Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP2A6 | P11509 | 3/20 | 0.46 |
| ▸ | CYP1A2 | P05177 | 3/20 | 0.46 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.41 |
| ▸ | CRHR1 | P34998 | 3/20 | 0.38 |
| ▸ | CNR1 | P21554 | 1/20 | 0.36 |
| ▸ | CNR2 | P34972 | 1/20 | 0.36 |
| ▸ | DHFR | P00374 | 1/20 | 0.36 |
| ▸ | HTR1A | P08908 | 1/20 | 0.35 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.35 |
| ▸ | DRD2 | P14416 | 1/20 | 0.35 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.35 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.35 |
| ▸ | HTR1D | P28221 | 1/20 | 0.35 |
| ▸ | HTR1B | P28222 | 1/20 | 0.35 |
| ▸ | HTR2A | P28223 | 1/20 | 0.35 |
| ▸ | HTR2C | P28335 | 1/20 | 0.35 |
| ▸ | HTR1E | P28566 | 1/20 | 0.35 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.35 |
| ▸ | HTR7 | P34969 | 1/20 | 0.35 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10935728 | 0.81 | INSR (0.46) | CYP2A6CYP1A2TDP1DHFRSIGMAR1 | |
| SCHEMBL544100 | 0.81 | ALDH1A1 (0.48) | TDP1CRHR1CNR1CNR2ALDH1A1 | |
| SCHEMBL28594401 | 0.79 | ALDH1A1 (0.34) | CRHR1DHFRALDH1A1TERTKDM4E | |
| SCHEMBL564592 | 0.79 | CHKA (0.34) | CRHR1DHFRTERTCHKA | |
| SCHEMBL564591 | 0.79 | CHKA (0.34) | CRHR1DHFRTERTCHKA | |
| SCHEMBL11375051 | 0.78 | CYP1A2 (0.49) | CYP1A2CRHR1DHFRTERTKDM4E | |
| SCHEMBL7902533 | 0.78 | TDP1 (0.44) | CYP1A2TDP1HTR2BSIGMAR1ALDH1A1 | |
| SCHEMBL12288737 | 0.77 | TERT (0.57) | CYP2A6CYP1A2TDP1ALDH1A1TSHR | |
| SCHEMBL11388779 | 0.75 | CHKA (0.39) | CRHR1DHFRCHKA | |
| SCHEMBL8910940 | 0.75 | DHFR (0.34) | CRHR1DHFRTERTCHKA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 41 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3164158-B1 | COMPOUNDS BINDING TO NEUROPATHOLOGICAL AGGREGATES | YOUSEFI BEHROOZ (DE) | 2020-04-01 | — | — | EP | disclosed |
| US-10421722-B2 | Sulfur-containing compounds targeting vesicular acetylcholine transporter | WASHINGTON UNIVERSITY (US) | 2019-09-24 | — | — | US | disclosed |
| US-10328163-B2 | Compounds binding to neuropathological aggregates | Technische Universität München (DE) | 2019-06-25 | — | — | US | disclosed |
| US-20170355675-A1 | SULFUR-CONTAINING COMPOUNDS TARGETING VESICULAR ACETYLCHOLINE TRANSPORTER | WASHINGTON UNIVERSITY (US) | 2017-12-14 | — | — | US | disclosed |
| US-20170157274-A1 | COMPOUNDS BINDING TO NEUROPATHOLOGICAL AGGREGATES | YOUSEFI, Behrooz H. (DE) | 2017-06-08 | — | — | US | disclosed |
| EP-3164158-A1 | COMPOUNDS BINDING TO NEUROPATHOLOGICAL AGGREGATES | Technische Universität München (DE) | 2017-05-10 | — | — | EP | disclosed |
| WO-2016001422-A1 | COMPOUNDS BINDING TO NEUROPATHOLOGICAL AGGREGATES | Technische Universität München (DE) | 2016-01-07 | — | — | WO | disclosed |
| US-9216974-B2 | Phenoxazine derivatives and methods of use thereof | WASHINGTON UNIVERSITY (US) | 2015-12-22 | — | — | US | disclosed |
| US-9115099-B2 | Phenoxazine derivatives and methods of use thereof | WASHINGTON UNIVERSITY (US) | 2015-08-25 | — | — | US | disclosed |
| US-20150175589-A1 | PHENOXAZINE DERIVATIVES AND METHODS OF USE THEREOF | UNIV WASHINGTON (US) | 2015-06-25 | — | — | US | disclosed |
| US-20080299041-A1 | HETEROCYCLIC INDENE DERIVATIVES AND THEIR RADIOISOTOPE LABELED COMPOUNDS FOR IMAGING BETA-AMYLOID DEPOSITION | SEOUL NATIONAL UNIVERSITY INDUSTRY FOUNDATION (KR) | 2008-12-04 | — | — | US | disclosed |
