SCHEMBL573404

SCHEMBL573404

O=S(=O)(O)n1c(-c2ccccc2)nc2ccccc21

nearest known ligand 0.53

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
KDM4E B2RXH2 4/20 0.53
HSD17B10 Q99714 4/20 0.53
ESR1 P03372 1/20 0.49
ESR2 Q92731 1/20 0.49
ALDH3A1 P30838 4/20 0.47
ALDH1A1 P00352 3/20 0.47
HPGD P15428 3/20 0.47
PDE6D O43924 1/20 0.47
ALDH2 P05091 1/20 0.47
LMNA P02545 2/20 0.47
TSHR P16473 1/20 0.47
SMN1; SMN2 Q16637 1/20 0.46
CXCL8 P10145 1/20 0.46
NOD1 Q9Y239 1/20 0.46
CA1 P00915 1/20 0.46
CA2 P00918 1/20 0.46
MEN1 O00255 1/20 0.44
NPC1 O15118 1/20 0.44
RAB9A P51151 1/20 0.44
KMT2A Q03164 1/20 0.44

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL24696307 0.83 KDM4E (0.49) KDM4EHSD17B10ESR1ESR2ALDH3A1
SCHEMBL7048551 0.82 KDM4E (0.37) KDM4EHSD17B10ESR1ESR2ALDH3A1
SCHEMBL11607699 0.82 NOD1 (0.65) KDM4EHSD17B10ALDH3A1ALDH1A1HPGD
SCHEMBL28309320 0.81 KDM4E (0.50) KDM4EHSD17B10ALDH3A1ALDH1A1HPGD
SCHEMBL28309197 0.77 ALDH3A1 (0.72) HSD17B10ALDH3A1ALDH1A1HPGDLMNA
SCHEMBL28063595 0.76 SMN1; SMN2 (0.52) KDM4EHSD17B10ALDH3A1ALDH1A1HPGD
SCHEMBL990493 0.76 NOD1 (0.45) KDM4EHSD17B10ALDH3A1ALDH1A1HPGD
SCHEMBL9394279 0.75 NOD1 (0.42) KDM4EHSD17B10ALDH3A1ALDH1A1HPGD
SCHEMBL11327144 0.75 NOD1 (0.44) KDM4EHSD17B10ALDH3A1ALDH1A1HPGD
SCHEMBL9320052 0.75 NOD1 (0.44) KDM4EHSD17B10ALDH3A1ALDH1A1HPGD

