Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MMP12 | P39900 | 2/20 | 0.43 |
| ▸ | TRPM8 | Q7Z2W7 | 3/20 | 0.42 |
| ▸ | MMP2 | P08253 | 2/20 | 0.40 |
| ▸ | MMP8 | P22894 | 1/20 | 0.40 |
| ▸ | MMP13 | P45452 | 1/20 | 0.40 |
| ▸ | FOLH1 | Q04609 | 2/20 | 0.38 |
| ▸ | MDM2 | Q00987 | 1/20 | 0.38 |
| ▸ | PTGES | O14684 | 3/20 | 0.38 |
| ▸ | ALOX5 | P09917 | 3/20 | 0.38 |
| ▸ | HSD17B1 | P14061 | 1/20 | 0.38 |
| ▸ | HSD17B2 | P37059 | 1/20 | 0.38 |
| ▸ | HPGDS | O60760 | 1/20 | 0.37 |
| ▸ | AOC3 | Q16853 | 3/20 | 0.37 |
| ▸ | LTC4S | Q16873 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2246723 | 0.88 | MMP12 (0.44) | MMP12TRPM8MMP2MMP8MMP13 | |
| SCHEMBL4361259 | 0.84 | TRPM8 (0.53) | MMP12TRPM8MDM2HPGDSAOC3 | |
| SCHEMBL4370875 | 0.84 | MMP12 (0.41) | MMP12TRPM8MMP2MMP8MMP13 | |
| SCHEMBL4362591 | 0.84 | HPGDS (0.49) | MMP12TRPM8MMP2MMP8MMP13 | |
| SCHEMBL5650478 | 0.84 | TRPM8 (0.50) | MMP12TRPM8MMP2MMP8MMP13 | |
| SCHEMBL2246642 | 0.83 | MMP12 (0.41) | MMP12MMP2MMP8MMP13PTGES | |
| SCHEMBL27826145 | 0.82 | TRPM8 (0.46) | TRPM8FOLH1 | |
| SCHEMBL4369489 | 0.82 | PTGES (0.45) | MMP12MMP2MMP8MMP13PTGES | |
| SCHEMBL2247349 | 0.81 | HSD17B2 (0.45) | MMP12TRPM8PTGESHSD17B1HSD17B2 | |
| SCHEMBL2244759 | 0.81 | HSD17B2 (0.45) | MMP12TRPM8HSD17B1HSD17B2AOC3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20070043066-A1 | Glutamate aggrecanase inhibitors | WYETH (US) | 2007-02-22 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070043066-A1 | Glutamate aggrecanase inhibitors | ADAMTS5, ADAMTS1, ADAMTS7 | MMP12 54/4885TRPM8 1187/4885MMP2 49/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.