SCHEMBL5675658

SCHEMBL5675658

CCCCC(CC)C[Si](Cl)(CC(CC)CCCC)C(C)(C)C(C)C

nearest known ligand 0.39

Predicted protein targets (top 7)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 3/20 0.39
TDP1 Q9NUW8 2/20 0.39
CYP3A4 P08684 4/20 0.38
TSHR P16473 3/20 0.38
CA2 P00918 2/20 0.33
L3MBTL1 Q9Y468 1/20 0.33
ATM Q13315 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7568798 0.83 ALDH1A1 (0.43) ALDH1A1TDP1CYP3A4TSHRCA2
SCHEMBL5699062 0.80 ALDH1A1 (0.41) ALDH1A1TDP1CYP3A4TSHRCA2
SCHEMBL2686734 0.74 ALDH1A1 (0.50) ALDH1A1TDP1CYP3A4TSHRCA2
SCHEMBL132156 0.74 ALDH1A1 (0.50) ALDH1A1TDP1CYP3A4TSHRCA2
SCHEMBL22555588 0.72 ALDH1A1 (0.48) ALDH1A1TDP1CYP3A4TSHRCA2
SCHEMBL9703821 0.69 ALDH1A1 (0.54) ALDH1A1TDP1CYP3A4TSHRCA2
SCHEMBL10636470 0.68 ALDH1A1 (0.52) ALDH1A1TDP1CYP3A4TSHRCA2
SCHEMBL19091741 0.68 ALDH1A1 (0.52) ALDH1A1TDP1CYP3A4TSHRCA2
SCHEMBL2869579 0.67 LMNA (0.46) ALDH1A1TDP1CYP3A4TSHRL3MBTL1
SCHEMBL29001284 0.67 LMNA (0.46) ALDH1A1TDP1CYP3A4TSHRL3MBTL1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-6518447-B2 Reacting 2,3-dimethyl-2-butene with a hydrogenchlorosilane compound in presence of aluminum chloride to form thexylchlorosilanes SHIN-ETSU CHEMICAL CO., LTD. (JP) 2003-02-11 US claimed
EP-1238980-B1 Silyl (meth)acrylates having bulky substituent group and preparation thereof SHINETSU CHEMICAL CO (JP) 2006-06-14 EP disclosed
EP-1203772-B1 Thexylchlorosilanes, their manufacture and use SHINETSU CHEMICAL CO (JP) 2006-01-11 EP disclosed
US-6518447-B2 Reacting 2,3-dimethyl-2-butene with a hydrogenchlorosilane compound in presence of aluminum chloride to form thexylchlorosilanes SHIN-ETSU CHEMICAL CO., LTD. (JP) 2003-02-11 US disclosed
US-6498264-B2 REACTING A CHLOROSILANE COMPOUND WITH ACRYLIC OR METHACRYLIC ACID IN THE PRESENCE OF A BASIC COMPOUND; PROTECTIVE HYDROLYSABLE COATINGS FOR SHIP BOTTOMS; NONTOXIC; POLLUTION CONTROL; KINETICS SHIN-ETSU CHEMICAL CO., LTD. (JP) 2002-12-24 US disclosed
US-20020128503-A1 Silyl (meth)acrylates having bulky substituent group and preparation thereof SHIN-ETSU CHEMICAL CO., LTD. (JP) 2002-09-12 US disclosed
EP-1238980-A1 Silyl (meth)acrylates having bulky substituent group and preparation thereof SHIN-ETSU CHEMICAL CO., LTD. (JP) 2002-09-11 EP disclosed
US-20020055647-A1 Thexylchlorosilanes and making process SHIN-ETSU CHEMICAL CO., LTD. (JP) 2002-05-09 US disclosed
EP-1203772-A2 Thexylchlorosilanes, their manufacture and use Shin-Etsu Chemical Co., Ltd. (JP) 2002-05-08 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20020128503-A1 Silyl (meth)acrylates having bulky substituent group and preparation thereof SMS, MASTL, ACR ALDH1A1 791/4885TDP1 3651/4885CYP3A4 873/4885
US-20020055647-A1 Thexylchlorosilanes and making process LSS, SCLY, TET2 ALDH1A1 1900/4885TDP1 2919/4885CYP3A4 418/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.