Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH3 | Q9Y5N1 | 4/20 | 0.40 |
| ▸ | HRH4 | Q9H3N8 | 5/20 | 0.38 |
| ▸ | AOC3 | Q16853 | 2/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.37 |
| ▸ | NPC1 | O15118 | 1/20 | 0.35 |
| ▸ | RAB9A | P51151 | 1/20 | 0.35 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.34 |
| ▸ | MAPT | P10636 | 2/20 | 0.34 |
| ▸ | LOXL2 | Q9Y4K0 | 1/20 | 0.34 |
| ▸ | FLT3 | P36888 | 1/20 | 0.34 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.34 |
| ▸ | AKR1C3 | P42330 | 2/20 | 0.34 |
| ▸ | DAO | P14920 | 1/20 | 0.33 |
| ▸ | HPGD | P15428 | 1/20 | 0.33 |
| ▸ | SRD5A2 | P31213 | 1/20 | 0.33 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4817715 | 0.84 | HRH3 (0.42) | HRH3HRH4AOC3ALDH1A1NPC1 | |
| SCHEMBL27541527 | 0.79 | HRH3 (0.44) | HRH3HRH4AOC3ALDH1A1NPC1 | |
| SCHEMBL30613385 | 0.73 | AOC3 (0.38) | HRH3HRH4AOC3ALDH1A1NPC1 | |
| SCHEMBL8087823 | 0.73 | HRH3 (0.50) | HRH3HRH4AOC3ALDH1A1NPC1 | |
| SCHEMBL29684111 | 0.71 | HRH3 (0.49) | HRH3HRH4AOC3NPC1RAB9A | |
| SCHEMBL2940750 | 0.71 | HRH3 (0.49) | HRH3HRH4AOC3NPC1RAB9A | |
| SCHEMBL5240716 | 0.71 | ALDH1A1 (0.43) | HRH3HRH4AOC3ALDH1A1NPC1 | |
| SCHEMBL38661680 | 0.70 | HRH3 (0.53) | HRH3HRH4AOC3ALDH1A1KDM4E | |
| SCHEMBL92726 | 0.70 | HRH3 (0.53) | HRH3HRH4AOC3ALDH1A1KDM4E | |
| Hydrochloric Acid SCHEMBL3714613 | 0.70 | HRH3 (0.47) | HRH3HRH4AOC3NPC1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 59 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0003200-B1 | TETRAHYDROPYRIDINYL INDOLE DERIVATIVES AND THEIR SALTS FOR USE IN A METHOD FOR THERAPEUTIC TREATMENT OF THE HUMAN OR ANIMAL BODY AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | ROUSSEL-UCLAF (FR) | 1986-08-13 | — | — | EP | claimed |
| EP-0022705-B1 | DERIVATIVES OF TETRAHYDROPYRIDINYL-INDOL AND THEIR SALTS, THEIR PREPARATION, THEIR APPLICATION AS MEDICINES, AND COMPOSITIONS CONTAINING THEM | ROUSSEL-UCLAF (FR) | 1983-04-06 | — | — | EP | claimed |
| EP-0003199-B1 | TETRAHYDROPYRIDINYL INDOLE DERIVATIVES AND THEIR SALTS, PROCESS FOR THEIR PREPARATION, THEIR USE AS MEDICINES AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | ROUSSEL-UCLAF (FR) | 1981-11-11 | — | — | EP | claimed |
| EP-0022705-A1 | Derivatives of tetrahydropyridinyl-indol and their salts, their preparation, their application as medicines, and compositions containing them | ROUSSEL-UCLAF (FR) | 1981-01-21 | — | — | EP | claimed |
| EP-0003199-A2 | Tetrahydropyridinyl indole derivatives and their salts, process for their preparation, their use as medicines and pharmaceutical compositions containing them | ROUSSEL-UCLAF (FR) | 1979-07-25 | — | — | EP | claimed |
| EP-0003200-A2 | Tetrahydropyridinyl indole derivatives and their salts for use in a method for therapeutic treatment of the human or animal body and pharmaceutical compositions containing them | ROUSSEL-UCLAF (FR) | 1979-07-25 | — | — | EP | claimed |
| CN-113861193-A | Method for preparing indolopyridyl tetralone and derivatives thereof by photoinitiated free radical series reaction and products | 西南大学 | 2021-12-31 | — | — | CN | disclosed |