| WO-2008124812-A1 | PHEN-NAPHTHALENE AND PHEN-QUINOLINE DERIVATIVES AND THEIR USE FOR BINDING AND IMAGING AMYLOID PLAQUES | THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA (US) | 2008-10-16 | — | — | WO | disclosed |
| US-20080233049-A1 | Agents And Methods For Early Diagnosis And Monitoring Of Alzheimer's Disease And Other Neurological Disorders | Ferguson, Ian Andrew (AU) | 2008-09-25 | — | — | US | disclosed |
| US-20080166299-A1 | Prevent accumulation of amyloid deposits | TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA (US) | 2008-07-10 | — | — | US | disclosed |
| WO-2008073350-A2 | ACETYLENE DERIVATIVES AND THEIR USE FOR BINDING AND IMAGING AMYLOID PLAQUES | THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA (US) | 2008-06-19 | — | — | WO | disclosed |
| EP-1893245-A2 | RADIOLABELED-PEGYLATION OF LIGANDS FOR USE AS IMAGING AGENTS | The Trustees of the University of Pennsylvania (US) | 2008-03-05 | — | — | EP | disclosed |
| US-20070122341-A1 | Benzylideneaniline derivatives and their radioisotope labeled compounds for binding and imaging of beta-amyloid plaques | SEOUL NATIONAL UNIVERSITY INDUSTRY FOUNDATION (KR) | 2007-05-31 | — | — | US | disclosed |
| US-20070031328-A1 | Radiolabeled-pegylation of ligands for use as imaging agents | NATIONAL INSTITUTES OF HEALTH - DIRECTOR DEITR | 2007-02-08 | — | — | US | disclosed |
| WO-2007002540-A2 | RADIOLABELED-PEGYLATION OF LIGANDS FOR USE AS IMAGING AGENTS | KUNG HANK F (US) | 2007-01-04 | — | — | WO | disclosed |
| WO-2006070290-A2 | AGENTS AND METHODS FOR EARLY DIAGNOSIS AND MONITORING OF ALZHEIMER'S DISEASE AND OTHER NEUROLOGICAL DISORDERS | FERGUSON IAN A (AU) | 2006-07-06 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (9 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20170157274-A1 | COMPOUNDS BINDING TO NEUROPATHOLOGICAL AGGREGATES | MAPT, APBA1, NEFM | CYP2A6 4879/4885CYP1A2 4869/4885TDP1 553/4885 |
| US-20150175589-A1 | PHENOXAZINE DERIVATIVES AND METHODS OF USE THEREOF | PPOX, CYP4Z1, PRDX2 | CYP2A6 205/4885CYP1A2 12/4885TDP1 2684/4885 |
| US-20080166299-A1 | Prevent accumulation of amyloid deposits | APP, IAPP, TTR | CYP2A6 4741/4885CYP1A2 4576/4885TDP1 400/4885 |
| US-20170355675-A1 | SULFUR-CONTAINING COMPOUNDS TARGETING VESICULAR ACETYLCHOLINE TRANSPORTER | SLC18A3, SLC18A2, SLC7A11 | CYP2A6 2814/4885CYP1A2 3371/4885TDP1 3117/4885 |
| US-10328163-B2 | Compounds binding to neuropathological aggregates | MAPT, APBA1, NEFM | CYP2A6 4879/4885CYP1A2 4869/4885TDP1 553/4885 |
| US-10421722-B2 | Sulfur-containing compounds targeting vesicular acetylcholine transporter | SLC18A3, SLC18A2, SLC7A11 | CYP2A6 2814/4885CYP1A2 3371/4885TDP1 3117/4885 |
| US-20070031328-A1 | Radiolabeled-pegylation of ligands for use as imaging agents | EGFR, LANCL1, FLT1 | CYP2A6 3858/4885CYP1A2 3180/4885TDP1 4236/4885 |
| US-20080299041-A1 | HETEROCYCLIC INDENE DERIVATIVES AND THEIR RADIOISOTOPE LABELED COMPOUNDS FOR IMAGING BETA-AMYLOID DEPOSITION | APP, BACE1, PSEN1 | CYP2A6 3574/4885CYP1A2 579/4885TDP1 1827/4885 |
| US-20070122341-A1 | Benzylideneaniline derivatives and their radioisotope labeled compounds for binding and imaging of beta-amyloid plaques | APP, BACE1, APBA1 | CYP2A6 1888/4885CYP1A2 1016/4885TDP1 3328/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.