SCHEMBL565092

SCHEMBL565092

C=CCNc1ccc(-c2ccc(O)cc2)cc1O

nearest known ligand 0.46

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ALOX5 P09917 1/20 0.46
GABRA1 P14867 1/20 0.40
GABRB2 P47870 1/20 0.40
MAPT P10636 2/20 0.39
NPC1 O15118 1/20 0.39
POLB P06746 1/20 0.39
RAB9A P51151 1/20 0.39
ESR1 P03372 8/20 0.38
MEN1 O00255 2/20 0.38
KMT2A Q03164 2/20 0.38
HCAR3 P49019 1/20 0.38
ESR2 Q92731 6/20 0.37
HSD17B1 P14061 2/20 0.36
HSD17B2 P37059 2/20 0.36
ABL1 P00519 2/20 0.35
ABCB1 P08183 2/20 0.35
BCR P11274 2/20 0.35
PELI1 Q96FA3 1/20 0.35
KDM4E B2RXH2 2/20 0.35
LMNA P02545 1/20 0.35

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL565622 0.93 GABRA1 (0.44) ALOX5GABRA1GABRB2MAPTNPC1
Ether SCHEMBL565802 0.90 ALOX5 (0.38) ALOX5GABRA1GABRB2MAPTNPC1
SCHEMBL564433 0.87 ALOX5 (0.46) ALOX5GABRA1GABRB2MAPTESR1
SCHEMBL9240095 0.86 KDM4E (0.41) MAPTMEN1KMT2AHCAR3KDM4E
SCHEMBL565803 0.86 GAA (0.37) ALOX5GABRA1GABRB2MAPTNPC1
SCHEMBL564768 0.86 HSD17B1 (0.47) GABRA1GABRB2ESR1ESR2HSD17B1
SCHEMBL564675 0.83 GABRA1 (0.37) GABRA1GABRB2MAPTNPC1POLB
Ether SCHEMBL564674 0.83 MAPT (0.39) GABRA1GABRB2MAPTNPC1POLB
SCHEMBL564660 0.79 FFAR4 (0.36) GABRA1GABRB2MAPTNPC1POLB
SCHEMBL566048 0.79 GABRA1 (0.48) ALOX5GABRA1GABRB2MAPTNPC1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-8674029-B2 Method of preparing stabilized polymeric systems using polymeric peroxides Sunocs LLC (US) 2014-03-18 US disclosed
US-20120035307-A1 PROCESS FOR MAKING STABLIZED POLYMERIC SYSTEMS WITH NANOSTRUCTURES SONG CHENGQIAN (US) 2012-02-09 US disclosed
US-20120035315-A1 METHOD OF PREPARING STABLIZED POLYMERIC SYSTEMS USING POLYMERIC PEROXIDES SONG CHENGQIAN (US) 2012-02-09 US disclosed
US-7498467-B2 Antioxidant and bisaminophenol derivative IDEMITSU KOSAN CO., LTD. (JP) 2009-03-03 US disclosed
US-20080161608-A1 ANTIOXIDANT AND BISAMINOPHENOL DERIVATIVE IDEMITSU KOSAN CO., LTD. (JP) 2008-07-03 US disclosed
US-20060208227-A1 Antioxidant and bisaminophenol derivative IDEMITSU LOSAN CO., LTD (JP) 2006-09-21 US disclosed
EP-1612254-A1 ANTIOXIDANT AND BISAMINOPHENOL DERIVATIVE IDEMITSU KOSAN COMPANY LIMITED (JP) 2006-01-04 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20080161608-A1 ANTIOXIDANT AND BISAMINOPHENOL DERIVATIVE CBR1, CBR3, HMOX1 ALOX5 1446/4885GABRA1 1019/4885GABRB2 1083/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.