Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC1 | Q13547 | 2/20 | 0.47 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.47 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 6/20 | 0.46 |
| ▸ | LMNA | P02545 | 3/20 | 0.46 |
| ▸ | GAA | P10253 | 2/20 | 0.46 |
| ▸ | THRB | P10828 | 2/20 | 0.46 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.45 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.45 |
| ▸ | PKM | P14618 | 1/20 | 0.45 |
| ▸ | LTA4H | P09960 | 3/20 | 0.44 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.43 |
| ▸ | MEN1 | O00255 | 2/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.42 |
| ▸ | MAPT | P10636 | 2/20 | 0.42 |
| ▸ | USP2 | O75604 | 1/20 | 0.42 |
| ▸ | POLB | P06746 | 1/20 | 0.42 |
| ▸ | NR4A1 | P22736 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5885150 | 0.89 | SMN1; SMN2 (0.42) | HDAC1HDAC4KCNH2SMN1; SMN2LMNA | |
| SCHEMBL7421122 | 0.85 | SIGMAR1 (0.55) | HDAC1HDAC4KCNH2SMN1; SMN2LMNA | |
| SCHEMBL5672916 | 0.82 | HDAC1 (0.52) | HDAC1HDAC4KCNH2SMN1; SMN2LMNA | |
| SCHEMBL5885167 | 0.80 | LMNA (0.39) | HDAC1HDAC4KCNH2SMN1; SMN2LMNA | |
| SCHEMBL5885158 | 0.80 | LMNA (0.41) | HDAC1HDAC4KCNH2SMN1; SMN2LMNA | |
| SCHEMBL22014090 | 0.80 | HDAC1 (0.50) | HDAC1HDAC4KCNH2SMN1; SMN2LMNA | |
| SCHEMBL10074441 | 0.80 | HDAC1 (0.62) | HDAC1HDAC4KCNH2SMN1; SMN2LMNA | |
| SCHEMBL3013154 | 0.78 | ALDH1A1 (0.61) | HDAC1HDAC4KCNH2SMN1; SMN2LMNA | |
| SCHEMBL5885170 | 0.78 | LMNA (0.38) | HDAC1HDAC4KCNH2SMN1; SMN2LMNA | |
| Hydrochloric Acid SCHEMBL28833528 | 0.77 | ALDH1A1 (0.59) | HDAC1HDAC4KCNH2SMN1; SMN2LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 23 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7132427-B2 | Quinazolines and uses thereof | ARIAD PHARMACEUTICALS, INC. (US) | 2006-11-07 | — | — | US | disclosed |
| US-7019139-B2 | Quinolinones and uses thereof | ARIAD PHARMACEUTICALS, INC. (US) | 2006-03-28 | — | — | US | disclosed |
| EP-1408985-A4 | NOVEL PYRIDOPYRIMIDONES AND USES THEREOF | ARIAD PHARMA INC (US) | 2006-03-22 | — | — | EP | disclosed |
| US-7009054-B2 | Quinolines and uses thereof | ARIAD PHARMACEUTICALS, INC. (US) | 2006-03-07 | — | — | US | disclosed |
| US-6960572-B2 | Indolinones and uses thereof | ARIAD PHARMACEUTICALS, INC. (US) | 2005-11-01 | — | — | US | disclosed |
| EP-1408978-A4 | NOVEL PHENYLAMINO-PYRIMIDINES AND USES THEREOF | ARIAD PHARMA INC (US) | 2005-07-13 | — | — | EP | disclosed |
| US-6878697-B2 | Phenylamino-pyrimidines and uses thereof | ARIAD PHARMACEUTICALS, INC. (US) | 2005-04-12 | — | — | US | disclosed |
| US-20040242611-A1 | NOVEL PHENYLAMINO-PYRIMIDINES AND USES THEREOF | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2004-12-02 | — | — | US | disclosed |
| US-20040167101-A1 | Novel quinolinones and uses thereof | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2004-08-26 | — | — | US | disclosed |
| US-20040152671-A1 | Novel quinolines and uses thereof | ARIAD PHARMACEUTICALS, INC. | 2004-08-05 | — | — | US | disclosed |
