Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD11B1 | P28845 | 1/20 | 0.44 |
| ▸ | TACR3 | P29371 | 1/20 | 0.42 |
| ▸ | FEN1 | P39748 | 1/20 | 0.42 |
| ▸ | SPR | P35270 | 2/20 | 0.42 |
| ▸ | MEN1 | O00255 | 2/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.41 |
| ▸ | MAPT | P10636 | 2/20 | 0.40 |
| ▸ | SCD5 | Q86SK9 | 1/20 | 0.40 |
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
| ▸ | BLM | P54132 | 1/20 | 0.40 |
| ▸ | TP53 | P04637 | 1/20 | 0.39 |
| ▸ | COMT | P21964 | 1/20 | 0.39 |
| ▸ | RIPK1 | Q13546 | 1/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
| ▸ | HCRTR1 | O43613 | 1/20 | 0.39 |
| ▸ | HCRTR2 | O43614 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5749644 | 0.81 | SCD5 (0.48) | FEN1SPRALDH1A1SMN1; SMN2MAPT | |
| SCHEMBL6989102 | 0.77 | HSD11B1 (0.50) | HSD11B1TACR3SPRMEN1KMT2A | |
| SCHEMBL6989185 | 0.74 | TACR3 (0.48) | HSD11B1TACR3SPRMEN1KMT2A | |
| SCHEMBL31324479 | 0.72 | TACR3 (0.62) | HSD11B1TACR3SPRMEN1KMT2A | |
| SCHEMBL14263092 | 0.70 | TACR3 (0.59) | HSD11B1TACR3MEN1KMT2AALDH1A1 | |
| SCHEMBL22048483 | 0.70 | TACR3 (0.59) | HSD11B1TACR3SPRMEN1KMT2A | |
| SCHEMBL21138804 | 0.70 | HSD11B1 (0.62) | HSD11B1TACR3SPRMEN1KMT2A | |
| SCHEMBL6986268 | 0.69 | HCRTR1 (0.47) | HSD11B1KDM4ERIPK1HCRTR1HCRTR2 | |
| SCHEMBL6266160 | 0.68 | CYP2C9 (0.61) | TACR3SPRMEN1KMT2AALDH1A1 | |
| SCHEMBL14395951 | 0.68 | FAAH (0.51) | HSD11B1TACR3SPRALDH1A1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1326610-B1 | AZA-AND POLYAZA-NAPHTHALENYL CARBOXAMIDES USEFUL AS HIV INTEGRASE INHIBITORS | MERCK & CO INC (US) | 2006-11-15 | — | — | EP | claimed |
| US-6841558-B2 | Aza-and polyaza-naphthalenyl carboxamides useful as HIV intergrase inhibitors | MERCK & CO., INC. (US) | 2005-01-11 | — | — | US | claimed |
| EP-1326610-A4 | AZA-AND POLYAZA-NAPHTHALENYL CARBOXAMIDES USEFUL AS HIV INTEGRASE INHIBITORS | MERCK & CO INC (US) | 2004-06-09 | — | — | EP | claimed |
| US-20040044207-A1 | Aza-and polyaza-naphthalenyl carboxamides useful as HIV integrase inhibitors | MERCK & CO., INC. | 2004-03-04 | — | — | US | claimed |
| EP-1326610-A2 | AZA-AND POLYAZA-NAPHTHALENYL CARBOXAMIDES USEFUL AS HIV INTEGRASE INHIBITORS | Merck & Co., Inc. (US) | 2003-07-16 | — | — | EP | claimed |
| WO-2002055079-A2 | AZA-AND POLYAZA-NAPHTHALENYL CARBOXAMIDES USEFUL AS HIV INTEGRASE INHIBITORS | MERCK & CO INC (US) | 2002-07-18 | — | — | WO | claimed |
| EP-1326610-B1 | AZA-AND POLYAZA-NAPHTHALENYL CARBOXAMIDES USEFUL AS HIV INTEGRASE INHIBITORS | MERCK & CO INC (US) | 2006-11-15 | — | — | EP | disclosed |
| US-6841558-B2 | Aza-and polyaza-naphthalenyl carboxamides useful as HIV intergrase inhibitors | MERCK & CO., INC. (US) | 2005-01-11 | — | — | US | disclosed |
| US-20040044207-A1 | Aza-and polyaza-naphthalenyl carboxamides useful as HIV integrase inhibitors | MERCK & CO., INC. | 2004-03-04 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040044207-A1 | Aza-and polyaza-naphthalenyl carboxamides useful as HIV integrase inhibitors | POLI, DUT, NAAA | HSD11B1 3216/4885TACR3 3150/4885FEN1 481/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.