SCHEMBL5687632

SCHEMBL5687632

Cc1cccc(Cc2ccc(OC(=O)N3CCC(Sc4nnnn4CCN(C)C)CC3)cc2)n1

nearest known ligand 0.36

Predicted protein targets (top 11)

geneUniProtsupporting neighboursconfidence
UBE2M P61081 13/20 0.36
DCUN1D1 Q96GG9 13/20 0.36
ALDH1A1 P00352 1/20 0.35
USP2 O75604 1/20 0.33
HTT P42858 1/20 0.33
KMT2A Q03164 1/20 0.33
SMO Q99835 1/20 0.33
KDM1A O60341 2/20 0.33
CYP1A2 P05177 1/20 0.33
CYP2C19 P33261 1/20 0.33
GAA P10253 1/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL5690721 0.93 UBE2M (0.35) UBE2MDCUN1D1ALDH1A1USP2HTT
SCHEMBL5688877 0.91 ALDH1A1 (0.35) ALDH1A1USP2HTTKMT2ASMO
SCHEMBL5689800 0.89 SMO (0.35) ALDH1A1USP2HTTKMT2ASMO
SCHEMBL5688311 0.89 CYP1A2 (0.41) ALDH1A1USP2KMT2ASMOCYP1A2
SCHEMBL5687424 0.88 GAA (0.35) UBE2MDCUN1D1ALDH1A1SMOGAA
SCHEMBL5688602 0.86 GRIN2B (0.34) UBE2MDCUN1D1SMOCYP1A2CYP2C19
SCHEMBL5688888 0.85 NOS3 (0.34) UBE2MDCUN1D1SMOKDM1A
SCHEMBL5690242 0.84 SMO (0.36) UBE2MDCUN1D1ALDH1A1KMT2ASMO
SCHEMBL5687373 0.84 FFAR1 (0.35) ALDH1A1USP2HTTKMT2ACYP1A2
SCHEMBL5687919 0.83 LIPE (0.41) UBE2MDCUN1D1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20060160851-A1 Substituted piperidine carbamates NOVO NORDISK A/S (DK) 2006-07-20 US claimed
EP-1636207-A1 SUBSTITUTED PIPERIDINE CARBAMATES FOR USE AS INHIBITORS OF HORMONE SENSITIVE LIPASE NOVO NORDISK A/S (DK) 2006-03-22 EP claimed
WO-2004111032-A1 SUBSTITUTED PIPERIDINE CARBAMATES FOR USE AS INHIBITORS OF HORMONE SENSITIVE LIPASE NOVO NORDISK A/S (DK) 2004-12-23 WO claimed
US-20060160851-A1 Substituted piperidine carbamates NOVO NORDISK A/S (DK) 2006-07-20 US disclosed
EP-1636207-A1 SUBSTITUTED PIPERIDINE CARBAMATES FOR USE AS INHIBITORS OF HORMONE SENSITIVE LIPASE NOVO NORDISK A/S (DK) 2006-03-22 EP disclosed
WO-2004111032-A1 SUBSTITUTED PIPERIDINE CARBAMATES FOR USE AS INHIBITORS OF HORMONE SENSITIVE LIPASE NOVO NORDISK A/S (DK) 2004-12-23 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20060160851-A1 Substituted piperidine carbamates LIPE, PNLIP, LIPC UBE2M 3021/4885DCUN1D1 4035/4885ALDH1A1 1044/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.