Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ERAP1 | Q9NZ08 | 5/20 | 0.43 |
| ▸ | CTSL | P07711 | 3/20 | 0.42 |
| ▸ | CTSB | P07858 | 2/20 | 0.42 |
| ▸ | CTSS | P25774 | 2/20 | 0.42 |
| ▸ | FABP4 | P15090 | 5/20 | 0.41 |
| ▸ | FABP5 | Q01469 | 5/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | CXCR5 | P32302 | 1/20 | 0.39 |
| ▸ | CXCR2 | P25025 | 1/20 | 0.38 |
| ▸ | TACR2 | P21452 | 1/20 | 0.37 |
| ▸ | FAAH | O00519 | 1/20 | 0.37 |
| ▸ | PYGL | P06737 | 1/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3554717 | 0.75 | GYS1 (0.52) | ALDH1A1 | |
| SCHEMBL1813782 | 0.74 | CTSL (0.64) | ERAP1CTSLCTSBCTSSFABP4 | |
| SCHEMBL5105697 | 0.71 | SMN1; SMN2 (0.51) | ALDH1A1POLB | |
| SCHEMBL1840233 | 0.68 | RAB9A (0.55) | ERAP1ALDH1A1TACR2POLB | |
| SCHEMBL1843420 | 0.67 | KDM4E (0.52) | ALDH1A1 | |
| SCHEMBL5418414 | 0.67 | FABP4 (0.61) | FABP4FABP5ALDH1A1POLB | |
| SCHEMBL1836676 | 0.67 | CTSK (0.61) | CTSLCTSBCTSSALDH1A1FAAH | |
| SCHEMBL13164041 | 0.66 | PYGL (0.54) | CXCR5PYGLPOLB | |
| SCHEMBL5756330 | 0.66 | ALDH1A1 (0.42) | ALDH1A1POLB | |
| SCHEMBL12831361 | 0.64 | CTSL (0.66) | CTSLCTSBCTSSTACR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1663936-A1 | BIARYLOXYMETHYLARENE-CARBOXYLIC ACIDS | F. HOFFMANN-LA ROCHE AG (CH) | 2006-06-07 | — | — | EP | disclosed |
| WO-2005000781-A1 | BIARYLOXYMETHYLARENE-CARBOXYLIC ACIDS | F. HOFFMANN-LA ROCHE AG (CH) | 2005-01-06 | — | — | WO | disclosed |