SCHEMBL565677

SCHEMBL565677

O=C(O)CN(CCNS(=O)(=O)c1ccc2ccccc2c1)CC(=O)O

nearest known ligand 0.66

Predicted protein targets (top 13)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 5/20 0.66
KAT6A Q92794 3/20 0.52
LMNA P02545 1/20 0.51
GAA P10253 1/20 0.51
SMN1; SMN2 Q16637 1/20 0.51
CYP19A1 P11511 1/20 0.50
TPSAB1 Q15661 1/20 0.50
NPY1R P25929 1/20 0.49
NPY5R Q15761 1/20 0.49
MEN1 O00255 1/20 0.48
KMT2A Q03164 1/20 0.48
CTSS P25774 1/20 0.48
HTR7 P34969 1/20 0.47

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL1082840 0.84 ALDH1A1 (0.56) ALDH1A1LMNAGAASMN1; SMN2
SCHEMBL6792532 0.82 ALDH1A1 (0.84) ALDH1A1KAT6ALMNAGAASMN1; SMN2
SCHEMBL25759592 0.80 ALDH1A1 (0.64) ALDH1A1LMNAGAASMN1; SMN2CYP19A1
SCHEMBL30390015 0.80 ALDH1A1 (0.64) ALDH1A1LMNAGAASMN1; SMN2CYP19A1
Edetic Acid SCHEMBL20659741 0.80 SNCA (0.49) ALDH1A1KAT6ALMNA
SCHEMBL6792727 0.80 ALDH1A1 (1.00) ALDH1A1KAT6ALMNAGAANPY1R
SCHEMBL29141944 0.79 TPSAB1 (0.61) ALDH1A1LMNAGAASMN1; SMN2CYP19A1
SCHEMBL8783320 0.79 ALDH1A1 (0.59) ALDH1A1KAT6ALMNAGAASMN1; SMN2
SCHEMBL6438335 0.79 ALDH1A1 (0.69) ALDH1A1KAT6AGAACYP19A1KMT2A
SCHEMBL566005 0.78 TSHR (0.61) ALDH1A1LMNAGAAMEN1KMT2A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 27 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-11517529-B2 Orally bioavailable lipid-based constructs SDG, INC. (US) 2022-12-06 US disclosed
US-20200405638-A1 ORALLY BIOAVAILABLE LIPID-BASED CONSTRUCTS SDG INC (US) 2020-12-31 US disclosed
US-20200261363-A1 LIPID CONSTRUCT FOR DELIVERY OF INSULIN TO A MAMMAL SDG INC (US) 2020-08-20 US disclosed
US-10568835-B2 Orally bioavailable lipid-based constructs SDG, INC. (US) 2020-02-25 US disclosed
US-10004686-B2 Lipid construct for delivery of insulin to a mammal SDG, INC. (US) 2018-06-26 US disclosed
US-9943602-B2 Orally bioavailable lipid-based constructs SDG, INC. (US) 2018-04-17 US disclosed
US-9145453-B2 Orally bioavailable lipid-based constructs SDG, INC. (US) 2015-09-29 US disclosed
US-9034372-B2 Lipid construct for delivery of insulin to a mammal SDG, INC. (US) 2015-05-19 US disclosed
US-8962015-B2 Orally bioavailable lipid-based constructs SDG, INC. (US) 2015-02-24 US disclosed
US-20150031608-A1 LIPID CONSTRUCT FOR DELIVERY OF INSULIN TO A MAMMAL SDG, INC. 2015-01-29 US disclosed
US-20110135725-A1 Lipid Construct for Delivery of Insulin to a Mammal SDG, INC. (US) 2011-06-09 US disclosed
US-7871641-B2 Hepatocyte-targeting vehicle for delivery of glargine insulin to a mammal SDG, INC. (US) 2011-01-18 US disclosed
US-7858116-B2 Hepatocyte delivery vehicle for delivery of a combination of recombinant human regular insulin and recombinant human insulin isophane to a mammal SDG, INC. (US) 2010-12-28 US disclosed
US-20100310599-A1 Orally Bioavailable Lipid-Based Constructs SDG, INC. 2010-12-09 US disclosed
