Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAOB | P27338 | 1/20 | 0.43 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.38 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.38 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.36 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.36 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.36 |
| ▸ | PRMT1 | Q99873 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.35 |
| ▸ | TP53 | P04637 | 1/20 | 0.34 |
| ▸ | CA1 | P00915 | 1/20 | 0.34 |
| ▸ | CA2 | P00918 | 1/20 | 0.34 |
| ▸ | ARG2 | P78540 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | NPC1 | O15118 | 1/20 | 0.33 |
| ▸ | RAB9A | P51151 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5671669 | 0.81 | GPR52 (0.37) | SLC6A2TAAR1LMNATDP1KMT2A | |
| SCHEMBL8552112 | 0.77 | MAOB (0.48) | MAOBTDP1TP53CA1CA2 | |
| SCHEMBL8552111 | 0.77 | MAOB (0.48) | MAOBTDP1TP53CA1CA2 | |
| SCHEMBL5671609 | 0.77 | L3MBTL1 (0.41) | MAOB | |
| SCHEMBL5038975 | 0.77 | TSHR (0.45) | CA1CA2KMT2AMEN1ALDH1A1 | |
| SCHEMBL5673067 | 0.75 | SIGMAR1 (0.42) | — | |
| SCHEMBL29185811 | 0.72 | MAOB (0.43) | MAOBSLC6A2TAAR1CYP2D6TP53 | |
| SCHEMBL5039037 | 0.72 | AOC3 (0.46) | MAOBTAAR1CYP2D6LMNAALDH1A1 | |
| SCHEMBL9631441 | 0.72 | HTR2A (0.41) | MAOBTDP1KMT2AMEN1NPC1 | |
| SCHEMBL16329903 | 0.72 | MAOB (0.52) | MAOBSLC6A2TAAR1CYP3A4TDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7115666-B2 | Nitrone compounds, pharmaceutical compositions containing the same and methods for treating inflammation and neuropathic pain | RENOVIS, INC. (US) | 2006-10-03 | — | — | US | disclosed |
| EP-1578717-A4 | NITRONE COMPOUNDS, PHARMACEUTICAL COMPOSITIONS CONTAINING THE SAME AND METHODS FOR TREATING INFLAMMATION AND NEUROPATHIC PAIN | RENOVIS INC (US) | 2006-08-09 | — | — | EP | disclosed |
| US-20060100289-A1 | Nitrone compounds, pharmaceutical compositions containing the same and methods for treating inflammation and neuropathic pain | RENOVIS, INC. | 2006-05-11 | — | — | US | disclosed |
| EP-1578717-A2 | NITRONE COMPOUNDS, PHARMACEUTICAL COMPOSITIONS CONTAINING THE SAME AND METHODS FOR TREATING INFLAMMATION AND NEUROPATHIC PAIN | Renovis, Inc. (US) | 2005-09-28 | — | — | EP | disclosed |
| US-20040142983-A1 | Nitrone compounds, pharmaceutical compositions containing the same and methods for treating inflammation and neuropathic pain | RENOVIS, INC. | 2004-07-22 | — | — | US | disclosed |
| WO-2004034999-A2 | NITRONE COMPOUNDS, PHARMACEUTICAL COMPOSITIONS CONTAINING THE SAME AND METHODS FOR TREATING INFLAMMATION AND NEUROPATHIC PAIN | RENOVIS, INC. (US) | 2004-04-29 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060100289-A1 | Nitrone compounds, pharmaceutical compositions containing the same and methods for treating inflammation and neuropathic pain | MMP8, PTGES, NGF | MAOB 1252/4885SLC6A2 1702/4885TAAR1 857/4885 |
| US-20040142983-A1 | Nitrone compounds, pharmaceutical compositions containing the same and methods for treating inflammation and neuropathic pain | MMP8, PTGES, NGF | MAOB 1252/4885SLC6A2 1702/4885TAAR1 857/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.