Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 1/20 | 0.55 |
| ▸ | MEN1 | O00255 | 2/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.52 |
| ▸ | HPGD | P15428 | 1/20 | 0.44 |
| ▸ | CNR1 | P21554 | 1/20 | 0.43 |
| ▸ | ADRB3 | P13945 | 3/20 | 0.42 |
| ▸ | ADRB1 | P08588 | 2/20 | 0.42 |
| ▸ | METAP2 | P50579 | 4/20 | 0.42 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.42 |
| ▸ | PLAAT3 | P53816 | 1/20 | 0.41 |
| ▸ | PLAAT5 | Q96KN8 | 1/20 | 0.41 |
| ▸ | PLAAT2 | Q9NWW9 | 1/20 | 0.41 |
| ▸ | PLAAT4 | Q9UL19 | 1/20 | 0.41 |
| ▸ | PLA2G1B | P04054 | 1/20 | 0.41 |
| ▸ | ATG4B | Q9Y4P1 | 1/20 | 0.41 |
| ▸ | ATM | Q13315 | 1/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.40 |
| ▸ | METAP1 | P53582 | 3/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL980298 | 0.89 | LMNA (0.46) | LMNAMEN1KMT2AADRB3ADRB1 | |
| SCHEMBL981084 | 0.89 | OPRK1 (0.52) | LMNAMEN1KMT2AATML3MBTL1 | |
| SCHEMBL6767703 | 0.80 | CNR1 (0.53) | LMNAMEN1KMT2ACNR1ADRB3 | |
| SCHEMBL5631220 | 0.79 | MEN1 (0.52) | MEN1KMT2AHPGDCNR1ADRB3 | |
| SCHEMBL4034490 | 0.78 | LMNA (0.45) | LMNATDP1GAA | |
| SCHEMBL5628156 | 0.78 | LMNA (0.57) | LMNAMEN1KMT2AHPGDCNR1 | |
| SCHEMBL6767270 | 0.76 | KMT2A (0.59) | LMNAMEN1KMT2AHPGDADRB3 | |
| SCHEMBL979107 | 0.75 | SLC6A2 (0.51) | LMNAGAA | |
| SCHEMBL10875906 | 0.71 | OPRK1 (0.45) | LMNAMEN1KMT2AHPGDCNR1 | |
| SCHEMBL980297 | 0.70 | PYCR1 (0.43) | LMNAMEN1KMT2AL3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7241775-B2 | Composition, process of making, and medical use of substituted 4-phenyltetrahydroisoquinolines | SANOFI-AVENTIS DEUTSCHLAND GMBH (DE) | 2007-07-10 | — | — | US | disclosed |
| US-20050009863-A1 | Composition, process of making, and medical use of substituted 4-phenyltetrahydroisoquinolines | AVENTIS PHARMA DEUTSCHLAND GMBH (DE) | 2005-01-13 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050009863-A1 | Composition, process of making, and medical use of substituted 4-phenyltetrahydroisoquinolines | CYP27A1, CYP11B2, CYP7A1 | LMNA 906/4885MEN1 3067/4885KMT2A 2273/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.