Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNMA1 | Q12791 | 7/20 | 0.56 |
| ▸ | GAA | P10253 | 8/20 | 0.53 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.48 |
| ▸ | RAB9A | P51151 | 3/20 | 0.48 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.48 |
| ▸ | TSHR | P16473 | 2/20 | 0.48 |
| ▸ | LMNA | P02545 | 1/20 | 0.48 |
| ▸ | NPC1 | O15118 | 4/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.46 |
| ▸ | TP53 | P04637 | 2/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.44 |
| ▸ | MAPT | P10636 | 3/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.44 |
| ▸ | POLB | P06746 | 1/20 | 0.44 |
| ▸ | HTT | P42858 | 1/20 | 0.44 |
| ▸ | MEN1 | O00255 | 4/20 | 0.43 |
| ▸ | CASP3 | P42574 | 2/20 | 0.42 |
| ▸ | SENP7 | Q9BQF6 | 2/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5728699 | 0.83 | KCNMA1 (0.56) | KCNMA1GAAHDAC1RAB9AHSD17B10 | |
| SCHEMBL14363390 | 0.73 | KCNMA1 (0.66) | KCNMA1GAARAB9AHSD17B10TSHR | |
| SCHEMBL4928655 | 0.72 | KCNMA1 (0.70) | KCNMA1GAARAB9AHSD17B10TSHR | |
| SCHEMBL4923998 | 0.71 | KCNMA1 (0.60) | KCNMA1GAARAB9AHSD17B10TSHR | |
| SCHEMBL2605540 | 0.70 | KCNMA1 (0.82) | KCNMA1GAARAB9ATSHRNPC1 | |
| SCHEMBL24460251 | 0.70 | LMNA (0.52) | KCNMA1GAARAB9AHSD17B10TSHR | |
| SCHEMBL5135888 | 0.70 | MMP2 (0.52) | GAARAB9AHSD17B10NPC1MAPT | |
| SCHEMBL5685703 | 0.70 | ALDH1A1 (0.42) | GAAHSD17B10TSHRLMNAKMT2A | |
| SCHEMBL27778033 | 0.70 | PLK1 (0.46) | GAARAB9AHSD17B10TSHRNPC1 | |
| SCHEMBL1964014 | 0.70 | RAB9A (0.71) | KCNMA1RAB9AHSD17B10TSHRLMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1633715-A1 | 2-(6-AMINO-PYRIDIN-3-YL)-2-HYDROXYETHYLAMINE DERIVATIVES AS BETA 2-ADRENOCEPTORS AGONISTS | Pfizer Limited (GB) | 2006-03-15 | — | — | EP | claimed |
| WO-2004108676-A1 | 2-(6-AMINO-PYRIDIN-3-YL)-2-HYDROXYETHYLAMINE DERIVATIVES AS BETA 2-ADRENOCEPTORS AGONISTS | PFIZER LIMITED (GB) | 2004-12-16 | — | — | WO | claimed |