Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDPK1 | O15530 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 3/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.44 |
| ▸ | GAA | P10253 | 1/20 | 0.44 |
| ▸ | METAP2 | P50579 | 1/20 | 0.42 |
| ▸ | NAPRT | Q6XQN6 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.41 |
| ▸ | CSNK1A1 | P48729 | 2/20 | 0.40 |
| ▸ | DYRK1B | Q9Y463 | 2/20 | 0.40 |
| ▸ | TYRO3 | Q06418 | 1/20 | 0.40 |
| ▸ | TYK2 | P29597 | 1/20 | 0.40 |
| ▸ | PARP1 | P09874 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | IKBKB | O14920 | 2/20 | 0.38 |
| ▸ | CHUK | O15111 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9936824 | 0.80 | GAA (0.68) | PDPK1MAPTKDM4EGAAMETAP2 | |
| SCHEMBL82637 | 0.74 | NAPRT (0.67) | PDPK1MAPTKDM4EGAAMETAP2 | |
| SCHEMBL11628825 | 0.72 | PDPK1 (0.47) | PDPK1MAPTKDM4EGAAMETAP2 | |
| Hydrochloric Acid SCHEMBL30935942 | 0.72 | NAPRT (0.64) | PDPK1MAPTKDM4EGAAMETAP2 | |
| SCHEMBL4783577 | 0.70 | — | — | |
| Anthranilamide SCHEMBL5170575 | 0.69 | AURKA (0.55) | PDPK1MAPTKDM4EGAAMETAP2 | |
| SCHEMBL6630364 | 0.68 | SIRT1 (0.57) | PDPK1MAPTKDM4EGAAMETAP2 | |
| SCHEMBL31120424 | 0.68 | CSNK1A1 (0.54) | PDPK1MAPTKDM4EGAAMETAP2 | |
| SCHEMBL5139889 | 0.68 | CSNK1A1 (0.54) | PDPK1MAPTKDM4EGAAMETAP2 | |
| Formic Acid SCHEMBL30227578 | 0.68 | NAPRT (0.58) | PDPK1MAPTKDM4EGAAMETAP2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 101 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1534278-A4 | NITROSATED PROTON PUMP INHIBITORS, COMPOSITIONS AND METHODS OF USE | NITROMED INC (US) | 2006-09-06 | — | — | EP | claimed |
| JP-2005539013-A | — | — | 2005-12-22 | — | — | JP | claimed |
| EP-1534278-A2 | NITROSATED PROTON PUMP INHIBITORS, COMPOSITIONS AND METHODS OF USE | Nitromed, Inc. (US) | 2005-06-01 | — | — | EP | claimed |
| EP-1154771-A4 | NITROSATED AND NITROSYLATED PROTON PUMP INHIBITORS, COMPOSITIONS AND METHODS OF USE | NITROMED INC (US) | 2005-04-20 | — | — | EP | claimed |
| US-6852739-B1 | Methods using proton pump inhibitors and nitric oxide donors | NITROMED INC. (US) | 2005-02-08 | — | — | US | claimed |
| US-20040266828-A1 | Nitrosated and nitrosylated proton pump inhibitors, compositions and methods of use | NITROMED, INC. (US) | 2004-12-30 | — | — | US | claimed |
| WO-2004012659-A2 | NITROSATED PROTON PUMP INHIBITORS, COMPOSITIONS AND METHODS OF USE | NITROMED, INC. (US) | 2004-02-12 | — | — | WO | claimed |
| US-20040024014-A1 | Nitrosated proton pump inhibitors, compositions and methods of use | NITROMED, INC. (US) | 2004-02-05 | — | — | US | claimed |
| JP-2002537336-A | — | — | 2002-11-05 | — | — | JP | claimed |
| EP-1154771-A1 | NITROSATED AND NITROSYLATED PROTON PUMP INHIBITORS, COMPOSITIONS AND METHODS OF USE | Nitromed, Inc. (US) | 2001-11-21 | — | — | EP | claimed |
| WO-2000050037-A1 | NITROSATED AND NITROSYLATED PROTON PUMP INHIBITORS, COMPOSITIONS AND METHODS OF USE | NITROMED, INC. (US) | 2000-08-31 | — | — | WO | claimed |
| JP-8176113-A | — | — | None | — | — | JP | disclosed |
| US-9085508-B2 | Nitric oxide releasing amino acid ester compound, composition and method of use | ORAL DELIVERY TECHNOLOGY LTD. (US) | 2015-07-21 | — | — | US | disclosed |
| US-8846674-B2 | Nitric oxide enhancing prostaglandin compounds, compositions and methods of use | NICOX, S.A. (FR) | 2014-09-30 | — | — | US | disclosed |
| US-20140057873-A1 | NITRIC OXIDE RELEASING AMINO ACID ESTER COMPOUND, COMPOSITION AND METHOD OF USE | FARBER MICHAEL (US) | 2014-02-27 | — | — | US | disclosed |
| WO-2004024186-A2 | TREATMENT OF CYCLOOXYGENASE-3 MEDIATED DISEASES AND DISORDERS | NITROMED, INC. (US) | 2004-03-25 | — | — | WO | disclosed |
| WO-2004012659-A2 | NITROSATED PROTON PUMP INHIBITORS, COMPOSITIONS AND METHODS OF USE | NITROMED, INC. (US) | 2004-02-12 | — | — | WO | disclosed |
| US-20040024014-A1 | Nitrosated proton pump inhibitors, compositions and methods of use | NITROMED, INC. (US) | 2004-02-05 | — | — | US | disclosed |
| WO-1997032854-A1 | 2-SULFINYLNICOTINAMIDE DERIVATIVES, INTERMEDIATE THEREOF, PROCESS FOR PRODUCING 2-SULFINYLNICOTINAMIDE DERIVATIVES, AND MEDICINAL COMPOSITION CONTAINING THE SAME AS ACTIVE INGREDIENT | DAINIPPON PHARMACEUTICAL CO., LTD. (JP) | 1997-09-12 | — | — | WO | disclosed |
| JP-H08176113-A | 2-SULFINYLNICOTINAMIDE DERIVATIVE, ITS INTERMEDIATE AND CURING AGENT FOR PEPTIC ULCER USING THE DERIVATIVE AS ACTIVE COMPONENT | DAINIPPON PHARMACEUT CO LTD | 1996-07-09 | — | — | JP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040024014-A1 | Nitrosated proton pump inhibitors, compositions and methods of use | NOS1, PTGS1, NOS2 | PDPK1 1483/4885MAPT 4520/4885KDM4E 3767/4885 |
| US-20040266828-A1 | Nitrosated and nitrosylated proton pump inhibitors, compositions and methods of use | NOS2, NOS1, PTGS2 | PDPK1 2330/4885MAPT 4588/4885KDM4E 3035/4885 |
| US-20140057873-A1 | NITRIC OXIDE RELEASING AMINO ACID ESTER COMPOUND, COMPOSITION AND METHOD OF USE | NOS2, NOS3, NOS1 | PDPK1 4589/4885MAPT 3788/4885KDM4E 2671/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.