Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNMA1 | Q12791 | 8/20 | 0.56 |
| ▸ | GAA | P10253 | 5/20 | 0.53 |
| ▸ | RAB9A | P51151 | 2/20 | 0.51 |
| ▸ | LMNA | P02545 | 1/20 | 0.51 |
| ▸ | TSHR | P16473 | 1/20 | 0.51 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.51 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.46 |
| ▸ | NPC1 | O15118 | 2/20 | 0.46 |
| ▸ | TP53 | P04637 | 1/20 | 0.46 |
| ▸ | MAPT | P10636 | 2/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.44 |
| ▸ | HTT | P42858 | 2/20 | 0.44 |
| ▸ | POLB | P06746 | 1/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.44 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.43 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.43 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.43 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.43 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5728705 | 0.83 | KCNMA1 (0.56) | KCNMA1GAARAB9ALMNATSHR | |
| SCHEMBL24460251 | 0.78 | LMNA (0.52) | KCNMA1GAARAB9ALMNATSHR | |
| SCHEMBL14363390 | 0.73 | KCNMA1 (0.66) | KCNMA1GAARAB9ALMNATSHR | |
| SCHEMBL4928655 | 0.72 | KCNMA1 (0.70) | KCNMA1GAARAB9ALMNATSHR | |
| SCHEMBL4923998 | 0.71 | KCNMA1 (0.60) | KCNMA1GAARAB9ALMNATSHR | |
| SCHEMBL2605540 | 0.70 | KCNMA1 (0.82) | KCNMA1GAARAB9ATSHRSMN1; SMN2 | |
| SCHEMBL30742732 | 0.70 | MAPT (0.42) | LMNATSHRHSD17B10MAPTKMT2A | |
| SCHEMBL5685695 | 0.70 | MAPT (0.42) | LMNATSHRHSD17B10MAPTKMT2A | |
| SCHEMBL5135887 | 0.70 | G6PD (0.56) | LMNA | |
| SCHEMBL5727470 | 0.70 | ALDH1A1 (0.51) | LMNAALDH1A1CYP1A2CYP3A4CYP2D6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1633715-A1 | 2-(6-AMINO-PYRIDIN-3-YL)-2-HYDROXYETHYLAMINE DERIVATIVES AS BETA 2-ADRENOCEPTORS AGONISTS | Pfizer Limited (GB) | 2006-03-15 | — | — | EP | claimed |
| WO-2004108676-A1 | 2-(6-AMINO-PYRIDIN-3-YL)-2-HYDROXYETHYLAMINE DERIVATIVES AS BETA 2-ADRENOCEPTORS AGONISTS | PFIZER LIMITED (GB) | 2004-12-16 | — | — | WO | claimed |