Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSP90AA1 | P07900 | 7/20 | 0.61 |
| ▸ | HSP90AB1 | P08238 | 2/20 | 0.61 |
| ▸ | IDO1 | P14902 | 3/20 | 0.58 |
| ▸ | PSMB5 | P28074 | 1/20 | 0.58 |
| ▸ | MMP14 | P50281 | 3/20 | 0.56 |
| ▸ | KDM4E | B2RXH2 | 10/20 | 0.49 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.49 |
| ▸ | MPI | P34949 | 1/20 | 0.49 |
| ▸ | CASP6 | P55212 | 2/20 | 0.47 |
| ▸ | NSD2 | O96028 | 1/20 | 0.47 |
| ▸ | G6PD | P11413 | 1/20 | 0.47 |
| ▸ | MEN1 | O00255 | 7/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 7/20 | 0.47 |
| ▸ | HTT | P42858 | 6/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.47 |
| ▸ | LMNA | P02545 | 6/20 | 0.47 |
| ▸ | MAPT | P10636 | 6/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.47 |
| ▸ | TDP1 | Q9NUW8 | 5/20 | 0.47 |
| ▸ | TP53 | P04637 | 4/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9308262 | 0.87 | HSP90AA1 (0.73) | HSP90AA1HSP90AB1IDO1PSMB5MMP14 | |
| SCHEMBL8626641 | 0.85 | HSP90AA1 (0.58) | HSP90AA1HSP90AB1IDO1PSMB5MMP14 | |
| SCHEMBL12192928 | 0.78 | NSD2 (0.68) | HSP90AA1HSP90AB1IDO1PSMB5MMP14 | |
| SCHEMBL1133269 | 0.77 | HSP90AA1 (0.72) | HSP90AA1HSP90AB1IDO1PSMB5MMP14 | |
| SCHEMBL687239 | 0.75 | HSP90AA1 (0.58) | HSP90AA1HSP90AB1IDO1PSMB5MMP14 | |
| SCHEMBL4457883 | 0.75 | HSP90AA1 (0.72) | HSP90AA1HSP90AB1IDO1PSMB5MMP14 | |
| SCHEMBL15339705 | 0.75 | PIK3CD (0.58) | HSP90AA1HSP90AB1IDO1PSMB5MMP14 | |
| SCHEMBL18455869 | 0.75 | HSP90AA1 (0.56) | HSP90AA1HSP90AB1IDO1PSMB5MMP14 | |
| SCHEMBL11973547 | 0.74 | MEN1 (0.51) | HSP90AA1HSP90AB1IDO1PSMB5MMP14 | |
| SCHEMBL688655 | 0.73 | HSP90AA1 (1.00) | HSP90AA1HSP90AB1IDO1PSMB5KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9028562-B2 | Dye composition using a 2-hydroxynaphthalene, (acylamino)phenol or quinoline coupler in a fatty-substance-rich medium, dyeing process and device therefor | L'OREAL (FR) | 2015-05-12 | — | — | US | disclosed |
| US-9028562-B2 | Dye composition using a 2-hydroxynaphthalene, (acylamino)phenol or quinoline coupler in a fatty-substance-rich medium, dyeing process and device therefor | L'OREAL (FR) | 2015-05-12 | — | — | US | disclosed |
| US-20140041133-A1 | DYE COMPOSITION USING A 2-HYDROXYNAPHTHALENE, (ACYLAMINO)PHENOL OR QUINOLINE COUPLER IN A FATTY-SUBSTANCE-RICH MEDIUM, DYEING PROCESS AND DEVICE THEREFOR | L'OREAL (FR) | 2014-02-13 | — | — | US | disclosed |
| US-20140041133-A1 | DYE COMPOSITION USING A 2-HYDROXYNAPHTHALENE, (ACYLAMINO)PHENOL OR QUINOLINE COUPLER IN A FATTY-SUBSTANCE-RICH MEDIUM, DYEING PROCESS AND DEVICE THEREFOR | L'OREAL (FR) | 2014-02-13 | — | — | US | disclosed |
| US-7183291-B2 | Method for the treatment of malaria by the use of primaquine derivative N1-(3-ethylidinotetrahydrofuran-2-one)-N4- (6-methoxy-8-quinolinyl)-1,4-pentanediamine as gametocytocidal agent | COUNCIL OF SCIENTIFIC AND INDUSTRIAL RESEARCH (IN) | 2007-02-27 | — | — | US | disclosed |
| US-7183291-B2 | Method for the treatment of malaria by the use of primaquine derivative N1-(3-ethylidinotetrahydrofuran-2-one)-N4- (6-methoxy-8-quinolinyl)-1,4-pentanediamine as gametocytocidal agent | COUNCIL OF SCIENTIFIC AND INDUSTRIAL RESEARCH (IN) | 2007-02-27 | — | — | US | disclosed |
| US-7183291-B2 | Method for the treatment of malaria by the use of primaquine derivative N1-(3-ethylidinotetrahydrofuran-2-one)-N4- (6-methoxy-8-quinolinyl)-1,4-pentanediamine as gametocytocidal agent | COUNCIL OF SCIENTIFIC AND INDUSTRIAL RESEARCH (IN) | 2007-02-27 | — | — | US | disclosed |
| EP-1055427-B1 | Use of primaquine derivatives for the treatment of malaria | COUNCIL SCIENT IND RES (IN) | 2004-10-13 | — | — | EP | disclosed |
| US-20030199697-A1 | METHOD FOR THE TREATMENT OF MALARIA BY THE USE OF PRIMAQUINE DERIVATIVE N1-(3-ETHYLIDINOTETRAHYDROFURAN-2-ONE) -N 4-(6-METHOXY-8-QUINOLINYL)-1,4-PENTANEDIAMINE AS GAMETOCYTOCIDAL AGENT | COUNCIL OF SCIENTIFIC AND INDUSTRIAL RESEARCH (IN) | 2003-10-23 | — | — | US | disclosed |
| EP-1055427-A1 | Use of primaquine derivatives for the treatment of malaria | Council of Scientific and Industrial Research (IN) | 2000-11-29 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20140041133-A1 | DYE COMPOSITION USING A 2-HYDROXYNAPHTHALENE, (ACYLAMINO)PHENOL OR QUINOLINE COUPLER IN A FATTY-SUBSTANCE-RICH MEDIUM, DYEING PROCESS AND DEVICE THEREFOR | HADHB, HADH, FABP4 | HSP90AA1 2612/4885HSP90AB1 2459/4885IDO1 1046/4885 |
| US-20030199697-A1 | METHOD FOR THE TREATMENT OF MALARIA BY THE USE OF PRIMAQUINE DERIVATIVE N1-(3-ETHYLIDINOTETRAHYDROFURAN-2-ONE) -N 4-(6-METHOXY-8-QUINOLINYL)-1,4-PENTANEDIAMINE AS GAMETOCYTOCIDAL AGENT | QDPR, NQO2, G6PD | HSP90AA1 3530/4885HSP90AB1 4111/4885IDO1 1706/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.