Known targets — ChEMBL curated mechanism
ACEADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ATP4AATP4BAXLBTKCACNA1CCACNA1DCACNA1FCACNA1SCCR5CHRM2CHRM3CPT1BCPT2DPP4DRD1DRD2EGFRERBB2ERBB4FLT3HRH1HRH3HTR1AHTR2AHTR2BHTR2CHTR4JAK1JAK2JAK3KCNH2KMT2AMAP2K1MAP2K2MEN1MLNRMPLMTORPPIK3CAPIK3CBPIK3CDPIK3CGPIK3R1PIK3R2PIK3R3PIK3R5PLK4PPARGRENS1PR1SLC6A2SLC6A3SLC6A4SMOTYK2atpAatpBatpCatpDatpEatpFatpFHatpGpol
The experimentally established mechanism targets of Fumaric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2A known ✓ | P28223 | 4/20 | 0.49 |
| ▸ | HTR1A known ✓ | P08908 | 2/20 | 0.49 |
| ▸ | HTR2C known ✓ | P28335 | 3/20 | 0.41 |
| ▸ | SLC6A4 known ✓ | P31645 | 1/20 | 0.39 |
| ▸ | DRD2 known ✓ | P14416 | 1/20 | 0.39 |
| ▸ | HTR2B known ✓ | P41595 | 1/20 | 0.39 |
| ▸ | TMEM97 | Q5BJF2 | 1/20 | 0.49 |
| ▸ | HTR7 | P34969 | 2/20 | 0.41 |
| ▸ | HTR6 | P50406 | 2/20 | 0.41 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Fumaric Acid SCHEMBL5657213 | 1.00 | HTR2A (0.49) | HTR2AHTR1ATMEM97HTR2CHTR7 | |
| Fumaric Acid SCHEMBL5656376 | 0.93 | HTR2A (0.52) | HTR2AHTR1ATMEM97HTR2CHTR7 | |
| Fumaric Acid SCHEMBL5656373 | 0.93 | HTR2A (0.52) | HTR2AHTR1ATMEM97HTR2CHTR7 | |
| Fumaric Acid SCHEMBL5660934 | 0.90 | HTR2A (0.49) | HTR2AHTR1ATMEM97HTR2CHTR7 | |
| Fumaric Acid SCHEMBL5660938 | 0.90 | HTR2A (0.49) | HTR2AHTR1ATMEM97HTR2CHTR7 | |
| Fumaric Acid SCHEMBL5660135 | 0.87 | HTR1A (0.49) | HTR2AHTR1ATMEM97HTR2CSLC6A4 | |
| Fumaric Acid SCHEMBL5656452 | 0.87 | HTR2A (0.47) | HTR2AHTR1ATMEM97HTR2CHTR7 | |
| Fumaric Acid SCHEMBL5660130 | 0.87 | HTR1A (0.49) | HTR2AHTR1ATMEM97HTR2CSLC6A4 | |
| Fumaric Acid SCHEMBL5656449 | 0.87 | HTR2A (0.47) | HTR2AHTR1ATMEM97HTR2CHTR7 | |
| Fumaric Acid SCHEMBL5248149 | 0.83 | HTR2A (0.54) | HTR2AHTR1ATMEM97HTR2CHTR7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7166617-B2 | Cyclic amide derivatives | MITSUBISHI PHARMA CORPORATION (JP) | 2007-01-23 | — | — | US | disclosed |
| US-20030212094-A1 | Novel cyclic amide derivatives | MITSUBISHI PHARMA CORPORATION (JP) | 2003-11-13 | — | — | US | disclosed |
| EP-1260512-A1 | NOVEL CYCLIC AMIDE DERIVATIVES | Mitsubishi Pharma Corporation (JP) | 2002-11-27 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20030212094-A1 | Novel cyclic amide derivatives | SIGMAR1, OPRM1, OPRD1 | HTR2A 153/4885HTR1A 79/4885HTR2C 78/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.