Sugi Predict

Sugi Predict / Compounds / SCHEMBL565623

SCHEMBL565623

SCHEMBL565623

NC(=O)c1c(C(F)(F)F)cc(Cl)nc1Cl

nearest known ligand 0.46

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ POLB P06746 2/20 0.46
▸ ALDH1A1 P00352 3/20 0.39
▸ KDM4E B2RXH2 2/20 0.39
▸ HPGD P15428 2/20 0.39
▸ LMNA P02545 2/20 0.39
▸ TSHR P16473 1/20 0.39
▸ CASP1 P29466 1/20 0.36
▸ MAPK1 P28482 1/20 0.36
▸ SMN1; SMN2 Q16637 1/20 0.36
▸ JUN P05412 1/20 0.35
▸ NFKB1 P19838 1/20 0.35
▸ NFKB2 Q00653 1/20 0.35
▸ RELA Q04206 1/20 0.35
▸ SCN9A Q15858 1/20 0.35
▸ CHEK2 O96017 1/20 0.33
▸ LIMK1 P53667 1/20 0.33
▸ MEN1 O00255 1/20 0.33
▸ KMT2A Q03164 1/20 0.33
▸ XPO1 O14980 1/20 0.33
▸ HTR3E A5X5Y0 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL832709 0.84 ALDH1A1 (0.37) POLBALDH1A1MAPK1SMN1; SMN2JUN
SCHEMBL2090729 0.84 ALDH1A1 (0.49) ALDH1A1MAPK1SMN1; SMN2JUNNFKB1
SCHEMBL8303575 0.83 POLB (0.65) POLBALDH1A1KDM4EHPGDLMNA
SCHEMBL31337111 0.81 CA1 (0.35) POLBALDH1A1MAPK1SMN1; SMN2JUN
SCHEMBL29021390 0.81 CA1 (0.35) POLBALDH1A1MAPK1SMN1; SMN2JUN
SCHEMBL28329012 0.81 KDM4E (0.39) POLBALDH1A1KDM4EHPGDLMNA
SCHEMBL6357726 0.80 NFKB1 (0.40) ALDH1A1MAPK1SMN1; SMN2JUNNFKB1
SCHEMBL6357963 0.79 XPO1 (0.33) ALDH1A1MAPK1SMN1; SMN2JUNNFKB1
SCHEMBL6357967 0.79 JUN (0.33) ALDH1A1MAPK1SMN1; SMN2JUNNFKB1
SCHEMBL6357961 0.79 JUN (0.33) ALDH1A1MAPK1SMN1; SMN2JUNNFKB1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 59 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-118206482-B Synthesis method of 4-trifluoromethyl nicotinamide 山东京博生物科技有限公司 2025-04-25 — — CN claimed
CN-118206482-A Synthesis method of 4-trifluoromethyl nicotinamide 山东京博生物科技有限公司 2024-06-18 — — CN claimed
CN-109232407-A A kind of preparation method and equipment of 4- trifluoromethyl nicotinic acid 衢州凯沃化工有限公司 2019-01-18 — — CN claimed
CN-108586328-A A kind of synthetic method of 4- trifluoromethyl nicotinic acids 福州华博立乐新材料科技有限公司 2018-09-28 — — CN claimed
CN-108530352-A A kind of synthetic method of 2,6- dichlor-4-trifluoromethyls niacinamide 福州兴创云达新材料科技有限公司 2018-09-14 — — CN claimed
CN-118206482-B Synthesis method of 4-trifluoromethyl nicotinamide 山东京博生物科技有限公司 2025-04-25 — — CN disclosed
CN-118206482-B Synthesis method of 4-trifluoromethyl nicotinamide 山东京博生物科技有限公司 2025-04-25 — — CN disclosed
CN-118206482-A Synthesis method of 4-trifluoromethyl nicotinamide 山东京博生物科技有限公司 2024-06-18 — — CN disclosed
CN-118206482-A Synthesis method of 4-trifluoromethyl nicotinamide 山东京博生物科技有限公司 2024-06-18 — — CN disclosed
CN-117756704-A Intermediate compound and preparation method thereof, and preparation method of 4-trifluoromethyl nicotinic acid and derivative thereof 帕潘纳(北京)科技有限公司 2024-03-26 — — CN disclosed
CN-113816901-B Synthesis method of 4-trifluoromethyl nicotinamide 淮北龙溪生物科技有限公司 2023-08-15 — — CN disclosed
CN-113816901-A Synthetic method of 4-trifluoromethyl nicotinamide 淮北龙溪生物科技有限公司 2021-12-21 — — CN disclosed
US-20030232818-A1 Antibacterial compounds ABBVIE INC. 2003-12-18 — — US disclosed
CN-1419542-A Heterocyclic acylsulfimide compounds, process for their preparation, compositions containing them and their use as pesticides BAYER CROSCIENCE GMBH (DE) 2003-05-21 — — CN disclosed
EP-1274683-A2 HETEROCYCLIC ACYLSULFIMIDES, A METHOD FOR THEIR PRODUCTION, AGENTS CONTAINING THE SAME AND THEIR USE AS PESTICIDES Bayer CropScience GmbH (DE) 2003-01-15 — — EP disclosed
US-20020032328-A1 Heterocyclic acylsulfimides, processes for their preparation, compositions comprising them and their use as pesticides AVENTIS CROPSCIENCE GMBH (DE) 2002-03-14 — — US disclosed
WO-2001070692-A2 HETEROCYCLIC ACYLSULFIMIDES, A METHOD FOR THEIR PRODUCTION, AGENTS CONTAINING THE SAME AND THEIR USE AS PESTICIDES BAYER CROPSCIENCE GMBH (DE) 2001-09-27 — — WO disclosed
EP-0580374-B1 Pyridine amides and their salts, processes for their production and pesticidal compositions containing them ISHIHARA SANGYO KAISHA (JP) 1996-01-03 — — EP disclosed
US-5360806-A Insecticides ISHIHARA SANGYO KAISHA LTD. (JP) 1994-11-01 — — US disclosed
EP-0580374-A1 Pyridine amides and their salts, processes for their production and pesticidal compositions containing them ISHIHARA SANGYO KAISHA, LTD. (JP) 1994-01-26 — — EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20030232818-A1 Antibacterial compounds PGLS, UGT1A1, CASP1 POLB 234/4885ALDH1A1 292/4885KDM4E 4269/4885
US-20020032328-A1 Heterocyclic acylsulfimides, processes for their preparation, compositions comprising them and their use as pesticides DDT, PTMS, TMT1A POLB 4249/4885ALDH1A1 768/4885KDM4E 1334/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.