SCHEMBL5694205

SCHEMBL5694205

O=S(=O)(Oc1nccn1-c1ccccc1)C(F)(F)F

nearest known ligand 0.40

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
L3MBTL1 Q9Y468 5/20 0.40
ALOX15B O15296 3/20 0.40
FDPS P14324 1/20 0.38
ESR2 Q92731 1/20 0.37
CYP1A2 P05177 5/20 0.36
CYP3A4 P08684 5/20 0.36
CYP2D6 P10635 5/20 0.36
CYP2C9 P11712 5/20 0.36
CYP2C19 P33261 5/20 0.36
SMN1; SMN2 Q16637 3/20 0.36
RAB9A P51151 2/20 0.36
NPC1 O15118 1/20 0.36
NR3C2 P08235 3/20 0.35
ALDH1A1 P00352 4/20 0.35
MITF O75030 1/20 0.35
LMNA P02545 1/20 0.35
HTT P42858 1/20 0.35
MEN1 O00255 2/20 0.34
KMT2A Q03164 2/20 0.34
PDE4A P27815 1/20 0.34

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL5694139 0.83 NR4A1 (0.41) ESR2CYP3A4SMN1; SMN2RAB9ANPC1
SCHEMBL317712 0.74 CHRNB2 (0.36) FDPSMEN1KMT2A
SCHEMBL1681801 0.72 FPR2 (0.33) SMN1; SMN2ALDH1A1KMT2APOLB
SCHEMBL5175571 0.72 CYP3A4 (0.43) L3MBTL1ALOX15BFDPSCYP1A2CYP3A4
SCHEMBL1681893 0.71 LMNA (0.37) CYP3A4CYP2C9CYP2C19SMN1; SMN2LMNA
SCHEMBL4296439 0.71 SMN1; SMN2 (0.47) SMN1; SMN2
SCHEMBL23956239 0.70 NR3C2 (0.34) ESR2NR3C2F2F10PRSS1
SCHEMBL8721211 0.69 CYP3A4 (0.41) L3MBTL1ALOX15BFDPSCYP1A2CYP3A4
SCHEMBL3967152 0.68 L3MBTL1 (0.50) L3MBTL1ALOX15BFDPSCYP1A2CYP3A4
SCHEMBL20721904 0.68 CYP2C9 (0.40) L3MBTL1CYP2C9RAB9ANPC1ALDH1A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 19 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-111039977-B Phosphorylylation reagent and application thereof in oligonucleotide synthesis 广州同隽医药科技有限公司 2022-11-08 CN claimed
CN-111039977-A Phosphorylylation reagent and application thereof in oligonucleotide synthesis 广州同隽医药科技有限公司 2020-04-21 CN claimed
CN-111039977-B Phosphorylylation reagent and application thereof in oligonucleotide synthesis 广州同隽医药科技有限公司 2022-11-08 CN disclosed
EP-2873674-B1 CHIRAL NUCLEIC ACID ADJUVANT SHIN NIPPON BIOMEDICAL LABORATORIES LTD (JP) 2020-05-06 EP disclosed
CN-111039977-A Phosphorylylation reagent and application thereof in oligonucleotide synthesis 广州同隽医药科技有限公司 2020-04-21 CN disclosed
US-10322173-B2 Chiral nucleic acid adjuvant having anti-allergic activity, and anti-allergic agent SHIN NIPPON BIOMEDICAL LABORATORIES, LTD. (JP) 2019-06-18 US disclosed
US-10149905-B2 Chiral nucleic acid adjuvant having antitumor effect and antitumor agent SHIN NIPPON BIOMEDICAL LABORATORIES, LTD. (JP) 2018-12-11 US disclosed
US-10144933-B2 Chiral nucleic acid adjuvant having immunity induction activity, and immunity induction activator SHIN NIPPON BIOMEDICAL LABORATORIES, LTD. (JP) 2018-12-04 US disclosed
US-9617547-B2 Chiral nucleic acid adjuvant SHIN NIPPON BIOMEDICAL LABORATORIES, LTD. (JP) 2017-04-11 US disclosed
