Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIGMAR1 | Q99720 | 3/20 | 0.40 |
| ▸ | HTR1A | P08908 | 1/20 | 0.37 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.37 |
| ▸ | PARP1 | P09874 | 3/20 | 0.36 |
| ▸ | KDR | P35968 | 2/20 | 0.35 |
| ▸ | PDE5A | O76074 | 1/20 | 0.35 |
| ▸ | TP53 | P04637 | 1/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 2/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | ENPP2 | Q13822 | 1/20 | 0.35 |
| ▸ | TLR9 | Q9NR96 | 2/20 | 0.35 |
| ▸ | TLR8 | Q9NR97 | 2/20 | 0.35 |
| ▸ | TLR7 | Q9NYK1 | 2/20 | 0.35 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.34 |
| ▸ | SRC | P12931 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5740914 | 0.94 | ALDH1A1 (0.42) | KDRPDE5AMAPK1ALDH1A1TLR9 | |
| SCHEMBL5739782 | 0.90 | MAPT (0.36) | KDRTP53ALDH1A1MAPT | |
| SCHEMBL1461097 | 0.89 | SIGMAR1 (0.39) | SIGMAR1PARP1KDRTP53MAPK1 | |
| SCHEMBL5739297 | 0.86 | MAPT (0.34) | KDRTP53ALDH1A1MAPTPDGFRB | |
| SCHEMBL5740106 | 0.84 | SYK (0.37) | KDRTP53MEN1KMT2AALDH1A1 | |
| SCHEMBL1460905 | 0.82 | MAPK14 (0.44) | KDRPDE5AMAPK1ALDH1A1 | |
| SCHEMBL5740762 | 0.82 | KMT2A (0.32) | KDRTP53MEN1KMT2AALDH1A1 | |
| SCHEMBL5738334 | 0.82 | KDM4E (0.43) | TP53ALDH1A1MAPT | |
| SCHEMBL5739596 | 0.79 | MET (0.39) | KDRPDGFRB | |
| SCHEMBL5740995 | 0.79 | MET (0.33) | KDR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1183033-B1 | PYRROLOTRIAZINE INHIBITORS OF KINASES | BRISTOL MYERS SQUIBB CO (US) | 2006-03-01 | — | — | EP | claimed |