Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADRA2A | P08913 | 3/20 | 0.54 |
| ▸ | ADRA2B | P18089 | 3/20 | 0.54 |
| ▸ | ADRA2C | P18825 | 3/20 | 0.54 |
| ▸ | SLC22A2 | O15244 | 1/20 | 0.47 |
| ▸ | NOS1 | P29475 | 10/20 | 0.44 |
| ▸ | NOS3 | P29474 | 8/20 | 0.44 |
| ▸ | NOS2 | P35228 | 8/20 | 0.44 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.43 |
| ▸ | TSHR | P16473 | 2/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.43 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.43 |
| ▸ | PLAU | P00749 | 1/20 | 0.41 |
| ▸ | ESR1 | P03372 | 1/20 | 0.37 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.37 |
| ▸ | NPY5R | Q15761 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5935352 | 0.86 | ADRA2A (0.44) | ADRA2AADRA2BADRA2CSLC22A2NOS1 | |
| SCHEMBL27981476 | 0.83 | NOS1 (0.62) | ADRA2AADRA2BADRA2CNOS1NOS3 | |
| SCHEMBL10533424 | 0.77 | HTR3E (0.54) | ADRA2AADRA2BADRA2CSLC22A2NOS1 | |
| SCHEMBL19063477 | 0.76 | NOS1 (0.56) | ADRA2AADRA2BADRA2CSLC22A2NOS1 | |
| SCHEMBL27981468 | 0.76 | HTR3E (0.52) | ADRA2AADRA2BADRA2CSLC22A2NOS1 | |
| SCHEMBL27981470 | 0.76 | NOS1 (0.56) | ADRA2AADRA2BADRA2CSLC22A2NOS1 | |
| SCHEMBL16079475 | 0.75 | ADRA2A (0.60) | ADRA2AADRA2BADRA2CSLC22A2NOS1 | |
| SCHEMBL664694 | 0.75 | NOS1 (0.52) | SLC22A2NOS1NOS3NOS2TSHR | |
| SCHEMBL14373123 | 0.72 | NOS3 (0.59) | NOS1NOS3NOS2TSHRALDH1A1 | |
| SCHEMBL48868 | 0.71 | PLG (0.52) | ADRA2AADRA2BADRA2CNOS1NOS3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20060269498-A1 | Hair shaping composition comprising at least one polyguanidine other than hydroxide | L'OREAL S.A. (FR) | 2006-11-30 | — | — | US | claimed |
| EP-1723947-A1 | Hair waving composition comprising at least a multiguanidine | L'OREAL (FR) | 2006-11-22 | — | — | EP | claimed |
| EP-1723946-A1 | Composition for straightening the hair comprising at least one multi-guanidine not being a hydroxide | L'OREAL (FR) | 2006-11-22 | — | — | EP | disclosed |
| EP-1723947-A1 | Hair waving composition comprising at least a multiguanidine | L'OREAL (FR) | 2006-11-22 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060269498-A1 | Hair shaping composition comprising at least one polyguanidine other than hydroxide | KRT18, PLOD3, PRKDC | ADRA2A 4865/4885ADRA2B 4840/4885ADRA2C 4859/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.