EP-3095459-A1 CHIRAL NUCLEIC ACID ADJUVANT HAVING ANTITUMOR EFFECT AND ANTITUMOR AGENT Shin Nippon Biomedical Laboratories, Ltd. (JP) 2016-11-23 EP disclosed
EP-3095460-A1 CHIRAL NUCLEIC ACID ADJUVANT HAVING ANTI-ALLERGIC ACTIVITY, AND ANTI-ALLERGIC AGENT Shin Nippon Biomedical Laboratories, Ltd. (JP) 2016-11-23 EP disclosed
EP-3095461-A1 CHIRAL NUCLEIC ACID ADJUVANT HAVING IMMUNITY INDUCTION ACTIVITY, AND IMMUNITY INDUCTION ACTIVATOR Shin Nippon Biomedical Laboratories, Ltd. (JP) 2016-11-23 EP disclosed
US-20160333349-A1 CHIRAL NUCLEIC ACID ADJUVANT HAVING IMMUNITY INDUCTION ACTIVITY, AND IMMUNITY INDUCTION ACTIVATOR WAVE LIFE SCIENCES JAPAN, INC. (JP) 2016-11-17 US disclosed
US-20160331835-A1 CHIRAL NUCLEIC ACID ADJUVANT HAVING ANTI-ALLERGIC ACTIVITY, AND ANTI-ALLERGIC AGENT WAVE LIFE SCIENCES JAPAN, INC. (JP) 2016-11-17 US disclosed
US-20160331836-A1 CHIRAL NUCLEIC ACID ADJUVANT HAVING ANTITUMOR EFFECT AND ANTITUMOR AGENT WAVE LIFE SCIENCES JAPAN, INC. (JP) 2016-11-17 US disclosed
US-20150166999-A1 CHIRAL NUCLEIC ACID ADJUVANT SHIN NIPPON BIOMEDICAL LABORATORIES, LTD. (JP) 2015-06-18 US disclosed
EP-2873674-A1 CHIRAL NUCLEIC ACID ADJUVANT Shin Nippon Biomedical Laboratories, Ltd. (JP) 2015-05-20 EP disclosed
US-20060167241-A1 Method for synthesizing cyclic bisdinucleoside MITSUI CHEMICALS, INC. (JP) 2006-07-27 US disclosed
EP-1645561-A1 METHOD OF SYNTHESIZING CYCLIC BISDINUCLEOSIDE Mitsui Chemicals, Inc. (JP) 2006-04-12 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (7 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20150166999-A1 CHIRAL NUCLEIC ACID ADJUVANT IFNAR1, IFNG, IRF3 L3MBTL1 2188/4885ALOX15B 1089/4885FDPS 3799/4885
US-20160331836-A1 CHIRAL NUCLEIC ACID ADJUVANT HAVING ANTITUMOR EFFECT AND ANTITUMOR AGENT DDX21, DDX24, TLR9 L3MBTL1 1417/4885ALOX15B 1638/4885FDPS 3820/4885
US-10149905-B2 Chiral nucleic acid adjuvant having antitumor effect and antitumor agent DDX21, DDX24, TLR9 L3MBTL1 1417/4885ALOX15B 1638/4885FDPS 3820/4885
US-10322173-B2 Chiral nucleic acid adjuvant having anti-allergic activity, and anti-allergic agent TLR9, POLL, MRGPRX2 L3MBTL1 1392/4885ALOX15B 542/4885FDPS 4433/4885
US-20060167241-A1 Method for synthesizing cyclic bisdinucleoside NSUN2, POLR2H, POLB L3MBTL1 398/4885ALOX15B 3345/4885FDPS 1281/4885
US-10144933-B2 Chiral nucleic acid adjuvant having immunity induction activity, and immunity induction activator TLR9, IRF3, TLR3 L3MBTL1 467/4885ALOX15B 1517/4885FDPS 2283/4885
US-20160331835-A1 CHIRAL NUCLEIC ACID ADJUVANT HAVING ANTI-ALLERGIC ACTIVITY, AND ANTI-ALLERGIC AGENT TLR9, MRGPRX2, POLL L3MBTL1 1982/4885ALOX15B 504/4885FDPS 4277/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.