SCHEMBL574741

SCHEMBL574741

COC[C@H]1O[C@@H](n2cnc3c(=S)[nH]c(N)nc32)[C@H](O)[C@@H]1O

nearest known ligand 0.65

Predicted protein targets (top 12)

geneUniProtsupporting neighboursconfidence
▸ ADORA3 P0DMS8 5/20 0.65
▸ HINT1 P49773 5/20 0.58
▸ NT5E P21589 1/20 0.56
▸ GSK3A P49840 2/20 0.53
▸ RPS6KA3 P51812 2/20 0.53
▸ MAPK14 Q16539 2/20 0.53
▸ ADORA2A P29274 1/20 0.53
▸ ADORA2B P29275 1/20 0.53
▸ TGM2 P21980 1/20 0.52
▸ IMPDH2 P12268 1/20 0.51
▸ IMPDH1 P20839 1/20 0.51
▸ PNP P00491 1/20 0.51

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL26294891 0.88 HINT1 (0.56) ADORA3HINT1NT5EADORA2AADORA2B
SCHEMBL5360770 0.88 HINT1 (0.56) ADORA3HINT1NT5EADORA2AADORA2B
2'-Beta-Methyl-Guanosine SCHEMBL383785 0.88 HINT1 (0.75) ADORA3HINT1NT5EGSK3ARPS6KA3
2'-Beta-Methyl-Guanosine SCHEMBL116165 0.88 HINT1 (0.75) ADORA3HINT1NT5EGSK3ARPS6KA3
2'-Beta-Methyl-Guanosine SCHEMBL14178410 0.88 HINT1 (0.75) ADORA3HINT1NT5EGSK3ARPS6KA3
2'-Beta-Methyl-Guanosine SCHEMBL11965261 0.88 HINT1 (0.75) ADORA3HINT1NT5EGSK3ARPS6KA3
2'-Beta-Methyl-Guanosine SCHEMBL15338533 0.88 HINT1 (0.75) ADORA3HINT1NT5EGSK3ARPS6KA3
Thioguanosine SCHEMBL1981035 0.87 LMNA (0.62) ADORA3NT5EADORA2AADORA2B
Thioguanosine SCHEMBL4527562 0.87 LMNA (0.62) ADORA3NT5EADORA2AADORA2B
Thioguanosine SCHEMBL230740 0.87 LMNA (0.62) ADORA3NT5EADORA2AADORA2B

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 599 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-4705481-A2 CIRCULAR RNA COMPOSITIONS AND METHODS Orna Therapeutics, Inc. (US) 2026-03-11 — — EP claimed
WO-2025151711-A1 NUCLEIC ACID VACCINES TARGETING METHANOGENS Arkea Bio Corp. (US) 2025-07-17 — — WO claimed
EP-4554616-A1 COMPOSITIONS AND METHODS FOR REDUCING METHANE EMISSIONS IN RUMINANT POPULATIONS Arkea Bio Corp. (US) 2025-05-21 — — EP claimed
WO-2024233308-A2 CIRCULAR RNA COMPOSITIONS AND METHODS ORNA THERAPEUTICS, INC. (US) 2024-11-14 — — WO claimed
WO-2024012270-A1 COMPOSITION FOR ORGAN-SPECIFIC DELIVERY OF NUCLEIC ACID 传信生物医药(苏州)有限公司 2024-01-18 — — WO claimed
WO-2024015366-A1 COMPOSITIONS AND METHODS FOR REDUCING METHANE EMISSIONS IN RUMINANT POPULATIONS Arkea Bio Corp. (US) 2024-01-18 — — WO claimed
US-20240009291-A1 COMPOSITIONS AND METHODS FOR REDUCING METHANE EMISSIONS IN RUMINANT POPULATIONS Arkea Bio Corp. 2024-01-11 — — US claimed
WO-2023178182-A1 COMPOSITIONS AND METHODS FOR DETECTION AND TREATMENT OF CORONAVIRUS INFECTION 10X GENOMICS, INC. (US) 2023-09-21 — — WO claimed
US-11090332-B2 Antigen specific mRNA cellular cancer vaccines Regen BioPharma, Inc. (US) 2021-08-17 — — US claimed
EP-3423595-A1 RNA ANALYSIS BY TOTAL HYDROLYSIS CureVac AG (DE) 2019-01-09 — — EP claimed
EP-2833894-A1 MODIFIED POLYNUCLEOTIDES FOR THE PRODUCTION OF COSMETIC PROTEINS AND PEPTIDES Moderna Therapeutics, Inc. (US) 2015-02-11 — — EP claimed
EP-2755693-A2 ENGINEERED NUCLEIC ACIDS AND METHODS OF USE THEREOF Moderna Therapeutics, Inc. (US) 2014-07-23 — — EP claimed
EP-2710136-A1 ENGINEERED NUCLEIC ACIDS AND METHODS OF USE THEREOF FOR NON-HUMAN VERTEBRATES Moderna Therapeutics, Inc. (US) 2014-03-26 — — EP claimed
EP-2691101-A2 DELIVERY AND FORMULATION OF ENGINEERED NUCLEIC ACIDS Moderna Therapeutics, Inc. (US) 2014-02-05 — — EP claimed
WO-2013151671-A1 MODIFIED POLYNUCLEOTIDES FOR THE PRODUCTION OF COSMETIC PROTEINS AND PEPTIDES modeRNA Therapeutics (US) 2013-10-10 — — WO claimed
WO-2013151672-A2 MODIFIED POLYNUCLEOTIDES FOR THE PRODUCTION OF ONCOLOGY-RELATED PROTEINS AND PEPTIDES modeRNA Therapeutics (US) 2013-10-10 — — WO claimed
WO-2013151736-A2 IN VIVO PRODUCTION OF PROTEINS modeRNA Therapeutics (US) 2013-10-10 — — WO claimed
WO-2013039861-A2 ENGINEERED NUCLEIC ACIDS AND METHODS OF USE THEREOF modeRNA Therapeutics (US) 2013-03-21 — — WO claimed
WO-2012158736-A1 ENGINEERED NUCLEIC ACIDS AND METHODS OF USE THEREOF FOR NON-HUMAN VERTEBRATES modeRNA Therapeutics (US) 2012-11-22 — — WO claimed
WO-2012135805-A2 DELIVERY AND FORMULATION OF ENGINEERED NUCLEIC ACIDS modeRNA Therapeutics (US) 2012-10-04 — — WO claimed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20240009291-A1 COMPOSITIONS AND METHODS FOR REDUCING METHANE EMISSIONS IN RUMINANT POPULATIONS MT-CO2, CYB5R3, COX5A ADORA3 1579/4885HINT1 1972/4885NT5E 547/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.

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