Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTT | P42858 | 1/20 | 0.38 |
| ▸ | HTR4 | Q13639 | 1/20 | 0.37 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.36 |
| ▸ | MAPT | P10636 | 2/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.36 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.36 |
| ▸ | PDE5A | O76074 | 1/20 | 0.36 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.36 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.36 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | MCHR1 | Q99705 | 3/20 | 0.36 |
| ▸ | QPCT | Q16769 | 1/20 | 0.35 |
| ▸ | FLT1 | P17948 | 1/20 | 0.35 |
| ▸ | KDR | P35968 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL569786 | 0.83 | HCAR2 (0.48) | ALDH1A1MAPTKDM4EHDAC8SMN1; SMN2 | |
| SCHEMBL569245 | 0.83 | KMT2A (0.41) | HTTALDH1A1MAPTKDM4EMAPK1 | |
| SCHEMBL569396 | 0.81 | ALDH1A1 (0.38) | HTTLRRK2ALDH1A1MAPTKDM4E | |
| SCHEMBL569928 | 0.81 | LRRK2 (0.38) | LRRK2MAPTKDM4EMAPK1PDE5A | |
| SCHEMBL10183272 | 0.78 | CFTR (0.41) | LRRK2ALDH1A1MAPTKDM4EPDE5A | |
| SCHEMBL569756 | 0.76 | DRD3 (0.54) | HTTALDH1A1MAPTKDM4ETDP1 | |
| SCHEMBL569408 | 0.75 | MAPT (0.42) | HTTALDH1A1MAPTKDM4ETDP1 | |
| SCHEMBL10182349 | 0.75 | CFTR (0.43) | LRRK2ALDH1A1MAPTKDM4ESMN1; SMN2 | |
| SCHEMBL10182336 | 0.74 | TP53 (0.58) | ALDH1A1MAPTKDM4ETDP1SMN1; SMN2 | |
| SCHEMBL10183415 | 0.73 | DRD2 (0.51) | ALDH1A1MAPTKDM4ESMN1; SMN2MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2601208-A2 | LIGANDS FOR ANTIBODY AND Fc-FUSION PROTEIN PURIFICATION BY AFFINITY CHROMATOGRAPHY | Graffinity Pharmaceuticals GmbH (DE) | 2013-06-12 | — | — | EP | disclosed |
| WO-2012017021-A2 | LIGANDS FOR ANTIBODY AND Fc-FUSION PROTEIN PURIFICATION BY AFFINITY CHROMATOGRAPHY | GRAFFINITY PHARMACEUTICALS GMBH (DE) | 2012-02-09 | — | — | WO | disclosed |