Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD11B1 | P28845 | 1/20 | 0.46 |
| ▸ | GPR119 | Q8TDV5 | 2/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.43 |
| ▸ | NPC1 | O15118 | 2/20 | 0.43 |
| ▸ | RAB9A | P51151 | 2/20 | 0.43 |
| ▸ | HTT | P42858 | 1/20 | 0.43 |
| ▸ | CCR5 | P51681 | 2/20 | 0.42 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.41 |
| ▸ | YAP1 | P46937 | 3/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 2/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.41 |
| ▸ | JAK2 | O60674 | 1/20 | 0.40 |
| ▸ | JAK1 | P23458 | 1/20 | 0.40 |
| ▸ | STS | P08842 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18163678 | 0.90 | HSD11B1 (0.50) | HSD11B1GPR119SMN1; SMN2NPC1RAB9A | |
| SCHEMBL18154352 | 0.87 | HSD11B1 (0.48) | HSD11B1GPR119SMN1; SMN2NPC1RAB9A | |
| SCHEMBL18163683 | 0.86 | HSD11B1 (0.48) | HSD11B1GPR119SMN1; SMN2NPC1RAB9A | |
| SCHEMBL16094709 | 0.86 | HTT (0.49) | GPR119SMN1; SMN2NPC1RAB9AHTT | |
| SCHEMBL5725684 | 0.84 | OPRM1 (0.51) | HSD11B1CCR5 | |
| SCHEMBL18163696 | 0.84 | CCR5 (0.47) | HSD11B1CCR5L3MBTL1 | |
| SCHEMBL16095616 | 0.82 | GPR119 (0.48) | GPR119SMN1; SMN2NPC1RAB9AHTT | |
| SCHEMBL6687688 | 0.82 | L3MBTL1 (0.43) | HSD11B1CCR5L3MBTL1KMT2A | |
| SCHEMBL8893633 | 0.81 | L3MBTL1 (0.45) | HSD11B1CCR5L3MBTL1 | |
| SCHEMBL18154142 | 0.81 | CCR5 (0.46) | HSD11B1CCR5L3MBTL1JAK2JAK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1719770-A2 | Quinoline derivatives as antibacterials | SMITHKLINE BEECHAM PLC (GB) | 2006-11-08 | — | — | EP | disclosed |
| EP-1320529-B1 | QUINOLINE DERIVATIVES AS ANTIBACTERIALS | SMITHKLINE BEECHAM PLC (GB) | 2006-05-24 | — | — | EP | disclosed |
| US-20040053928-A1 | Quinoline derivatives as antibacterials | SMITHKLINE BEECHAM P.L.C. (GB) | 2004-03-18 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040053928-A1 | Quinoline derivatives as antibacterials | AAAS, QDPR, QARS1 | HSD11B1 4840/4885GPR119 2884/4885SMN1; SMN2 3620/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.