Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.37 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.35 |
| ▸ | DUT | P33316 | 1/20 | 0.34 |
| ▸ | SLC6A2 | P23975 | 3/20 | 0.34 |
| ▸ | SLC6A4 | P31645 | 3/20 | 0.34 |
| ▸ | SLC6A3 | Q01959 | 3/20 | 0.34 |
| ▸ | HPGD | P15428 | 1/20 | 0.33 |
| ▸ | ELOVL1 | Q9BW60 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.33 |
| ▸ | RAB9A | P51151 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | HCAR2 | Q8TDS4 | 1/20 | 0.32 |
| ▸ | LMNA | P02545 | 1/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19438939 | 0.84 | SLC6A3 (0.43) | TAAR1SLC6A2SLC6A4SLC6A3 | |
| SCHEMBL1245973 | 0.83 | ELOVL1 (0.41) | TAAR1DUTELOVL1 | |
| SCHEMBL4148913 | 0.82 | CHRM2 (0.47) | L3MBTL1KMT2AALDH1A1KDM4ELMNA | |
| SCHEMBL5696917 | 0.76 | ALDH1A1 (0.35) | TAAR1HPGDKMT2AALDH1A1RAB9A | |
| SCHEMBL503098 | 0.74 | TAAR1 (0.33) | TAAR1ELOVL1HCAR2 | |
| SCHEMBL574575 | 0.74 | ADRB2 (0.35) | ELOVL1KMT2A | |
| SCHEMBL503485 | 0.74 | TAAR1 (0.33) | TAAR1ELOVL1HCAR2 | |
| SCHEMBL574831 | 0.74 | ADRB2 (0.35) | ELOVL1KMT2A | |
| SCHEMBL574882 | 0.72 | TAAR1 (0.41) | TAAR1SLC6A2SLC6A4SLC6A3ELOVL1 | |
| SCHEMBL2142867 | 0.71 | DUT (0.38) | DUT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2600853-A1 | COMBINATIONS COMPRISING ATYPICAL ANTIPSYCHOTICS AND TAAR1 AGONISTS | F.HOFFMANN-LA ROCHE AG (CH) | 2013-06-12 | — | — | EP | disclosed |
| WO-2012016879-A1 | COMBINATIONS COMPRISING ATYPICAL ANTIPSYCHOTICS AND TAAR1 AGONISTS | F. HOFFMANN-LA ROCHE AG (CH) | 2012-02-09 | — | — | WO | disclosed |