Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGES | O14684 | 1/20 | 0.53 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.53 |
| ▸ | NR1H4 | Q96RI1 | 2/20 | 0.47 |
| ▸ | GCGR | P47871 | 3/20 | 0.43 |
| ▸ | ADAMTS5 | Q9UNA0 | 2/20 | 0.43 |
| ▸ | ADCY6 | O43306 | 2/20 | 0.43 |
| ▸ | ADCY3 | O60266 | 2/20 | 0.43 |
| ▸ | ADCY9 | O60503 | 2/20 | 0.43 |
| ▸ | ADCY5 | O95622 | 2/20 | 0.43 |
| ▸ | ADCY8 | P40145 | 2/20 | 0.43 |
| ▸ | ADCY7 | P51828 | 2/20 | 0.43 |
| ▸ | ADCY2 | Q08462 | 2/20 | 0.43 |
| ▸ | ADCY1 | Q08828 | 2/20 | 0.43 |
| ▸ | ADCY4 | Q8NFM4 | 2/20 | 0.43 |
| ▸ | ADAMTS4 | O75173 | 1/20 | 0.43 |
| ▸ | MMP12 | P39900 | 2/20 | 0.41 |
| ▸ | MMP2 | P08253 | 1/20 | 0.41 |
| ▸ | MMP8 | P22894 | 1/20 | 0.41 |
| ▸ | EPHX1 | P07099 | 5/20 | 0.40 |
| ▸ | GIPR | P48546 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4369489 | 0.88 | PTGES (0.45) | PTGESALOX5MMP12MMP2MMP8 | |
| SCHEMBL2246642 | 0.87 | MMP12 (0.41) | PTGESALOX5ADAMTS5MMP12MMP2 | |
| SCHEMBL5653525 | 0.84 | SRD5A2 (0.44) | PTGESALOX5MMP12 | |
| SCHEMBL4359337 | 0.83 | MMP12 (0.39) | PTGESALOX5MMP12MMP2MMP8 | |
| SCHEMBL4361259 | 0.82 | TRPM8 (0.53) | MMP12 | |
| SCHEMBL27826145 | 0.82 | TRPM8 (0.46) | — | |
| SCHEMBL4365889 | 0.80 | PTGES (0.45) | PTGESALOX5ADAMTS5ADAMTS4MMP12 | |
| SCHEMBL5653131 | 0.80 | CYP1A2 (0.46) | PTGESALOX5NPSR1 | |
| SCHEMBL2246723 | 0.80 | MMP12 (0.44) | PTGESALOX5MMP12MMP2MMP8 | |
| SCHEMBL5654170 | 0.80 | MMP12 (0.41) | ADAMTS5ADAMTS4MMP12MMP2MMP8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20070043066-A1 | Glutamate aggrecanase inhibitors | WYETH (US) | 2007-02-22 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070043066-A1 | Glutamate aggrecanase inhibitors | ADAMTS5, ADAMTS1, ADAMTS7 | PTGES 1681/4885ALOX5 1774/4885NR1H4 2797/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.