| CN-113861193-A | Method for preparing indolopyridyl tetralone and derivatives thereof by photoinitiated free radical series reaction and products | 西南大学 | 2021-12-31 | — | — | CN | disclosed |
| CN-101084225-B | Isoxazoline-indole derivatives with an improved antipsychotic and anxiolytic a ivity | JANSSEN PHARMACEUTICA NV | 2011-03-02 | — | — | CN | disclosed |
| CN-101084225-A | Isoxazoline-indole derivatives with an improved antipsychotic and anxiolytic a ivity | JANSSEN PHARMACEUTICA NV (BE) | 2007-12-05 | — | — | CN | disclosed |
| US-7235569-B2 | Piperidinyl indole and tetrohydropyridinyl indole derivatives and method of their use | WYETH (US) | 2007-06-26 | — | — | US | disclosed |
| US-20050004162-A1 | Piperidinyl indole and tetrohydropyridinyl indole derivatives and method of their use | WYETH | 2005-01-06 | — | — | US | disclosed |
| US-20020128272-A1 | 4,5,6, and 7-indole and indoline derivatives, their preparation and use | H. LUNDBECK A/S (DK) | 2002-09-12 | — | — | US | disclosed |
| EP-0022705-A1 | Derivatives of tetrahydropyridinyl-indol and their salts, their preparation, their application as medicines, and compositions containing them | ROUSSEL-UCLAF (FR) | 1981-01-21 | — | — | EP | disclosed |
| EP-0003199-A2 | Tetrahydropyridinyl indole derivatives and their salts, process for their preparation, their use as medicines and pharmaceutical compositions containing them | ROUSSEL-UCLAF (FR) | 1979-07-25 | — | — | EP | disclosed |
| EP-0003199-A2 | Tetrahydropyridinyl indole derivatives and their salts, process for their preparation, their use as medicines and pharmaceutical compositions containing them | ROUSSEL-UCLAF (FR) | 1979-07-25 | — | — | EP | disclosed |
| EP-0003199-A2 | Tetrahydropyridinyl indole derivatives and their salts, process for their preparation, their use as medicines and pharmaceutical compositions containing them | ROUSSEL-UCLAF (FR) | 1979-07-25 | — | — | EP | disclosed |
| EP-0003200-A2 | Tetrahydropyridinyl indole derivatives and their salts for use in a method for therapeutic treatment of the human or animal body and pharmaceutical compositions containing them | ROUSSEL-UCLAF (FR) | 1979-07-25 | — | — | EP | disclosed |
| EP-0003200-A2 | Tetrahydropyridinyl indole derivatives and their salts for use in a method for therapeutic treatment of the human or animal body and pharmaceutical compositions containing them | ROUSSEL-UCLAF (FR) | 1979-07-25 | — | — | EP | disclosed |
| EP-0003200-A2 | Tetrahydropyridinyl indole derivatives and their salts for use in a method for therapeutic treatment of the human or animal body and pharmaceutical compositions containing them | ROUSSEL-UCLAF (FR) | 1979-07-25 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20020128272-A1 | 4,5,6, and 7-indole and indoline derivatives, their preparation and use | HTR2C, HTR1A, HTR7 | HRH3 404/4885HRH4 286/4885AOC3 841/4885 |
| US-20050004162-A1 | Piperidinyl indole and tetrohydropyridinyl indole derivatives and method of their use | TPH1, TPH2, HTR4 | HRH3 359/4885HRH4 424/4885AOC3 2350/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.