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 217 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-113164792-A Liquid transparent mixtures of UV filters 西姆莱斯股份公司 2021-07-23 CN claimed
CN-106132386-B Topical compositions 帝斯曼知识产权资产管理有限公司 2020-06-02 CN claimed
EP-3125856-B1 TOPICAL COMPOSITIONS DSM IP ASSETS BV (NL) 2019-07-03 EP claimed
EP-3052072-B1 TOPICAL SUN SCREEN COMPOSITIONS COMPRISING TITANIUM DIOXIDE AND SILICA DSM IP ASSETS BV (NL) 2018-04-18 EP claimed
EP-3019142-B1 UV SCREENING COMPOSITION COMPRISING A UV FILTER, AN ORGANOPOLYSILOXANE FUNCTIONALIZED WITH A UV ABSORBER AND POROUS SILICA AND / OR POLYMETHYLMETHACRYLATE PARTICLES DSM IP ASSETS BV (NL) 2017-10-04 EP claimed
US-20170087069-A1 TOPICAL COMPOSITIONS DSM IP ASSETS B.V. (NL) 2017-03-30 US claimed
EP-3125856-A1 TOPICAL COMPOSITIONS DSM IP Assets B.V. (NL) 2017-02-08 EP claimed
US-20160206527-A1 TOPICAL SUN SCREEN COMPOSITIONS TITANIUM DIOXIDE AND SILICA DSM IP ASSETS B.V. (NL) 2016-07-21 US claimed
US-20160143831-A1 UV SCREENING COMPOSITION COMPRISING A UV FILTER, AN ORGANOPOLYSILOXANE FUNCTIONALIZED WITH A UV ABSORBER AND POROUS SILICA AND/OR POLYMETHYLMETHACRYLATE PARTICLES DSM IP ASSETS B.V. (NL) 2016-05-26 US claimed
EP-3019142-A1 UV SCREENING COMPOSITION COMPRISING A UV FILTER, AN ORGANOPOLYSILOXANE FUNCTIONALIZED WITH A UV ABSORBER AND POROUS SILICA AND/OR POLYMETHYLMETHACRYLATE PARTICLES DSM IP Assets B.V. (NL) 2016-05-18 EP claimed
EP-0838214-B1 Cosmetic compositions containing a combination of UV-absorbers including a triazine derivative BASF AG (DE) 2005-01-05 EP claimed
EP-1167358-B1 2-Phenylbenzimidazole sulphonic acids as UV-B filters MERCK PATENT GMBH (DE) 2004-09-15 EP claimed
EP-1341752-B1 NOVEL INDANYLIDENE COMPOUNDS SYMRISE GMBH & CO KG (DE) 2004-08-04 EP claimed
US-20020143203-A1 Novel indanylidene compounds SYMRISE GMBH & CO. KG (DE) 2002-10-03 US claimed
US-6440401-B1 2-PHENYLBENZIMIDAZOLEDI- AND TRISULFONIC ACIDS; COSMETIC FORMULATIONS MERCK PATENT GESELLSCHAFT MIT BESCHRAENKTER HAFTUNG (DE) 2002-08-27 US claimed
US-20020055532-A1 UV-B filter MERCK PATENT GESELLSCHAFT (DE) 2002-05-09 US claimed
US-20020016349-A1 UV-B filters MERCK PATENT GESELLSCHAFT (DE) 2002-02-07 US claimed
US-6153174-A Cosmetic compositions comprising a combination of UV absorbers BASF AKTIENGESELLSCHAFT (DE) 2000-11-28 US claimed
US-6123929-A A COSMETIC SUNSCREEN COMPRISES IN AN AQUEOUS PHASE A 2-PHENYLBENZIMIDAZOLE SULFONIC ACID OR SALT AND A FATTY PHASE CONTAINING A LINEAR OR CYCLIC MODIFIED POLYSILOXANE ROCHE VITAMINS INC. (US) 2000-09-26 US claimed
EP-0979645-A1 Light screening composition containing a polysiloxane type UV-B screening agent and a benzimidazol type UV-B screening agent F. HOFFMANN-LA ROCHE AG (CH) 2000-02-16 EP claimed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (6 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20020055532-A1 UV-B filter CBR1, UQCRB, H1-0 KDM4E 2453/4885HSD17B10 1899/4885ESR1 2386/4885
US-20160143831-A1 UV SCREENING COMPOSITION COMPRISING A UV FILTER, AN ORGANOPOLYSILOXANE FUNCTIONALIZED WITH A UV ABSORBER AND POROUS SILICA AND/OR POLYMETHYLMETHACRYLATE PARTICLES RAD50, SERPINB10, XRCC5 KDM4E 2032/4885HSD17B10 2389/4885ESR1 2824/4885
US-20020143203-A1 Novel indanylidene compounds CUTA, NISCH, ERCC4 KDM4E 1177/4885HSD17B10 512/4885ESR1 3804/4885
US-20020016349-A1 UV-B filters CBR1, H1-0, CYP1B1 KDM4E 2421/4885HSD17B10 1936/4885ESR1 2329/4885
US-20160206527-A1 TOPICAL SUN SCREEN COMPOSITIONS TITANIUM DIOXIDE AND SILICA RAD50, DSG1, SLC30A7 KDM4E 1778/4885HSD17B10 1636/4885ESR1 1985/4885
US-20170087069-A1 TOPICAL COMPOSITIONS DSG1, RAD50, PLIN5 KDM4E 3634/4885HSD17B10 710/4885ESR1 4861/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.