Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LTA4H | P09960 | 8/20 | 0.51 |
| ▸ | SIGMAR1 | Q99720 | 3/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.47 |
| ▸ | CYP4A11 | Q02928 | 2/20 | 0.47 |
| ▸ | LOXL2 | Q9Y4K0 | 1/20 | 0.46 |
| ▸ | MEN1 | O00255 | 1/20 | 0.46 |
| ▸ | LMNA | P02545 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.46 |
| ▸ | CYP4F2 | P78329 | 1/20 | 0.46 |
| ▸ | TMEM97 | Q5BJF2 | 2/20 | 0.45 |
| ▸ | NPC1 | O15118 | 1/20 | 0.45 |
| ▸ | GAA | P10253 | 1/20 | 0.45 |
| ▸ | HPGD | P15428 | 1/20 | 0.45 |
| ▸ | TSHR | P16473 | 1/20 | 0.45 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.45 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL846524 | 0.82 | SIGMAR1 (0.51) | SIGMAR1KDM4EALDH1A1SMN1; SMN2CYP4A11 | |
| SCHEMBL5776546 | 0.81 | CYP4A11 (0.57) | SIGMAR1KDM4EALDH1A1SMN1; SMN2CYP4A11 | |
| SCHEMBL22815180 | 0.81 | LTA4H (0.48) | LTA4HKDM4EALDH1A1MEN1KMT2A | |
| SCHEMBL27220639 | 0.81 | LOXL2 (0.56) | KDM4EALDH1A1SMN1; SMN2CYP4A11LOXL2 | |
| SCHEMBL5775042 | 0.80 | LOXL2 (0.56) | KDM4EALDH1A1SMN1; SMN2CYP4A11LOXL2 | |
| SCHEMBL1638297 | 0.80 | SIGMAR1 (0.47) | SIGMAR1KDM4EALDH1A1SMN1; SMN2CYP4A11 | |
| SCHEMBL13052122 | 0.79 | ACHE (0.66) | KDM4EALDH1A1SMN1; SMN2LOXL2MEN1 | |
| SCHEMBL9826363 | 0.79 | SMN1; SMN2 (0.58) | SIGMAR1KDM4EALDH1A1SMN1; SMN2CYP4A11 | |
| SCHEMBL5312334 | 0.79 | LTA4H (0.85) | LTA4H | |
| SCHEMBL3036189 | 0.78 | PRMT1 (0.52) | SIGMAR1KDM4EALDH1A1SMN1; SMN2CYP4A11 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20070155727-A1 | Amide inhibitors of leukotriene A4 hydrolase | SCHERING AKTIENGESSELLSCHAFT (DE) | 2007-07-05 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070155727-A1 | Amide inhibitors of leukotriene A4 hydrolase | LTA4H, LTB4R, LTC4S | LTA4H 1/4885SIGMAR1 353/4885KDM4E 1019/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.