SCHEMBL56864

SCHEMBL56864

O=C(O)Oc1ccccc1Cl

nearest known ligand 0.50

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
PTK2B Q14289 1/20 0.50
CXCL8 P10145 1/20 0.50
BCHE P06276 1/20 0.49
HPGD P15428 2/20 0.47
TP53 P04637 2/20 0.47
RXRA P19793 1/20 0.47
RXRB P28702 1/20 0.47
HTT P42858 1/20 0.47
ALDH1A1 P00352 1/20 0.46
MAPT P10636 1/20 0.46
MEN1 O00255 4/20 0.46
KMT2A Q03164 4/20 0.46
PKM P14618 1/20 0.46
LMNA P02545 2/20 0.46
TSHR P16473 1/20 0.46
SMN1; SMN2 Q16637 3/20 0.45
RAB9A P51151 2/20 0.45
NPC1 O15118 1/20 0.44
MITF O75030 1/20 0.44
XBP1 P17861 1/20 0.44

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Hydrochloric Acid SCHEMBL11843856 0.98 PTK2B (0.49) PTK2BCXCL8BCHEHPGDTP53
SCHEMBL2947498 0.84 PTK2B (0.51) PTK2BCXCL8BCHEHPGDTP53
SCHEMBL56863 0.84 PTK2B (0.51) PTK2BCXCL8BCHEHPGDTP53
SCHEMBL29450644 0.84 PTK2B (0.51) PTK2BCXCL8BCHEHPGDTP53
SCHEMBL1637925 0.84 AKR1C3 (0.47) PTK2BCXCL8BCHEHPGDTP53
SCHEMBL143632 0.83 KDM4E (0.46) HPGDTP53ALDH1A1MAPTKMT2A
SCHEMBL100191 0.83 TSHR (0.50) CXCL8TP53HTTALDH1A1MAPT
SCHEMBL695666 0.82 PTK2B (0.50) PTK2BCXCL8BCHEHPGDTP53
SCHEMBL3199958 0.82 PTK2B (0.50) PTK2BCXCL8BCHEHPGDTP53
SCHEMBL5706002 0.81 KMT2A (0.63) PTK2BHPGDTP53RXRARXRB

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 239 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-115677999-B Polycarbonate and preparation method and application thereof 华为技术有限公司 2024-05-14 CN claimed
CN-117645540-A Preparation method of chlorophenoxycarboxylate 山东润博生物科技有限公司 2024-03-05 CN claimed
CN-117466730-A Preparation method of phenoxy carboxylate herbicide 山东润博生物科技有限公司 2024-01-30 CN claimed
CN-116789542-A Preparation method and post-treatment method of chlorophenoxycarboxylic acid herbicide 山东润博生物科技有限公司 2023-09-22 CN claimed
CN-113968963-B Polycarbonate and preparation method and application thereof 万华化学集团股份有限公司 2023-08-11 CN claimed
CN-114085368-B Polycarbonate and preparation method and application thereof 万华化学集团股份有限公司 2023-08-11 CN claimed
CN-111111696-B Solvothermal method for synthesizing sulfide-TiO with regular morphology in one pot2Method for compounding nanostructures and use thereof 中南民族大学 2022-07-01 CN claimed
CN-114085368-A Polycarbonate and preparation method and application thereof 万华化学集团股份有限公司 2022-02-25 CN claimed
US-11078150-B2 Preparation method for chlorophenoxycarboxylate SHANDONG RAINBOW BIOTECH CO., LTD. (CN) 2021-08-03 US claimed
US-20210002201-A1 PREPARATION METHOD FOR CHLOROPHENOXYCARBOXYLATE SHANDONG RAINBOW BIOTECH CO., LTD. (CN) 2021-01-07 US claimed
WO-2004030617-A2 POLYMER CONJUGATES WITH DECREASED ANTIGENICITY, METHODS OF PREPARATION AND USES THEREOF MOUNTAIN VIEW PHARMACEUTICALS, INC. (US) 2004-04-15 WO claimed
US-20040062748-A1 Polymer conjugates with decreased antigenicity, methods of preparation and uses thereof MOUNTAIN VIEW PHARMACEUTICALS, INC. 2004-04-01 US claimed
US-20040062746-A1 Polymer conjugates with decreased antigenicity, methods of preparation and uses thereof MOUNTAIN VIEW PHARMACEUTICALS, INC. 2004-04-01 US claimed
US-20030012777-A1 Polymer conjugates of proteinases MOUNTAIN VIEW PHARMACEUTICALS, INC. 2003-01-16 US claimed
WO-2003002716-A2 POLYMER STABILIZED PROTEINASES MOUNTAIN VIEW PHARMACEUTICALS, INC. (US) 2003-01-09 WO claimed
US-20020016293-A1 Flavopiridol drug combinations and methods with reduced side effects NIH - DEITR 2002-02-07 US claimed
WO-2001080896-A2 FLAVOPIRIDOL DRUG COMBINATIONS AND METHODS WITH REDUCED SIDE EFFECTS ARCH DEVELOPMENT CORPORATION (US) 2001-11-01 WO claimed
US-5786344-A ADMINISTERING WITH AGENT WHICH INCREASES ACTIVITY OF GLUCURONOSYLTRANSFERASE OR DECREASES ACTIVITY OF BILIARY TRANSPORT PROTEIN ARCH DEVELOPMENT CORPORATION (US) 1998-07-28 US claimed
EP-0768895-A1 CAMPTOTHECIN DRUG COMBINATIONS AND MEDICAMENTS WITH REDUCED SIDE EFFECTS ARCH DEVELOPMENT CORPORATION (US) 1997-04-23 EP claimed
WO-1996001127-A1 CAMPTOTHECIN DRUG COMBINATIONS AND MEDICAMENTS WITH REDUCED SIDE EFFECTS ARCH DEVELOPMENT CORPORATION (US) 1996-01-18 WO claimed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (6 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20020016293-A1 Flavopiridol drug combinations and methods with reduced side effects UGT1A1, UGT1A3, CYP7A1 PTK2B 4535/4885CXCL8 3199/4885BCHE 295/4885
US-20210002201-A1 PREPARATION METHOD FOR CHLOROPHENOXYCARBOXYLATE CBLB, CBL, CBLC PTK2B 853/4885CXCL8 3994/4885BCHE 233/4885
US-20040062748-A1 Polymer conjugates with decreased antigenicity, methods of preparation and uses thereof CD14, HLA-C, HLA-A PTK2B 2151/4885CXCL8 943/4885BCHE 578/4885
US-20040062746-A1 Polymer conjugates with decreased antigenicity, methods of preparation and uses thereof CD14, HLA-C, HLA-A PTK2B 2151/4885CXCL8 943/4885BCHE 578/4885
US-11078150-B2 Preparation method for chlorophenoxycarboxylate CBLB, CBL, CBLC PTK2B 853/4885CXCL8 3994/4885BCHE 233/4885
US-20030012777-A1 Polymer conjugates of proteinases PRNP, PRSS3, PRSS1 PTK2B 4700/4885CXCL8 3361/4885BCHE 86/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.