Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SCD5 | Q86SK9 | 4/20 | 0.48 |
| ▸ | RAB9A | P51151 | 5/20 | 0.47 |
| ▸ | NPC1 | O15118 | 4/20 | 0.47 |
| ▸ | ATM | Q13315 | 1/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.46 |
| ▸ | MAPT | P10636 | 2/20 | 0.46 |
| ▸ | FEN1 | P39748 | 1/20 | 0.46 |
| ▸ | SPR | P35270 | 2/20 | 0.45 |
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.45 |
| ▸ | SCD | O00767 | 2/20 | 0.44 |
| ▸ | TP53 | P04637 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.44 |
| ▸ | POLB | P06746 | 1/20 | 0.44 |
| ▸ | PROKR1 | Q8TCW9 | 2/20 | 0.43 |
| ▸ | HPGD | P15428 | 1/20 | 0.42 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.42 |
| ▸ | APLNR | P35414 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2143922 | 0.83 | ALDH1A1 (0.52) | SCD5RAB9ANPC1ATMSMN1; SMN2 | |
| SCHEMBL5747403 | 0.81 | HSD11B1 (0.44) | SCD5NPC1SMN1; SMN2MAPTFEN1 | |
| SCHEMBL2143792 | 0.76 | ALDH1A1 (0.54) | SCD5SPRSCDALDH1A1 | |
| SCHEMBL20820350 | 0.74 | PROKR1 (0.53) | SCD5MAPTKDM4CTP53ALDH1A1 | |
| SCHEMBL16735634 | 0.74 | KDM4C (0.54) | SCD5RAB9ANPC1ATMSMN1; SMN2 | |
| SCHEMBL31304869 | 0.71 | FEN1 (0.60) | MAPTFEN1KDM4CALDH1A1 | |
| SCHEMBL968338 | 0.71 | FEN1 (0.60) | MAPTFEN1KDM4CALDH1A1 | |
| SCHEMBL22639994 | 0.71 | SCD5 (0.60) | SCD5RAB9ANPC1ATMSMN1; SMN2 | |
| SCHEMBL22640181 | 0.71 | SCD5 (0.60) | SCD5RAB9ANPC1ATMSMN1; SMN2 | |
| SCHEMBL12447335 | 0.71 | RAB9A (0.72) | SCD5RAB9ANPC1ATMSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 29 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1326610-B1 | AZA-AND POLYAZA-NAPHTHALENYL CARBOXAMIDES USEFUL AS HIV INTEGRASE INHIBITORS | MERCK & CO INC (US) | 2006-11-15 | — | — | EP | claimed |
| US-6841558-B2 | Aza-and polyaza-naphthalenyl carboxamides useful as HIV intergrase inhibitors | MERCK & CO., INC. (US) | 2005-01-11 | — | — | US | claimed |
| US-20040044207-A1 | Aza-and polyaza-naphthalenyl carboxamides useful as HIV integrase inhibitors | MERCK & CO., INC. | 2004-03-04 | — | — | US | claimed |
| US-20230190730-A1 | 4-OXOQUINOLINE COMPOUND AND USE THEREOF AS PHARMACEUTICAL AGENT | JAPAN TOBACCO INC. (JP) | 2023-06-22 | — | — | US | disclosed |
| US-20230190730-A1 | 4-OXOQUINOLINE COMPOUND AND USE THEREOF AS PHARMACEUTICAL AGENT | JAPAN TOBACCO INC. (JP) | 2023-06-22 | — | — | US | disclosed |
| US-20150174117-A1 | 4-OXOQUINOLINE COMPOUND AND USE THEREOF AS PHARMACEUTICAL AGENT | JAPAN TOBACCO INC. | 2015-06-25 | — | — | US | disclosed |
| US-20150174117-A1 | 4-OXOQUINOLINE COMPOUND AND USE THEREOF AS PHARMACEUTICAL AGENT | JAPAN TOBACCO INC. | 2015-06-25 | — | — | US | disclosed |
| US-20140364389-A1 | Combination Therapy | JAPAN TOBACCO INC. (JP) | 2014-12-11 | — | — | US | disclosed |
| US-20140364389-A1 | Combination Therapy | JAPAN TOBACCO INC. (JP) | 2014-12-11 | — | — | US | disclosed |
| US-8633219-B2 | Combination therapy | JAPAN TOBACCO INC. (JP) | 2014-01-21 | — | — | US | disclosed |
| US-8633219-B2 | Combination therapy | JAPAN TOBACCO INC. (JP) | 2014-01-21 | — | — | US | disclosed |
| US-7211572-B2 | Nitrogen-containing fused ring compound and use thereof as HIV integrase inhibitor | JAPAN TOBACCO INC. (JP) | 2007-05-01 | — | — | US | disclosed |
| US-7176220-B2 | 4-oxoquinoline compound and use thereof as pharmaceutical agent | JAPAN TOBACCO INC. (JP) | 2007-02-13 | — | — | US | disclosed |
| US-7176220-B2 | 4-oxoquinoline compound and use thereof as pharmaceutical agent | JAPAN TOBACCO INC. (JP) | 2007-02-13 | — | — | US | disclosed |
| EP-1326610-B1 | AZA-AND POLYAZA-NAPHTHALENYL CARBOXAMIDES USEFUL AS HIV INTEGRASE INHIBITORS | MERCK & CO INC (US) | 2006-11-15 | — | — | EP | disclosed |
| US-6841558-B2 | Aza-and polyaza-naphthalenyl carboxamides useful as HIV intergrase inhibitors | MERCK & CO., INC. (US) | 2005-01-11 | — | — | US | disclosed |
| EP-1326610-A4 | AZA-AND POLYAZA-NAPHTHALENYL CARBOXAMIDES USEFUL AS HIV INTEGRASE INHIBITORS | MERCK & CO INC (US) | 2004-06-09 | — | — | EP | disclosed |
| US-20040044207-A1 | Aza-and polyaza-naphthalenyl carboxamides useful as HIV integrase inhibitors | MERCK & CO., INC. | 2004-03-04 | — | — | US | disclosed |
| EP-1326610-A2 | AZA-AND POLYAZA-NAPHTHALENYL CARBOXAMIDES USEFUL AS HIV INTEGRASE INHIBITORS | Merck & Co., Inc. (US) | 2003-07-16 | — | — | EP | disclosed |
| WO-2002055079-A2 | AZA-AND POLYAZA-NAPHTHALENYL CARBOXAMIDES USEFUL AS HIV INTEGRASE INHIBITORS | MERCK & CO INC (US) | 2002-07-18 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20150174117-A1 | 4-OXOQUINOLINE COMPOUND AND USE THEREOF AS PHARMACEUTICAL AGENT | IMPDH1, CDKL4, IMPDH2 | SCD5 1860/4885RAB9A 3060/4885NPC1 726/4885 |
| US-20230190730-A1 | 4-OXOQUINOLINE COMPOUND AND USE THEREOF AS PHARMACEUTICAL AGENT | IMPDH1, IMPDH2, DNTT | SCD5 1714/4885RAB9A 2870/4885NPC1 792/4885 |
| US-20140364389-A1 | Combination Therapy | TYMP, TPMT, PNP | SCD5 1744/4885RAB9A 4503/4885NPC1 474/4885 |
| US-20040044207-A1 | Aza-and polyaza-naphthalenyl carboxamides useful as HIV integrase inhibitors | POLI, DUT, NAAA | SCD5 1720/4885RAB9A 3045/4885NPC1 532/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.