| US-6706699-B2 | FOR THERAPY OF CANCER, OSTEOPOROSIS AND OTHER DISEASES INVOLVING UNTOWARD BONE RESORPTION E.G., PAGET'S DISEASE, PRIMARY AND SECONDARY HYPERPARATHYROIDISM, HUMORAL HYPERCALCEMIA OF MALIGNANCY | ARIAD PHARMACEUTICALS, INC. | 2004-03-16 | — | — | US | disclosed |
| US-20030130234-A1 | Novel indolinones and uses thereof | ARIAD PHARMACEUTICALS, INC. | 2003-07-10 | — | — | US | disclosed |
| US-20030114486-A1 | Novel quinolinones and uses thereof | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2003-06-19 | — | — | US | disclosed |
| US-20030114467-A1 | Novel pyrazolo- and pyrrolo-pyrimidines and uses thereof | ARIAD PHARMACEUTICALS, INC. | 2003-06-19 | — | — | US | disclosed |
| US-20030105115-A1 | Novel pyridopyrimidines and uses thereof | ARIAD PHARMACEUTICALS, INC. | 2003-06-05 | — | — | US | disclosed |
| US-20030105065-A1 | Novel quinolines and uses thereof | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2003-06-05 | — | — | US | disclosed |
| US-20030100572-A1 | Novel pyridopyrimidones and uses thereof | ARIAD PHARMACEUTICALS,INC. | 2003-05-29 | — | — | US | disclosed |
| US-20030100573-A1 | Novel quinazolines and uses thereof | ARIAD PHARMACEUTICALS, INC. | 2003-05-29 | — | — | US | disclosed |
| WO-2003000186-A2 | NOVEL PHENYLAMINO-PYRIMIDINES AND USES THEREOF | ARIAD PHARMACEUTICALS, INC. (US) | 2003-01-03 | — | — | WO | disclosed |
| WO-2003000270-A1 | NOVEL PYRIDOPYRIMIDONES AND USES THEREOF | ARIAD PHARMACEUTICALS, INC. (US) | 2003-01-03 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (10 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20030105065-A1 | Novel quinolines and uses thereof | UQCRB, RECQL, QTRT2 | HDAC1 2478/4885HDAC4 3380/4885KCNH2 352/4885 |
| US-20040242611-A1 | NOVEL PHENYLAMINO-PYRIMIDINES AND USES THEREOF | DPYD, TYMP, DDX41 | HDAC1 3806/4885HDAC4 4261/4885KCNH2 2345/4885 |
| US-20030100572-A1 | Novel pyridopyrimidones and uses thereof | UQCRB, RRM2B, CYP2B6 | HDAC1 3565/4885HDAC4 4193/4885KCNH2 313/4885 |
| US-20030105115-A1 | Novel pyridopyrimidines and uses thereof | DPYD, RRM2B, RRM2 | HDAC1 3844/4885HDAC4 4146/4885KCNH2 294/4885 |
| US-20030100573-A1 | Novel quinazolines and uses thereof | UQCRB, NQO2, RAB7A | HDAC1 2259/4885HDAC4 3360/4885KCNH2 676/4885 |
| US-20030114467-A1 | Novel pyrazolo- and pyrrolo-pyrimidines and uses thereof | TYMP, TYMS, DPYD | HDAC1 3686/4885HDAC4 4610/4885KCNH2 2130/4885 |
| US-20030114486-A1 | Novel quinolinones and uses thereof | UGT2B7, RAB7A, UQCRB | HDAC1 3041/4885HDAC4 3334/4885KCNH2 534/4885 |
| US-20040152671-A1 | Novel quinolines and uses thereof | UQCRB, RECQL, QTRT2 | HDAC1 2478/4885HDAC4 3380/4885KCNH2 352/4885 |
| US-20030130234-A1 | Novel indolinones and uses thereof | RDX, UQCRB, DRD1 | HDAC1 3131/4885HDAC4 3395/4885KCNH2 596/4885 |
| US-20040167101-A1 | Novel quinolinones and uses thereof | UGT2B7, RAB7A, UQCRB | HDAC1 3041/4885HDAC4 3334/4885KCNH2 534/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.