| US-20140066404-A1 | PYRAZOLE DERIVATIVES, PREPARATION METHOD THEREOF, AND COMPOSITION FOR PREVENTION AND TREATMENT OF OSTEOPOROSIS CONTAINING SAME | PTH1R, VDR, SOST | KMT2A 3628/4885MEN1 1308/4885HDAC1 607/4885 |
| US-11339130-B1 | Calpain modulators and therapeutic uses thereof | CAPNS1, CAPN9, CAPN1 | KMT2A 4418/4885MEN1 4845/4885HDAC1 517/4885 |
| US-20220324814-A1 | CALPAIN MODULATORS AND THERAPEUTIC USES THEREOF | CAPNS1, CAPN9, CAPN1 | KMT2A 4418/4885MEN1 4845/4885HDAC1 517/4885 |
| US-20040167188-A1 | Controlling gene expression; antidiabetic agents; insulin resistance; autoimmune disease; | G6PC1, PPP1R1B, PPP1R7 | KMT2A 2609/4885MEN1 2107/4885HDAC1 216/4885 |
| US-20040214870-A1 | Controlling gene expression; antidiabetic agents; insulin resistance; autoimmune disease; 5-(3-((1E)-3-(3-hydroxy-2-(methoxycarbonyl)phenoxy)prop-1-enyl)phenyl)isoxazole-3-carboxylic acid | G6PC1, PPP1R7, PPP1R1B | KMT2A 2348/4885MEN1 3309/4885HDAC1 647/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.