US-20100247625-A1 Orally Bioavailable Lipid-Based Constructs SDG, INC. 2010-09-30 US disclosed
US-20100129428-A1 SUPRA MOLECULAR CONSTRUCT FOR DELIVERY OF INTERFERON TO A MAMMAL SDG, INC. 2010-05-27 US disclosed
US-20100080773-A1 Orally Bioavailable Lipid-Based Constructs SDG, INC. 2010-04-01 US disclosed
US-20090087479-A1 Orally bioavailable lipid-based constructs SDG, INC. ( AN OHIO CORPORATION) (US) 2009-04-02 US disclosed
US-20060222698-A1 Hepatocyte delivery vehicle for delivery of glargine insulin to a mammal SDG, INC. 2006-10-05 US disclosed
US-20060222697-A1 Hepatocyte delivery vehicle for delivery of a combination of recombinant human regular insulin and recombinant human insulin isophane to a mammal SDG, INC. 2006-10-05 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (14 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-10568835-B2 Orally bioavailable lipid-based constructs FABP2, FABP1, FABP6 ALDH1A1 2309/4885KAT6A 3709/4885LMNA 1568/4885
US-20100080773-A1 Orally Bioavailable Lipid-Based Constructs FABP2, FABP1, LIPC ALDH1A1 3404/4885KAT6A 4438/4885LMNA 1398/4885
US-20100129428-A1 SUPRA MOLECULAR CONSTRUCT FOR DELIVERY OF INTERFERON TO A MAMMAL HAVCR2, IFNAR1, IFNG ALDH1A1 3395/4885KAT6A 2453/4885LMNA 2232/4885
US-10004686-B2 Lipid construct for delivery of insulin to a mammal INSR, IAPP, GPR119 ALDH1A1 4198/4885KAT6A 1913/4885LMNA 1192/4885
US-20100310599-A1 Orally Bioavailable Lipid-Based Constructs FABP2, LIPC, FABP6 ALDH1A1 1477/4885KAT6A 852/4885LMNA 1669/4885
US-11517529-B2 Orally bioavailable lipid-based constructs FABP2, FABP1, FABP6 ALDH1A1 2309/4885KAT6A 3709/4885LMNA 1568/4885
US-20200405638-A1 ORALLY BIOAVAILABLE LIPID-BASED CONSTRUCTS FABP2, FABP1, FABP6 ALDH1A1 2309/4885KAT6A 3709/4885LMNA 1568/4885
US-20060222698-A1 Hepatocyte delivery vehicle for delivery of glargine insulin to a mammal INSR, GPR119, GCG ALDH1A1 4129/4885KAT6A 376/4885LMNA 1121/4885
US-20090087479-A1 Orally bioavailable lipid-based constructs FABP2, FABP1, FABP6 ALDH1A1 3085/4885KAT6A 4262/4885LMNA 1949/4885
US-20200261363-A1 LIPID CONSTRUCT FOR DELIVERY OF INSULIN TO A MAMMAL INSR, IAPP, GPR119 ALDH1A1 4198/4885KAT6A 1913/4885LMNA 1192/4885
US-20110135725-A1 Lipid Construct for Delivery of Insulin to a Mammal INSR, IAPP, GPR119 ALDH1A1 4198/4885KAT6A 1913/4885LMNA 1192/4885
US-20100247625-A1 Orally Bioavailable Lipid-Based Constructs FABP2, LIPC, FABP6 ALDH1A1 1477/4885KAT6A 852/4885LMNA 1669/4885
US-20150031608-A1 LIPID CONSTRUCT FOR DELIVERY OF INSULIN TO A MAMMAL INSR, IAPP, GPR119 ALDH1A1 4198/4885KAT6A 1913/4885LMNA 1192/4885
US-20060222697-A1 Hepatocyte delivery vehicle for delivery of a combination of recombinant human regular insulin and recombinant human insulin isophane to a mammal INSR, INSRR, IAPP ALDH1A1 4252/4885KAT6A 2025/4885LMNA 1540/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.