SCHEMBL5653503

SCHEMBL5653503

CN1CCCN(C)P1(=O)c1ccccc1

nearest known ligand 0.36

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
HPGD P15428 3/20 0.36
APOBEC3A P31941 1/20 0.35
APOBEC3G Q9HC16 1/20 0.35
CHRNB2 P17787 1/20 0.33
CHRNB4 P30926 1/20 0.33
CHRNA3 P32297 1/20 0.33
CHRNA7 P36544 1/20 0.33
CHRNA4 P43681 1/20 0.33
RECQL P46063 1/20 0.33
DRD4 P21917 1/20 0.33
OPRM1 P35372 1/20 0.33
MEN1 O00255 1/20 0.33
KMT2A Q03164 1/20 0.33
POLB P06746 1/20 0.32
GAA P10253 1/20 0.32
SLC6A3 Q01959 1/20 0.31
TSHR P16473 1/20 0.31
SMN1; SMN2 Q16637 1/20 0.31
TDP1 Q9NUW8 1/20 0.31
CHKA P35790 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL3797300 0.91 HPGD (0.38) HPGDCHRNB2CHRNB4CHRNA3CHRNA7
SCHEMBL17966099 0.79 RECQL (0.38) APOBEC3AAPOBEC3GCHRNB2CHRNB4CHRNA3
SCHEMBL3798217 0.71 DRD2 (0.41) HPGDDRD4MEN1KMT2AHTT
SCHEMBL11146936 0.70 MEN1 (0.31) MEN1KMT2A
SCHEMBL5655001 0.70 OPRM1 (0.35) CHRNB2CHRNB4CHRNA3CHRNA7CHRNA4
SCHEMBL12353478 0.70 ALDH1A1 (0.34) HPGDMEN1KMT2AGAA
SCHEMBL10530927 0.69 KMT2A (0.38) HPGDRECQLMEN1KMT2APOLB
SCHEMBL3801753 0.68 MEN1 (0.40) HPGDMEN1KMT2ATSHR
SCHEMBL11798652 0.67 HPGD (0.44) HPGDDRD4OPRM1POLBSLC6A3
SCHEMBL29221145 0.64 HPGD (0.42) HPGDDRD4OPRM1POLBSLC6A3

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 45 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-3921349-B1 PHENYL ISOCYANATE CONVERSION PROCESS DOW GLOBAL TECHNOLOGIES LLC (US) 2026-01-14 EP disclosed
US-12030836-B2 Phenyl isocyanate conversion process DOW GLOBAL TECHNOLOGIES LLC (US) 2024-07-09 US disclosed
US-20220106264-A1 PHENYL ISOCYANATE CONVERSION PROCESS DOW GLOBAL TECHNOLOGIES LLC 2022-04-07 US disclosed
EP-3921349-A1 PHENYL ISOCYANATE CONVERSION PROCESS Dow Global Technologies LLC (US) 2021-12-15 EP disclosed
WO-2020163092-A1 PHENYL ISOCYANATE CONVERSION PROCESS DOW GLOBAL TECHNOLOGIES LLC (US) 2020-08-13 WO disclosed
CN-106232667-B Polyiso-ureas 巴斯夫欧洲公司 2020-01-07 CN disclosed
US-10457767-B2 Method of preparing a polycarbodiimide polymer and polycarbodiimide polymer prepared thereby BASF SE (DE) 2019-10-29 US disclosed
EP-2751154-B1 HIGH MOLECULAR WEIGHT POLYCARBODIIMIDE AND METHOD OF PRODUCING SAME BASF SE (DE) 2019-08-21 EP disclosed
EP-3105275-B1 METHOD OF PREPARING A POLYCARBODIIMIDE POLYMER AND POLYCARBODIIMIDE POLYMER PREPARED THEREBY BASF SE (DE) 2019-01-09 EP disclosed
US-20180298557-A1 METHODS FOR TREATING PAPERBOARDS AND PAPER MEDIA, AND ASSOCIATED TREATED PAPERBOARDS AND PAPER MEDIA BASF CORPORATION 2018-10-18 US disclosed
US-6489503-B1 COMPOSITION COMPRISING METHYLENE BIS(PHENYLISOCYANATE) COMPONENT AND POSITIVE AMOUNT OF URETONIMINE, WHICH IS STORAGE STABLE AS LIQUID AT TEMPERATURE OF AT LEAST 30 DEGREES C. BASF CORPORATION 2002-12-03 US disclosed
US-6120699-A CONVERTING A PORTION OF THE 4,4'-MDI INTO A POSITIVE AMOUNT OF A CARBODIIMIDE, THE CARBODIIMIDE SUBSEQUENTLY BEING CONVERTED INTO A POSITIVE AMOUNT OF A URETONIMINE IN THE PRESENCE OF EXCESS 4,4'-MDI BASF CORPORATION (US) 2000-09-19 US disclosed
EP-0989116-A1 Storage stable methylene bis(phenylisocyanate) compositions Basf Corporation (US) 2000-03-29 EP disclosed
US-4937012-A CONTAINING O,P*-AND P,P*-DIPHENYLMETHANE DIISOCYANATES; POLYURETHANE FOAMS BASF CORPORATION (US) 1990-06-26 US disclosed
EP-0308710-A1 Liquid carbodiimide-uretonimine-modified polyphenylene polyisocyanates and polyurethane foams made therefrom BASF Corporation (US) 1989-03-29 EP disclosed
US-4743626-A Liquid carbodiimide-uretonimine modified polymethylene polyphenylene polyisocyanates and polyurethane foams made therefrom BASF CORPORATION (US) 1988-05-10 US disclosed
EP-0193787-A2 Stable 4,4'-diphenylmethane diisocyanates BASF Corporation (US) 1986-09-10 EP disclosed
EP-0189156-A2 Low temperature stable polymethylene polyphenylene polyisocyanates BASF Corporation (US) 1986-07-30 EP disclosed
US-4424288-A Carbodiimide-modified polymethylene polyphenylene polyisocyanates for use in the preparation of polyisocyanurate-polyurethane foams BASF WYANDOTTE CORPORATION (US) 1984-01-03 US disclosed
US-4284730-A Liquid carbodiimide- and uretonimine-isocyanurate-containing polyisocyanate compositions and microcellular foams made therefrom BASF WYANDOTTE CORPORATION (US) 1981-08-18 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-12030836-B2 Phenyl isocyanate conversion process UROD, HPD, UBE2I HPGD 152/4885APOBEC3A 1182/4885APOBEC3G 2007/4885
US-10457767-B2 Method of preparing a polycarbodiimide polymer and polycarbodiimide polymer prepared thereby PAICS, PBRM1, PARG HPGD 1010/4885APOBEC3A 1083/4885APOBEC3G 1653/4885
US-20220106264-A1 PHENYL ISOCYANATE CONVERSION PROCESS UROD, HPD, UBE2I HPGD 152/4885APOBEC3A 1182/4885APOBEC3G 2007/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.