Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Sulfadiazine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 3/20 | 0.96 |
| ▸ | AURKA | O14965 | 1/20 | 0.96 |
| ▸ | DHFR | P00374 | 1/20 | 0.96 |
| ▸ | TSHR | P16473 | 1/20 | 0.96 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.66 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.65 |
| ▸ | MAPT | P10636 | 2/20 | 0.65 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.59 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.57 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.57 |
| ▸ | MEN1 | O00255 | 1/20 | 0.57 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.57 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.56 |
| ▸ | PRMT1 | Q99873 | 1/20 | 0.56 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.55 |
| ▸ | EDNRA | P25101 | 1/20 | 0.55 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.55 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.55 |
| ▸ | PRMT6 | Q96LA8 | 1/20 | 0.55 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Sulfadiazine SCHEMBL18668477 | 0.98 | LMNA (0.93) | LMNAAURKADHFRTSHRSMN1; SMN2 | |
| Sulfadiazine SCHEMBL10422849 | 0.98 | LMNA (1.00) | LMNAAURKADHFRTSHRSMN1; SMN2 | |
| Sulfadiazine SCHEMBL24176 | 0.98 | LMNA (1.00) | LMNAAURKADHFRTSHRSMN1; SMN2 | |
| Sulfadiazine SCHEMBL30080807 | 0.98 | LMNA (1.00) | LMNAAURKADHFRTSHRSMN1; SMN2 | |
| Sulfadiazine SCHEMBL34517 | 0.96 | LMNA (0.96) | LMNAAURKADHFRTSHRSMN1; SMN2 | |
| Sulfadiazine SCHEMBL5870705 | 0.96 | LMNA (0.96) | LMNAAURKADHFRTSHRSMN1; SMN2 | |
| Sulfadiazine SCHEMBL6141086 | 0.96 | LMNA (0.96) | LMNAAURKADHFRTSHRSMN1; SMN2 | |
| Sulfadiazine SCHEMBL11611850 | 0.96 | LMNA (0.96) | LMNAAURKADHFRTSHRSMN1; SMN2 | |
| Sulfadiazine SCHEMBL5870853 | 0.96 | LMNA (0.96) | LMNAAURKADHFRTSHRSMN1; SMN2 | |
| Sulfadiazine SCHEMBL3728176 | 0.96 | LMNA (0.96) | LMNAAURKADHFRTSHRSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 308 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-122005895-A | Biological dressing and preparation method and application thereof | 天津市托福医用原子能科技有限公司 | 2026-05-12 | — | — | CN | claimed |
| CN-119269423-A | Method for determining lead salt in sulfadiazine zinc raw material | 河南省药品医疗器械检验院(河南省疫苗批签中心) | 2025-01-07 | — | — | CN | claimed |
| CN-118697691-A | Skin injury treatment ointment and preparation method thereof | 邵明冰 | 2024-09-27 | — | — | CN | claimed |
| CN-114533655-A | Improved sulfadiazine zinc-silver cream and preparation method thereof | 中国人民武装警察部队特色医学中心 | 2022-05-27 | — | — | CN | claimed |
| CN-114103295-A | Regenerated environment-friendly antibacterial fabric cloth and preparation method thereof | 安徽亿盈特纤新材料有限公司 | 2022-03-01 | — | — | CN | claimed |
| CN-113293512-A | Antibacterial skin-friendly non-woven fabric and preparation method thereof | 冠和卫生用品有限公司 | 2021-08-24 | — | — | CN | claimed |
| CN-113279144-A | Environment-friendly degradable non-woven fabric and preparation method thereof | 冠和卫生用品有限公司 | 2021-08-20 | — | — | CN | claimed |
| US-20210094954-A1 | PREPARATION METHODS AND APPLICATIONS OF 3,5-DISUBSTITUTED METHYLPYRAZOLO[1,5-A]PYRIMIDINE-7-HYDROXYLIC SALTS | XU LIFENG (US) | 2021-04-01 | — | — | US | claimed |
| CN-112007006-A | A pharmaceutical composition for treating oral ulcer, and its preparation method | 山东省药学科学院 | 2020-12-01 | — | — | CN | claimed |
| CN-109224015-A | A kind of rheumatic arthritis ointment | 湖北科田药业有限公司 | 2019-01-18 | — | — | CN | claimed |
| CN-1660442-A | Transmission system for medicine containing trehalose and hyaluronic acid in use for curing burn and preparing method | UNIV CHINA OCEAN (CN) | 2005-08-31 | — | — | CN | claimed |
| CN-1312078-A | Making process of compound sulfadiazine zinc spreader | CHENGDU CITY INST OF MEDICINE (CN) | 2001-09-12 | — | — | CN | claimed |
| CN-1299293-A | Adhesive applicator with polymerization agent and/or bioactive material | CLOSURE MEDICAL CORP (US) | 2001-06-13 | — | — | CN | claimed |
| EP-1073484-A1 | ADHESIVE APPLICATOR WITH POLYMERIZATION AGENTS AND/OR BIOACTIVE MATERIAL | Closure Medical Corporation (US) | 2001-02-07 | — | — | EP | claimed |
| WO-1999055394-A1 | ADHESIVE APPLICATOR WITH POLYMERIZATION AGENTS AND/OR BIOACTIVE MATERIAL | CLOSURE MEDICAL CORPORATION (US) | 1999-11-04 | — | — | WO | claimed |
| EP-0480189-A1 | Pharmaceutical compositions for topical use comprising hyaluronic acid sodium salt and disinfectant substances | ALTERGON S.A. (CH) | 1992-04-15 | — | — | EP | claimed |
| US-4579731-A | POLYVINYL ALCOHOL, POLYVINYLPYROLIDONE, AND GLYCEROL | KEY PHARMACEUTICALS, INC. (US) | 1986-04-01 | — | — | US | claimed |
| US-4559223-A | ANTICARIES AGENTS, ANTIPLAQUE AGENTS, GINGIVAL INHIBITORS | DALTEX MEDICAL SCIENCES, INC. (US) | 1985-12-17 | — | — | US | claimed |
| US-4078058-A | Cerium sulfadiazine for treating burns | RESEARCH CORPORATION (US) | 1978-03-07 | — | — | US | claimed |
| US-4049802-A | Zinc sulfadiazine and its use in the treatment of burns | RESEARCH CORPORATION (US) | 1977-09-20 | — | — | US | claimed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20210094954-A1 | PREPARATION METHODS AND APPLICATIONS OF 3,5-DISUBSTITUTED METHYLPYRAZOLO[1,5-A]PYRIMIDINE-7-HYDROXYLIC SALTS | DHPS, NUDT1, DPYD | LMNA 4063/4885AURKA 578/4885DHFR 28/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.