SCHEMBL5665177

SCHEMBL5665177

NC([C]=O)CC1CCC(O)CC1

nearest known ligand 0.34

Predicted protein targets (top 3)

geneUniProtsupporting neighboursconfidence
ANPEP P15144 2/20 0.34
ENPEP Q07075 2/20 0.34
SHBG P04278 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8190656 1.00 ANPEP (0.34) ANPEPENPEPSHBG
SCHEMBL7608856 0.89
SCHEMBL8943205 0.81 CPB2 (0.36) ANPEPENPEP
SCHEMBL2640244 0.81 CPB2 (0.36) ANPEPENPEP
SCHEMBL7375737 0.80 ALOX5 (0.34)
SCHEMBL7375837 0.80
SCHEMBL7418539 0.78 METAP1 (0.37)
SCHEMBL1449256 0.78 METAP1 (0.37)
SCHEMBL3504941 0.78 METAP1 (0.37)
SCHEMBL10583764 0.75 CPN1 (0.42) ANPEP

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 22 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-5449612-A Process for identifying candida by means of chromogenic substances SERBIO (FR) 1995-09-12 US claimed
EP-0280610-B1 DIPEPTIDES, PREPARATION PROCESS AND USE IN DOSING PROTEASES SERBIO (FR) 1992-10-21 EP claimed
EP-1545572-A4 CONJUGATES ACTIVATED BY CELL SURFACE PROTEASES AND THERAPEUTIC USES THEREOF DENDREON CORP (US) 2006-04-12 EP disclosed
EP-1545572-A2 CONJUGATES ACTIVATED BY CELL SURFACE PROTEASES AND THERAPEUTIC USES THEREOF Dendreon Corporation (US) 2005-06-29 EP disclosed
US-20040001801-A1 Conjugates activated by cell surface proteases and therapeutic uses thereof CORVAS INTERNATIONAL, INC. 2004-01-01 US disclosed
WO-2002095007-A2 CONJUGATES ACTIVATED BY CELL SURFACE PROTEASES AND THERAPEUTIC USES THEREOF DENDREON SAN DIEGO LLC (US) 2002-11-28 WO disclosed
US-6121239-A SPECIFIED TRI- AND TETRA-PEPTIDES SERBIO (FR) 2000-09-19 US disclosed
EP-0456567-B1 Procedure to determine a plasminogen activator and its inhibitor STAGO DIAGNOSTICA (FR) 1998-01-07 EP disclosed
EP-0476107-B1 PROCESS FOR IDENTIFYING CANDIDA ALBICANS BY MEANS OF CHROMOGENIC SUBSTANCES STAGO DIAGNOSTICA (FR) 1996-06-19 EP disclosed
US-5472851-A Converting plasminogen to plasmin and the assaying plasmin resulting from said conversion; inhibiting plsma proteins alpha2-antiplsmin and alpha2-macroglobulin by contact with metalloproteinase SERBIO (FR) 1995-12-05 US disclosed
US-5449612-A Process for identifying candida by means of chromogenic substances SERBIO (FR) 1995-09-12 US disclosed
US-5225532-A SYMMETRICAL BIPEPTIDES CONTAINING A POLYALKYLENE GLYCOL RESIDUE, METHOD OF PREPARATION AND USE IN THE ASSAY OF PROTEASES SERBIO (FR) 1993-07-06 US disclosed
EP-0280610-B1 DIPEPTIDES, PREPARATION PROCESS AND USE IN DOSING PROTEASES SERBIO (FR) 1992-10-21 EP disclosed
EP-0472671-A1 PEPTIDE SUBSTRATES FOR Xa FACTOR IDENTIFICATION. SERBIO (FR) 1992-03-04 EP disclosed
EP-0456567-A1 Procedure to determine a plasminogen activator and its inhibitor DIAGNOSTICA STAGO (société anonyme) (FR) 1991-11-13 EP disclosed
WO-1991014787-A1 PROCESS FOR IDENTIFYING CANDIDA BY MEANS OF CHROMOGENIC SUBSTANCES SERBIO (FR) 1991-10-03 WO disclosed
WO-1991012338-A1 PEPTIDE SUBSTRATES FOR Xa FACTOR IDENTIFICATION SERBIO (FR) 1991-08-22 WO disclosed
WO-1991012263-A1 SYMMETRICAL BIPEPTIDES INCLUDING A POLYALKYLENE-GYLCOL GROUP, METHOD OF PREPARATION AND USE IN PROTEASE DETERMINATION SERBIO (FR) 1991-08-22 WO disclosed
EP-0280610-A1 Dipeptides, preparation process and use in dosing proteases SERBIO (FR) 1988-08-31 EP disclosed
US-4598043-A Method for quantitatively assaying blood coagulation factor XII in human plasma PENTAPHARM AG (CH) 1986-07-01 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20040001801-A1 Conjugates activated by cell surface proteases and therapeutic uses thereof PLAUR, ENPEP, MASP2 ANPEP 54/4885ENPEP 2/4885SHBG 2312/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.