Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TAAR1 | Q96RJ0 | 3/20 | 0.41 |
| ▸ | AOC3 | Q16853 | 1/20 | 0.40 |
| ▸ | ELOVL1 | Q9BW60 | 2/20 | 0.39 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.34 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.34 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.34 |
| ▸ | AQP1 | P29972 | 1/20 | 0.34 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1245973 | 0.84 | ELOVL1 (0.41) | TAAR1AOC3ELOVL1SIGMAR1 | |
| SCHEMBL9701242 | 0.72 | HRH3 (0.42) | TAAR1 | |
| SCHEMBL574561 | 0.72 | TAAR1 (0.37) | TAAR1ELOVL1SLC6A2SLC6A4SLC6A3 | |
| SCHEMBL19438939 | 0.71 | SLC6A3 (0.43) | TAAR1SLC6A2SLC6A4SLC6A3SIGMAR1 | |
| SCHEMBL1121430 | 0.71 | IDO1 (0.50) | — | |
| SCHEMBL2027168 | 0.70 | LOXL2 (0.41) | — | |
| SCHEMBL2696466 | 0.70 | CYP1A2 (0.41) | TAAR1 | |
| SCHEMBL503098 | 0.69 | TAAR1 (0.33) | TAAR1AOC3ELOVL1 | |
| SCHEMBL503485 | 0.69 | TAAR1 (0.33) | TAAR1AOC3ELOVL1 | |
| SCHEMBL574575 | 0.69 | ADRB2 (0.35) | ELOVL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2600853-A1 | COMBINATIONS COMPRISING ATYPICAL ANTIPSYCHOTICS AND TAAR1 AGONISTS | F.HOFFMANN-LA ROCHE AG (CH) | 2013-06-12 | — | — | EP | disclosed |
| WO-2012016879-A1 | COMBINATIONS COMPRISING ATYPICAL ANTIPSYCHOTICS AND TAAR1 AGONISTS | F. HOFFMANN-LA ROCHE AG (CH) | 2012-02-09 | — | — | WO | disclosed |